Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast

The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates

(2010) Beidong Liu et al.   CELL

Apoptosis in yeast: triggers, pathways, subroutines

(2010) D Carmona-Gutierrez et al.   CELL DEATH AND DIFFERENTIATION

Simple is good: yeast models of neurodegeneration

(2010) Sandra Tenreiro et al.   FEMS YEAST RESEARCH

Synphilin-1 attenuates neuronal degeneration in the A53T  -synuclein transgenic mouse model

(2010) W. W. Smith et al.   HUMAN MOLECULAR GENETICS

Can autophagy promote longevity?

(2010) Frank Madeo et al.   NATURE CELL BIOLOGY

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

(2010) Vikram Khurana et al.   NATURE REVIEWS NEUROSCIENCE

Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner

(2010) Sabrina Büttner et al.   PLoS One

Protein Misfolding and Aggregation in Parkinson's Disease

(2009) Jeanne M.M. Tan et al.   ANTIOXIDANTS & REDOX SIGNALING

Yeast unfolds the road map toward α-synuclein-induced cell death

(2009) V Franssens et al.   CELL DEATH AND DIFFERENTIATION

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

(2009) L. J. Su et al.   Disease Models & Mechanisms

Interaction with synphilin-1 promotes inclusion formation of α-synuclein: mechanistic insights and pathological implication

(2009) Yuan-Yuan Xie et al.   FASEB JOURNAL

Synphilin-1A Inhibits Seven in Absentia Homolog (SIAH) and Modulates α-Synuclein Monoubiquitylation and Inclusion Formation

(2009) Raymonde Szargel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice

(2009) Silke Nuber et al.   NEUROGENETICS

Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson

(2008) Piotr Zabrocki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Triggering Aggresome Formation

(2008) Nava Zaarur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Mitochondria Are Required for α-Synuclein Toxicity in Aging Yeast

(2008) Sabrina Büttner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors

(2008) Antje Krenz et al.   JOURNAL OF NEUROCHEMISTRY

α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae

(2008) James H. Soper et al.   MOLECULAR BIOLOGY OF THE CELL

Synphilin-1 transgenic mice exhibit mild motor impairments

(2008) Hong-Guo Jin et al.   NEUROSCIENCE LETTERS