Dynamic droplets: the role of cytoplasmic inclusions in stress, function, and disease

Probing the Stochastic, Motor-Driven Properties of the Cytoplasm Using Force Spectrum Microscopy

(2014) Ming Guo et al.   CELL

The mystery of aging and rejuvenation—a budding topic

(2014) Thomas Nyström et al.   CURRENT OPINION IN MICROBIOLOGY

Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases

(2014) C. I. Nussbaum-Krammer et al.   Disease Models & Mechanisms

Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance

(2014) D. Oling et al.   EMBO JOURNAL

Misfolded Polyglutamine, Polyalanine, and Superoxide Dismutase 1 Aggregate via Distinct Pathways in the Cell

(2014) Saskia Polling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor

(2014) L. Liu-Yesucevitz et al.   JOURNAL OF NEUROSCIENCE

The nematode Caenorhabditis elegans: A versatile model for the study of proteotoxicity and aging

(2014) Yuli Volovik et al.   METHODS

Proteasome Failure Promotes Positioning of Lysosomes around the Aggresome via Local Block of Microtubule-Dependent Transport

(2014) N. Zaarur et al.   MOLECULAR AND CELLULAR BIOLOGY

Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules

(2014) Ouissame Bounedjah et al.   NUCLEIC ACIDS RESEARCH

Protein aggregation and prionopathies

(2014) M. Renner et al.   PATHOLOGIE BIOLOGIE

Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin

(2014) M. Ogrodnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A

(2014) K. P. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clogging information flow in ALS

(2014) J. W. Paul et al.   SCIENCE

Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae

(2014) S. M. Hill et al.   SCIENCE

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans

(2014) Frederick B. Shipley et al.   Frontiers in Neural Circuits

DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson’s disease

(2014) L Zondler et al.   Cell Death & Disease

Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease

(2014) Sandra Tenreiro et al.   PLoS Genetics

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates

(2014) Jia Song et al.   PLoS Genetics

A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

(2014) Lori Clay et al.   eLife

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

(2014) Ivana Petrovska et al.   eLife

Quantitative fluorescence loss in photobleaching for analysis of protein transport and aggregation

(2013) Daniel Wüstner et al.   BMC BIOINFORMATICS

The Bacterial Cytoplasm Has Glass-like Properties and Is Fluidized by Metabolic Activity

(2013) Bradley R. Parry et al.   CELL

Cellular maintenance of nuclear protein homeostasis

(2013) Pamela S. Gallagher et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aging: Filtering Out Bad Mitochondria

(2013) Thomas Nyström   CURRENT BIOLOGY

Fission Yeast Does Not Age under Favorable Conditions, but Does So after Stress

(2013) Miguel Coelho et al.   CURRENT BIOLOGY

Protein quality control in time and space - links to cellular aging

(2013) Thomas Nyström et al.   FEMS YEAST RESEARCH

Substrate Recognition in Nuclear Protein Quality Control Degradation Is Governed by Exposed Hydrophobicity That Correlates with Aggregation and Insolubility

(2013) Eric K. Fredrickson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The asymmetric segregation of damaged proteins is stem cell–type dependent

(2013) Mary Rose Bufalino et al.   JOURNAL OF CELL BIOLOGY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology

(2013) Sibylle E. Eisbach et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis

(2013) P. A. Parone et al.   JOURNAL OF NEUROSCIENCE

Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

(2013) Ayala Shiber et al.   MOLECULAR BIOLOGY OF THE CELL

Conformational templating of α-synuclein aggregates in neuronal-glial cultures

(2013) Amanda N Sacino et al.   Molecular Neurodegeneration

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

(2013) Hyung-Jun Kim et al.   NATURE GENETICS

Human superoxide dismutase 1 overexpression in motor neurons of Caenorhabditis elegans causes axon guidance defect and neurodegeneration

(2013) Jia Li et al.   NEUROBIOLOGY OF AGING

The Type II Hsp40 Sis1 Cooperates with Hsp70 and the E3 Ligase Ubr1 to Promote Degradation of Terminally Misfolded Cytosolic Protein

(2013) Daniel W. Summers et al.   PLoS One

Mutant Huntingtin Gene-Dose Impacts on Aggregate Deposition, DARPP32 Expression and Neuroinflammation in HdhQ150 Mice

(2013) Douglas Young et al.   PLoS One

Germ Plasm Anchoring Is a Dynamic State that Requires Persistent Trafficking

(2013) Kristina S. Sinsimer et al.   Cell Reports

4D Imaging of Protein Aggregation in Live Cells

(2013) Rachel Spokoini et al.   Jove-Journal of Visualized Experiments

Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions

(2012) Michael P. Hart et al.   ACTA NEUROPATHOLOGICA

SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on Sir2-mediated mitophagy

(2012) Belém Sampaio-Marques et al.   Autophagy

Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast

(2012) Erwin Swinnen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients

(2012) Morgan E. DeSantis et al.   CELL

Getting RNA and Protein in Phase

(2012) Stephanie C. Weber et al.   CELL

A yeast model for amyloid-  aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity

(2012) F. D'Angelo et al.   Disease Models & Mechanisms

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis

(2012) Julien Couthouis et al.   HUMAN MOLECULAR GENETICS

Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains

(2012) Hongfeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Potentially Toxic Oligomers Formedin Vitrofrom Mammalian-derived Expanded huntingtin Exon-1 Protein

(2012) Leslie G. Nucifora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component

(2012) Sebastian Treusch et al.   JOURNAL OF CELL BIOLOGY

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity

(2012) Dmitry Kryndushkin et al.   MOLECULAR MICROBIOLOGY

TDP-43 and FUS/TLS yield a target-rich haul in ALS

(2012) Aaron D Gitler   NATURE NEUROSCIENCE

Ultrastructure of ubiquitin-positive, TDP-43-negative neuronal inclusions in cerebral cortex of C9ORF72-linked frontotemporal lobar degeneration/amyotrophic lateral sclerosis

(2012) Wenlang Lin et al.   NEUROPATHOLOGY

Patterns of [PSI+] aggregation allow insights into cellular organization of yeast prion aggregates

(2012) Jens Tyedmers   Prion

Molecular mechanisms of spatial protein quality control

(2012) Simon Alberti   Prion

Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

(2012) S. J. Weisberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonthermal ATP-dependent fluctuations contribute to the in vivo motion of chromosomal loci

(2012) S. C. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Human Disease

(2012) A. D. Gitler et al.   SCIENCE

Quality Control Compartments Coming of Age

(2012) Tziona Ben-Gedalya et al.   TRAFFIC

Confinement to Organelle-Associated Inclusion Structures Mediates Asymmetric Inheritance of Aggregated Protein in Budding Yeast

(2012) Rachel Spokoini et al.   Cell Reports

Role of Water in Protein Aggregation and Amyloid Polymorphism

(2011) D. Thirumalai et al.   ACCOUNTS OF CHEMICAL RESEARCH

Segregation of Protein Aggregates Involves Actin and the Polarity Machinery

(2011) Beidong Liu et al.   CELL

Amyloid deposits: Protection against toxic protein species?

(2011) Sebastian Treusch et al.   CELL CYCLE

Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm

(2011) Anthony A. Hyman et al.   DEVELOPMENTAL CELL

Ordered Assembly of Heat Shock Proteins, Hsp26, Hsp70, Hsp90, and Hsp104, on Expanded Polyglutamine Fragments Revealed by Chemical Probes

(2011) Gladis M. Walter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments

(2011) T. Ben-Gedalya et al.   JOURNAL OF CELL SCIENCE

Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-Length Polyglutamine Expansions Are a Risk Factor for ALS

(2011) Nancy M. Bonini et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Local RNA Translation at the Synapse and in Disease

(2011) L. Liu-Yesucevitz et al.   JOURNAL OF NEUROSCIENCE

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast

(2011) Vydehi Kanneganti et al.   MOLECULAR BIOLOGY OF THE CELL

Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states

(2011) Mercedes Prudencio et al.   Molecular Neurodegeneration

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

(2011) A. J. Ehrlicher et al.   NATURE

RNA-binding proteins with prion-like domains in ALS and FTLD-U

(2011) Aaron D. Gitler et al.   Prion

Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

(2011) Zhihui Sun et al.   PLOS BIOLOGY

α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease

(2010) Pavan K. Auluck et al.   Annual Review of Cell and Developmental Biology

Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes

(2010) Susan M Baker et al.   BMC CELL BIOLOGY

Polyglutamine shows a urea-like affinity for unfolded cytosolic protein

(2010) Jeremy L. England et al.   FEBS LETTERS

Quantitative Relationships between Huntingtin Levels, Polyglutamine Length, Inclusion Body Formation, and Neuronal Death Provide Novel Insight into Huntington's Disease Molecular Pathogenesis

(2010) J. Miller et al.   JOURNAL OF NEUROSCIENCE

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Ageing and protein aggregation-mediated disorders: from invertebrates to mammals

(2010) A. Dillin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

(2010) J. Tyedmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prions, protein homeostasis, and phenotypic diversity

(2010) Randal Halfmann et al.   TRENDS IN CELL BIOLOGY

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.

(2009) Brian S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS

(2009) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

(2008) James Shorter et al.   EMBO JOURNAL

Interaction of Amyotrophic Lateral Sclerosis (ALS)-related Mutant Copper-Zinc Superoxide Dismutase with the Dynein-Dynactin Complex Contributes to Inclusion Formation

(2008) Anna-Lena Ström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triggering Aggresome Formation

(2008) Nava Zaarur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic diffusion: molecular motors mix it up

(2008) Clifford P. Brangwynne et al.   JOURNAL OF CELL BIOLOGY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

Formation of Toxic Oligomeric α-Synuclein Species in Living Cells

(2008) Tiago Fleming Outeiro et al.   PLoS One

Selective benefits of damage partitioning in unicellular systems and its effects on aging

(2008) N. Erjavec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric mitosis: Unequal segregation of proteins destined for degradation

(2008) L. C. Fuentealba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-dependent amyloid assembly protects cells from prion toxicity

(2008) P. M. Douglas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation

(2008) A. B. Lindner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

(2008) B. S. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA