Frat2 mediates the oncogenic activation of Rac by MLL fusions

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

(2011) B. Mizukawa et al.   BLOOD

The diverse roles of Rac signaling in tumorigenesis

(2011) Natalie A. Mack et al.   CELL CYCLE

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

(2011) B V Balgobind et al.   LEUKEMIA

Rac1 Targeting Suppresses Human Non-Small Cell Lung Adenocarcinoma Cancer Stem Cell Activity

(2011) Shailaja Akunuru et al.   PLoS One

Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo

(2010) A. Sengupta et al.   BLOOD

GSK-3 Promotes Conditional Association of CREB and Its Coactivators with MEIS1 to Facilitate HOX-Mediated Transcription and Oncogenesis

(2010) Zhong Wang et al.   CANCER CELL

β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells

(2010) Jenny Yeung et al.   CANCER CELL

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

(2010) Tim C. P. Somervaille et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12

(2010) Christine J. Harrison et al.   JOURNAL OF CLINICAL ONCOLOGY

Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway

(2010) Christophe Fuerer et al.   PLoS One

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Transformation from Committed Progenitor to Leukemia Stem Cells

(2009) Andrei V. Krivtsov et al.   Annals of the New York Academy of Sciences

Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes

(2009) M J Woodward et al.   CELL DEATH AND DIFFERENTIATION

Rho GTPases in hematopoietic stem cell functions

(2009) Jose A Cancelas et al.   CURRENT OPINION IN HEMATOLOGY

Wnt signaling pathways meet Rho GTPases

(2009) K. Schlessinger et al.   GENES & DEVELOPMENT

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

(2009) P. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways

(2009) R van Amerongen et al.   ONCOGENE

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

(2008) S. J. Horton et al.   BLOOD

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

(2008) Junping Wei et al.   CANCER CELL

Rac guanosine triphosphatases represent a potential target in AML

(2008) L U W Müller et al.   LEUKEMIA

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

(2008) Zhong Wang et al.   NATURE

Molecular association between β-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/β-catenin signaling

(2008) G Upadhyay et al.   ONCOGENE