ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

(2018) Eytan M. Stein et al.   BLOOD

CDK9 inhibitors in acute myeloid leukemia

(2018) Silvia Boffo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML

(2018) Daniel Gerlach et al.   ONCOGENE

CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo

(2017) Jana Reimer et al.   HAEMATOLOGICA

Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia

(2017) Hiroshi Okuda et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

(2017) Jianbiao Zhou et al.   Journal of Hematology & Oncology

YEATS Domain—A Histone Acylation Reader in Health and Disease

(2017) Dan Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY

X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery

(2017) Jianbiao Zhou et al.   Molecular Oncology

Cancer epigenetics: Reading the future of leukaemia

(2017) Alex W. Wilkinson et al.   NATURE

Transcription control by the ENL YEATS domain in acute leukaemia

(2017) Michael A. Erb et al.   NATURE

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

(2017) Liling Wan et al.   NATURE

MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment

(2017) A Ugale et al.   ONCOGENE

CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo

(2017) Jana Reimer et al.   HAEMATOLOGICA

MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches

(2017) Amanda C. Winters et al.   Frontiers in Pediatrics

Emerging strategies for the treatment of older patients with acute myeloid leukemia

(2016) Miguel A. Sanz et al.   ANNALS OF HEMATOLOGY

Overview of CDK9 as a target in cancer research

(2016) Fatima Morales et al.   CELL CYCLE

The role of DOT1L in the maintenance of leukemia gene expression

(2016) Xi Wang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The roles of Polycomb group proteins in hematopoietic stem cells and hematological malignancies

(2016) Emi Takamatsu-Ichihara et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)

(2016) Q-Y Sun et al.   LEUKEMIA

LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell–like Transcriptional Program in AML

(2016) Jianbiao Zhou et al.   MOLECULAR CANCER RESEARCH

Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy

(2016) Caroline Bret et al.   Expert Review of Hematology

Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes

(2016) Maria-Paz Garcia-Cuellar et al.   Cell Reports

Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity

(2016) Ayako Ui et al.   Nucleus

Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity

(2016) Ayako Ui et al.   Nucleus

MLL leukemia induction by genome editing of human CD34+ hematopoietic cells

(2015) C. Buechele et al.   BLOOD

Survival regulation of leukemia stem cells

(2015) Yiguo Hu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The diagnostic and clinical impact of genetics and epigenetics in acute myeloid leukemia

(2015) R. S. Ohgami et al.   International Journal of Laboratory Hematology

Transcriptional Elongation Factor ENL Phosphorylated by ATM Recruits Polycomb and Switches Off Transcription for DSB Repair

(2015) Ayako Ui et al.   MOLECULAR CELL

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours

(2015) Elizabeth J. Perlman et al.   Nature Communications

Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential

(2015) Aravinda Kuntimaddi et al.   Cell Reports

Acute Myeloid Leukemia and Myelodysplastic Syndromes in Older Adults

(2014) Heidi D. Klepin et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia

(2014) Jianbiao Zhou   World Journal of Stem Cells

Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks

(2013) René Huber et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In vivo eradication of MLL/ENL leukemia cells by NK cells in the absence of adaptive immunity

(2013) J Nakata et al.   LEUKEMIA

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

A new world of Polycombs: unexpected partnerships and emerging functions

(2013) Yuri B. Schwartz et al.   NATURE REVIEWS GENETICS

MLL-ENL Inhibits Polycomb Repressive Complex 1 to Achieve Efficient Transformation of Hematopoietic Cells

(2013) Emanuel Maethner et al.   Cell Reports

Frat2 mediates the oncogenic activation of Rac by MLL fusions

(2012) V. Walf-Vorderwulbecke et al.   BLOOD

DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo

(2012) Sylvia Takacova et al.   CANCER CELL

The Pathogenesis of Mixed-Lineage Leukemia

(2011) Andrew G. Muntean et al.   Annual Review of Pathology-Mechanisms of Disease

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

(2011) Q.-f. Wang et al.   BLOOD

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

(2011) A. T. Nguyen et al.   BLOOD

The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML

(2011) J. Zhou et al.   BLOOD

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

MLL-ENL leukemia burden initiated in femoral diaphysis and preceded by mature B-cell depletion

(2011) A. Jaracz-Ros et al.   HAEMATOLOGICA

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells

(2010) S. Arai et al.   BLOOD

A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription

(2010) Akihiko Yokoyama et al.   CANCER CELL

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

(2010) M. Mohan et al.   GENES & DEVELOPMENT

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

(2010) Shenghao Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

YEATS domain proteins: a diverse family with many links to chromatin modification and transcriptionThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

(2009) Julia M. Schulze et al.   Biochemistry and Cell Biology

Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C

(2009) M. Schwieger et al.   BLOOD

ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside

(2009) Jianbiao Zhou et al.   Journal of Hematology & Oncology

HOXA9 is required for survival in human MLL-rearranged acute leukemias

(2008) J. Faber et al.   BLOOD

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

(2008) S. J. Horton et al.   BLOOD