Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 71, Issue 1, Pages 63-92Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-013-1322-4
Keywords
Monocytes; Macrophages; Signaling; Transcription; Differentiation
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Funding
- Stiftung fur Pathobiochemie und Molekulare Diagnostik der Deutschen Gesellschaft fur Klinische Chemie und Laboratoriumsmedizin (DGKL)
- Deutsche Forschungsgemeinschaft (DFG) [SFB 566]
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Monocyte/macrophages are important players in orchestrating the immune response as well as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are characterized by the interplay between expansion of stem/progenitor cells and progression towards further developed (myelo)monocytic phenotypes. In response to a variety of differentiation-inducing stimuli, various prominent signaling pathways are activated. Subsequently, specific transcription factors are induced, regulating cell proliferation and maturation. This review article focuses on the integration of signaling modules and transcriptional networks involved in the determination of monocytic differentiation.
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