Acute Myeloid Leukemia and Myelodysplastic Syndromes in Older Adults

Validation of the revised International Prognostic Scoring System in treated patients with myelodysplastic syndromes

(2013) Asmita Mishra et al.   AMERICAN JOURNAL OF HEMATOLOGY

Outcomes in Patients Age 70 or Older Undergoing Allogeneic Hematopoietic Stem Cell Transplantation for Hematologic Malignancies

(2013) Andrew M. Brunner et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival

(2013) A. K. Burnett et al.   BLOOD

Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia

(2013) H. D. Klepin et al.   BLOOD

Survival and cure of acute myeloid leukaemia in England, 1971-2006: a population-based study

(2013) Anjali Shah et al.   BRITISH JOURNAL OF HAEMATOLOGY

Outcome of older patients with acute myeloid leukemia

(2013) Mya S. Thein et al.   CANCER

Lenalidomide performance in the real world

(2013) Amer M. Zeidan et al.   CANCER

Intensive induction is effective in selected octogenarian acute myeloid leukemia patients: prognostic significance of karyotype and selected molecular markers used in the European LeukemiaNet classification

(2013) M. Wetzler et al.   HAEMATOLOGICA

Sorafenib in Combination With Intensive Chemotherapy in Elderly Patients With Acute Myeloid Leukemia: Results From a Randomized, Placebo-Controlled Trial

(2013) Hubert Serve et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem-Cell Transplantation in Older Patients With De Novo Myelodysplastic Syndromes: An International Collaborative Decision Analysis

(2013) John Koreth et al.   JOURNAL OF CLINICAL ONCOLOGY

Revised International Prognostic Scoring System (IPSS) Predicts Survival and Leukemic Evolution of Myelodysplastic Syndromes Significantly Better Than IPSS and WHO Prognostic Scoring System: Validation by the Gruppo Romano Mielodisplasie Italian Regional Database

(2013) Maria Teresa Voso et al.   JOURNAL OF CLINICAL ONCOLOGY

Significant Improvement in Survival After Allogeneic Hematopoietic Cell Transplantation During a Period of Significantly Increased Use, Older Recipient Age, and Use of Unrelated Donors

(2013) Theresa Hahn et al.   JOURNAL OF CLINICAL ONCOLOGY

Epigenetics Meets Genetics in Acute Myeloid Leukemia: Clinical Impact of a Novel Seven-Gene Score

(2013) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission

(2013) Mona Hassanein et al.   LEUKEMIA RESEARCH

Geriatric assessment in older patients with acute myeloid leukemia: A retrospective study of associated treatment and outcomes

(2013) Alexander E. Sherman et al.   LEUKEMIA RESEARCH

Long-term outcome of higher-risk MDS patients treated with azacitidine: an update of the GFM compassionate program cohort

(2012) R. Itzykson et al.   BLOOD

Revised International Prognostic Scoring System for Myelodysplastic Syndromes

(2012) P. L. Greenberg et al.   BLOOD

The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML

(2012) Alan K. Burnett et al.   BRITISH JOURNAL OF HAEMATOLOGY

Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome

(2012) B. Deschler et al.   HAEMATOLOGICA

Survival for older patients with acute myeloid leukemia: a population-based study

(2012) B. Oran et al.   HAEMATOLOGICA

Pretreatment risk factors and importance of comorbidity for overall survival, complete remission, and early death in patients with acute myeloid leukemia

(2012) Irena Djunic et al.   Hematology

Prognostic Significance of the European LeukemiaNet Standardized System for Reporting Cytogenetic and Molecular Alterations in Adults With Acute Myeloid Leukemia

(2012) Krzysztof Mrózek et al.   JOURNAL OF CLINICAL ONCOLOGY

Addition of Gemtuzumab Ozogamicin to Induction Chemotherapy Improves Survival in Older Patients With Acute Myeloid Leukemia

(2012) Alan K. Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia

(2012) Hagop M. Kantarjian et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study

(2012) Sylvie Castaigne et al.   LANCET

A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy

(2012) Shabbir M.H. Alibhai et al.   LEUKEMIA RESEARCH

Older age is associated with similar quality of life and physical function compared to younger age during intensive chemotherapy for acute myeloid leukemia

(2012) H. Mohamedali et al.   LEUKEMIA RESEARCH

The impact of hypomethylating agents on the cost of care and survival of elderly patients with myelodysplastic syndromes

(2012) Rong Wang et al.   LEUKEMIA RESEARCH

Health-related quality of life outcomes of lenalidomide in transfusion-dependent patients with Low- or Intermediate-1-risk myelodysplastic syndromes with a chromosome 5q deletion: Results from a randomized clinical trial

(2012) Dennis A. Revicki et al.   LEUKEMIA RESEARCH

Comparison of Reduced-Intensity Hematopoietic Cell Transplantation with Chemotherapy in Patients Age 60-70 Years with Acute Myelogenous Leukemia in First Remission

(2011) Sherif S. Farag et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Most 70- to 79-year-old patients with acute myeloid leukemia do benefit from intensive treatment

(2011) G. Juliusson et al.   BLOOD

A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q

(2011) P. Fenaux et al.   BLOOD

Lenalidomide in lower-risk myelodysplastic syndromes with karyotypes other than deletion 5q and refractory to erythropoiesis-stimulating agents

(2011) David Sibon et al.   BRITISH JOURNAL OF HAEMATOLOGY

Association of Comorbidities With Overall Survival in Myelodysplastic Syndrome: Development of a Prognostic Model

(2011) Kiran Naqvi et al.   JOURNAL OF CLINICAL ONCOLOGY

The Feasibility of Inpatient Geriatric Assessment for Older Adults Receiving Induction Chemotherapy for Acute Myelogenous Leukemia

(2011) Heidi D. Klepin et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

The hematopoietic cell transplantation comorbidity index is a predictor of early death and survival in adult acute myeloid leukemia patients

(2011) Aleksandar Savic et al.   LEUKEMIA RESEARCH

Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia

(2010) H. Kantarjian et al.   BLOOD

A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial

(2010) C. Rollig et al.   BLOOD

Effects of azacitidine compared with conventional care regimens in elderly (≥75 years) patients with higher-risk myelodysplastic syndromes

(2010) John F. Seymour et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Risk stratification based on both disease status and extra-hematologic comorbidities in patients with myelodysplastic syndrome

(2010) M. G. Della Porta et al.   HAEMATOLOGICA

Effect of Age on Outcome of Reduced-Intensity Hematopoietic Cell Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission or With Myelodysplastic Syndrome

(2010) Brian L. McClune et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Study of Intensified Anthracycline Doses for Induction and Recombinant Interleukin-2 for Maintenance in Patients With Acute Myeloid Leukemia Age 50 to 70 Years: Results of the ALFA-9801 Study

(2010) Cecile Pautas et al.   JOURNAL OF CLINICAL ONCOLOGY

Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes

(2010) Utz Krug et al.   LANCET

Exercise for older adult inpatients with acute myelogenous leukemia: A pilot study

(2010) Heidi D. Klepin et al.   Journal of Geriatric Oncology

Prognostic factor analysis of the survival of elderly patients with AML in the MRC AML11 and LRF AML14 trials

(2009) Keith Wheatley et al.   BRITISH JOURNAL OF HAEMATOLOGY

Comorbidities and FLT3-ITD abnormalities as independent prognostic indicators of survival in Elderly acute myeloid leukaemia patients

(2009) Massimo Breccia et al.   HEMATOLOGICAL ONCOLOGY

Age-Specific Differences in Oncogenic Pathway Dysregulation in Patients With Acute Myeloid Leukemia

(2009) Arati V. Rao et al.   JOURNAL OF CLINICAL ONCOLOGY

Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia

(2009) Pierre Fenaux et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

High-Dose Daunorubicin in Older Patients with Acute Myeloid Leukemia

(2009) Bob Löwenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Erythropoiesis-stimulating agents in the treatment of anemia in myelodysplastic syndromes: a meta-analysis

(2008) Victor Moyo et al.   ANNALS OF HEMATOLOGY

Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry

(2008) G. Juliusson et al.   BLOOD

Efficacy and safety of lenalidomide in intermediate-2 or high-risk myelodysplastic syndromes with 5q deletion: results of a phase 2 study

(2008) L. Ades et al.   BLOOD

Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs

(2008) D. E. Rollison et al.   BLOOD

Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia

(2008) Sebastian Scholl et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Erythropoietin and Granulocyte-Colony Stimulating Factor Treatment Associated With Improved Survival in Myelodysplastic Syndrome

(2008) Martin Jädersten et al.   JOURNAL OF CLINICAL ONCOLOGY

Predictive factors of response and survival in myelodysplastic syndrome treated with erythropoietin and G-CSF: the GFM experience

(2007) S. Park et al.   BLOOD

Prognostic value of immunophenotyping in elderly patients with acute myeloid leukemia

(2007) Claudiu Plesa et al.   CANCER