SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

(2016) Michael C. Velarde et al.   Aging-US

Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis

(2013) Arwa S. Kathiria et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD

(2013) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway

(2013) Jae-Woong Hwang et al.   FASEB JOURNAL

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic Gene Expression Profiling in Nrf2 Knockout Mice after Long-Term High-Fat Diet-Induced Obesity

(2013) Dionysios V. Chartoumpekis et al.   Oxidative Medicine and Cellular Longevity

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

(2012) Hongwei Yao et al.   BIOCHEMICAL PHARMACOLOGY

Mononuclear Iron Enzymes Are Primary Targets of Hydrogen Peroxide Stress

(2012) Adil Anjem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells

(2012) Reas S. Khan et al.   Frontiers in Cellular Neuroscience

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

(2011) J.-w. Hwang et al.   JOURNAL OF IMMUNOLOGY

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease

(2011) Irfan Rahman et al.   PREVENTIVE MEDICINE

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Redox Regulation of Sirtuin-1 by S-Glutathiolation

(2010) Rebecca S. Zee et al.   ANTIOXIDANTS & REDOX SIGNALING

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

(2010) Albena T. Dinkova-Kostova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction

(2010) David Adenuga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice

(2010) Eric J. Marrotte et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme Oxygenase-1 Inhibits Renal Tubular Macroautophagy in Acute Kidney Injury

(2010) S. Bolisetty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM

(2010) H. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

(2009) Tirumalai Rangasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lipid peroxidation products as oxidative stress biomarkers

(2009) Etsuo Niki   BIOFACTORS

Oxidative Damage to Nucleic Acids in Severe Emphysema

(2009) Gaetan Deslee et al.   CHEST

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice

(2008) Hongwei Yao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung Function Loss, Smoking, Vitamin C Intake, and Polymorphisms of the Glutamate-Cysteine Ligase Genes

(2008) Mateusz Siedlinski et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1

(2008) Deepti Malhotra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

(2007) Aruna Kode et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY