Senescence suppressors: their practical importance in replicative lifespan extension in stem cells

miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

(2016) Laura R. Saunders et al.   Aging-US

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

(2014) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

The modulation of the oxidative stress response in chondrocytes by Wip1 and its effect on senescence and dedifferentiation during in vitro expansion

(2013) Byung-Hyun Cha et al.   BIOMATERIALS

Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells

(2013) Nicola Alessio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety

(2013) Robert J. Fox et al.   CURRENT MEDICAL RESEARCH AND OPINION

Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53/p21 pathway

(2013) Fernanda Augusta de Lima Barbosa Guterres et al.   EXPERIMENTAL CELL RESEARCH

Sulforaphane enhances the activity of the Nrf2–ARE pathway and attenuates inflammation in OxyHb-induced rat vascular smooth muscle cells

(2013) X.-D. Zhao et al.   INFLAMMATION RESEARCH

Do sirtuins promote mammalian longevity?: A Critical review on its relevance to the longevity effect induced by calorie restriction

(2013) Seongjoon Park et al.   MOLECULES AND CELLS

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

SOD1 and DJ-1 Converge at Nrf2 Pathway: A Clue for Antioxidant Therapeutic Potential in Neurodegeneration

(2013) Pamela Milani et al.   Oxidative Medicine and Cellular Longevity

Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease

(2013) Samantha Giordano et al.   Redox Biology

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

(2012) Jun Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Potential Therapeutic Effects of Natural Heme Oxygenase-1 Inducers in Cardiovascular Diseases

(2012) Ignazio Barbagallo et al.   ANTIOXIDANTS & REDOX SIGNALING

Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromal cells in prolonged culture expansion

(2012) Li Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production

(2012) Sun Ah Ham et al.   BIOCHEMICAL JOURNAL

The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent

(2012) Min Young Kim et al.   BIOCHEMICAL PHARMACOLOGY

Human adipose-derived mesenchymal stem cells: serial passaging, doubling time and cell senescence

(2012) HE Gruber et al.   BIOTECHNIC & HISTOCHEMISTRY

Activation of nuclear factor erythroid 2-related factor 2 and PPARγ plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury

(2012) Ting Zhang et al.   BRITISH JOURNAL OF NUTRITION

Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ

(2012) Stefania Briganti et al.   EXPERIMENTAL DERMATOLOGY

Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment

(2012) Eugenio Barone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging

(2012) Sarah J. Chapple et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nicotinamide-induced Mitophagy

(2012) So-young Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aging Effect on Neurotrophic Activity of Human Mesenchymal Stem Cells

(2012) Maria Brohlin et al.   PLoS One

A Small Molecule Modulator of Prion Protein Increases Human Mesenchymal Stem Cell Lifespan, Ex Vivo Expansion, and Engraftment to Bone Marrow in NOD/SCID Mice

(2012) Sindhu T. Mohanty et al.   STEM CELLS

Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells

(2011) Hyo Jung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene

(2011) Shuntaro Yamashita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1β in osteoarthritic osteoblasts

(2011) Victoria Clérigues et al.   BIOCHEMICAL PHARMACOLOGY

PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney

(2011) Hyun Ae Lim et al.   BIOGERONTOLOGY

Differentiation of human umbilical cord mesenchymal stem cells into hepatocyte-like cells by hTERT gene transfectionin vitro

(2011) Xu‑Jing Liang et al.   CELL BIOLOGY INTERNATIONAL

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

(2011) J C Estrada et al.   CELL DEATH AND DIFFERENTIATION

Cartilage Matrix Formation by Bovine Mesenchymal Stem Cells in Three-dimensional Culture Is Age-dependent

(2011) Isaac E. Erickson et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Biliverdin reductase A in the prevention of cellular senescence against oxidative stress

(2011) Sung Young Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix

(2011) Yun Sun et al.   FASEB JOURNAL

PPARδ Coordinates Angiotensin II-induced Senescence in Vascular Smooth Muscle Cells through PTEN-mediated Inhibition of Superoxide Generation

(2011) Hyo Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression

(2011) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence

(2011) Heike Helmbold et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SIRT1 is required for long-term growth of human mesenchymal stem cells

(2011) Hong-Feng Yuan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Klotho suppresses RIG-I-mediated senescence-associated inflammation

(2011) Feng Liu et al.   NATURE CELL BIOLOGY

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

(2011) A. Menssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix

(2010) Hae Ri Choi et al.   AGING CELL

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

(2010) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway

(2010) Hidetaka Ota et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Improved proliferation and differentiation capacity of human mesenchymal stromal cells cultured with basement-membrane extracellular matrix proteins

(2010) Ulrich Lindner et al.   CYTOTHERAPY

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 contributes to telomere maintenance and augments global homologous recombination

(2010) Jose A. Palacios et al.   JOURNAL OF CELL BIOLOGY

Modulation of vascular endothelial cell senescence by integrin β4

(2010) ChunHui Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

(2010) Shinji Kume et al.   JOURNAL OF CLINICAL INVESTIGATION

Sulforaphane and α-Lipoic Acid Upregulate the Expression of the π Class of Glutathione S-Transferase through c-Jun and Nrf2 Activation

(2010) Chong-Kuei Lii et al.   JOURNAL OF NUTRITION

Bmi-1 regulates self-renewal, proliferation and senescence of human fetal neural stem cells in vitro

(2010) Yang Wang et al.   NEUROSCIENCE LETTERS

The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB–P53 pathways

(2010) N Alessio et al.   ONCOGENE

Haem oxygenase-1 down-regulates high mobility group box 1 and matrix metalloproteinases in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   RHEUMATOLOGY

SirT1—A Sensor for Monitoring Self-Renewal and Aging Process in Retinal Stem Cells

(2010) Chi-Hsien Peng et al.   SENSORS

Bmi-1, stem cells and cancer

(2009) L. Jiang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

Nicotinamide enhances mitochondria quality through autophagy activation in human cells

(2009) Hyun Tae Kang et al.   AGING CELL

Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo

(2009) Shenghui He et al.   DEVELOPMENTAL BIOLOGY

SIRT1 markedly extends replicative lifespan if the NAD+salvage pathway is enhanced

(2009) Cynthia Ho et al.   FEBS LETTERS

Overexpression of heme oxygenase-1 increases human osteoblast stem cell differentiation

(2009) Ignazio Barbagallo et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Design, Synthesis, and Structure−Activity Relationship of Indole-3-glyoxylamide Libraries Possessing Highly Potent Activity in a Cell Line Model of Prion Disease

(2009) Mark J. Thompson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The PPAR  Agonist Pioglitazone Ameliorates Aging-Related Progressive Renal Injury

(2009) H.-C. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Senescent Growth Arrest in Mesenchymal Stem Cells Is Bypassed by Wip1-Mediated Downregulation of Intrinsic Stress Signaling Pathways

(2009) Ji-Seon Lee et al.   STEM CELLS

Reconstitution of Marrow-Derived Extracellular Matrix Ex Vivo: A Robust Culture System for Expanding Large-Scale Highly Functional Human Mesenchymal Stem Cells

(2009) Yanlai Lai et al.   STEM CELLS AND DEVELOPMENT

Redox Regulation of Stem and Progenitor Cells

(2008) Laura S. Haneline   ANTIOXIDANTS & REDOX SIGNALING

Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation ofHO-1gene expression by haematin

(2008) Cicerone Tudor et al.   BIOCHEMICAL JOURNAL

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

The octarepeat region of prion protein, but not the TM1 domain, is important for the antioxidant effect of prion protein

(2008) Muriel Malaisé et al.   FREE RADICAL BIOLOGY AND MEDICINE

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Klotho is a target gene of PPAR-γ

(2008) Hong Zhang et al.   KIDNEY INTERNATIONAL

Neurogenesis directed by Sirt1

(2008) Sergiy Libert et al.   NATURE CELL BIOLOGY

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

(2008) Timour Prozorovski et al.   NATURE CELL BIOLOGY

Sirtuins — novel therapeutic targets to treat age-associated diseases

(2008) Siva Lavu et al.   NATURE REVIEWS DRUG DISCOVERY

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

(2008) Jing Huang et al.   PLoS One

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

(2008) K. Abdelmohsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-β1 Is a Molecular Target for the Peroxisome Proliferator-Activated Receptor δ

(2007) Hyo Jung Kim et al.   CIRCULATION RESEARCH

Age-related changes in human bone marrow-derived mesenchymal stem cells: Consequences for cell therapies

(2007) A. Stolzing et al.   MECHANISMS OF AGEING AND DEVELOPMENT