Article
Medicine, Research & Experimental
Metee Iampanichakul, Prapassorn Potue, Siwayu Rattanakanokchai, Putcharawipa Maneesai, Juthamas Khamseekaew, Wannapa Settheetham-Ishida, Poungrat Pakdeechote
Summary: This study found that limonin has a beneficial effect on cardiovascular abnormalities in nitric oxide-deficient rats. Limonin can reduce hypertension, improve cardiovascular function, and remodel cardiac tissue. The mechanism of action involves the modulation of proteins related to the renin-angiotensin system, oxidative stress, and inflammation.
Article
Critical Care Medicine
Jinghong Zhao, Jilin Hu, Rongyi Zhang, Jianping Deng
Summary: CEBPD promotes miR-96-5p-mediated negative regulation of IP3R expression to inhibit oxidative stress and inflammation, thereby alleviating hypertensive cardiac remodeling.
Article
Pharmacology & Pharmacy
Liangqingqing Yin, Jie Bai, Wei-Jia Yu, Ying Liu, Hui-Hua Li, Qiu-Yue Lin
Summary: The adhesion of monocytes to the vascular endothelium is an important factor in inflammatory response and contributes to hypertension and vascular remodeling. The role of VCAM-1 in Ang II-induced hypertension and vascular dysfunction is not well understood. Blocking VCAM-1 with a neutralizing antibody can alleviate these effects and represents a novel therapeutic approach for hypertension.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Irakli Kopaliani, Natalia Jarzebska, Silke Billoff, Anne Kolouschek, Jens Martens-Lobenhoffer, Stefan R. Bornstein, Stefanie M. Bode-Boeger, Vinitha N. Ragavan, Norbert Weiss, Arduino A. Mangoni, Andreas Deussen, Roman N. Rodionov
Summary: In this study, overexpression of dimethylarginine dimethylaminohydrolase 1 (DDAH1) was found to protect against angiotensin II-induced cardiovascular damage, progression of hypertension, and adverse vascular remodeling in vivo. This protective effect is associated with decreased levels of asymmetric dimethylarginine, preservation of endothelial function, inhibition of cardiovascular inflammation, and lower activity of matrix metalloproteinase-2. The findings suggest that upregulation of DDAH1 might be a promising therapeutic approach against angiotensin II-induced end organ damage.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Eduardo Vieira Da Rocha, Francisco Falchetti, Laena Pernomian, Marcela M. Blascke De Mello, Juliana M. M. Parente, Renato C. C. Nogueira, Beatriz Q. Q. Gomes, Giuliana Bertozi, Jessica M. M. Sanches-Lopes, Jose Eduardo Tanus-Santos, Michele M. M. Castro
Summary: This study found that the use of quercetin in hypertensive rats can reduce oxidative stress and MMP activity, as well as improve hypertrophic vascular remodeling. However, quercetin did not improve cardiac hypertrophy and dysfunction.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Pei Qian, Qian Wang, Fang-Zheng Wang, Hang-Bing Dai, Hong-Yu Wang, Qing Gao, Hong Zhou, Ye-Bo Zhou
Summary: This study aimed to investigate the protective role of adrenomedullin (ADM) in cardiac remodeling and function in obesity-related hypertension (OH) rats. The results showed that ADM improved systemic inflammation and oxidative stress in OH rats, and had inhibitory effects on cardiac inflammation and oxidative stress. ADM also improved cardiac remodeling and function in OH rats.
Article
Engineering, Biomedical
Yanxin Zhang, Xin Li, Zhaowenbin Zhang, Huili Li, Dongmin Chen, Yiren Jiao, Chen Fan, Zhen Zeng, Jiang Chang, Yuhong Xu, Baowei Peng, Chen Yang, Yumei Que
Summary: This study developed a Zn2SiO4 bioceramic that can release bioactive SiO32- and Zn2+ ions simultaneously, which have synergistic effects on promoting endothelial cell angiogenesis, inhibiting cardiomyocyte apoptosis, and protecting myocardial mitochondria against reactive oxygen species-induced injury. In vivo outcomes from a murine MI model demonstrated that systemic administration or local application of the Zn2SiO4 extract or composite hydrogel promoted cardiac function and reduced cardiac fibrosis, aiding myocardial repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Francisco Olivares-Silva, Nicole De Gregorio, Jenaro Espitia-Corredor, Claudio Espinoza, Raul Vivar, David Silva, Jose Miguel Osorio, Sergio Lavandero, Concepcion Peiro, Carlos Sanchez-Ferrer, Guillermo Diaz-Araya
Summary: Resolvin-D1 (RvD1) attenuates cardiac remodeling and hypertension induced by angiotensin II by reducing inflammation, cytokine levels, cardiac hypertrophy, fibrosis, and blood pressure, demonstrating novel cardioprotective effects.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Drew Theobald, Anand R. Nair, Srinivas Sriramula, Joseph Francis
Summary: Toll-like receptor 4 (TLR4) plays a crucial role in the innate immune response and cardiovascular diseases. This study found that cardiomyocyte-specific deletion of TLR4 provides protection against hypertension, cardiac hypertrophy, and remodeling. The results showed that in mice with cardiomyocyte-specific TLR4 knockdown, angiotensin II-induced hypertension and cardiac hypertrophy were attenuated, myocardial fibrosis was reduced, and cardiac function was improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biology
Carolina B. A. Restini, Arthur F. E. Garcia, Henrique M. Natalin, Mariane F. A. Carmo, Vinicius F. Nowicki, Elen Rizzi, Leandra N. Z. Ramalho
Summary: Resveratrol alone or in combination with captopril can provide protective effects against cardiac damage and remodeling caused by renovascular hypertension.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Shaowei Fan, Yuanhui Hu, Yaping You, Wenjing Xue, Ruoning Chai, Xuesong Zhang, Xintian Shou, Jingjing Shi
Summary: Cardiovascular disease is a group of diseases with high mortality. Pathological cardiac remodeling is the most common cardiac pathological change, and inhibiting it can delay the development of cardiovascular diseases. Resveratrol, a polyphenol compound, has various cardiovascular protective effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Putcharawipa Maneesai, Nisita Chaihongsa, Metee Iampanichakul, Sariya Meephat, Patoomporn Prasatthong, Sarawoot Bunbupha, Chutamas Wunpathe, Poungrat Pakdeechote
Summary: The study showed that the extract of Clitoria ternatea had antihypertensive effects in rats with improved vascular function and cardiac hypertrophy, possibly by suppressing the renin-angiotensin system, oxidative stress, and the AT(1)R/TGF-beta 1 cascade.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Medicine, Research & Experimental
Qing Peng, Ruilin Ding, Xiaojie Wang, Ping Yang, Feng Jiang, Xiaoping Chen
Summary: This study demonstrates that irisin can improve cardiac remodeling by inhibiting oxidative stress and attenuating the activation of the Akt signaling pathway. These findings provide important insights for exploring new therapeutic approaches for cardiac diseases.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ze-Yang Qiu, Wei-Jia Yu, Jie Bai, Qiu-Yue Lin
Summary: Blocking VCAM-1 can improve hypertensive cardiac remodeling by reducing macrophage infiltration. This study's findings may provide a novel therapeutic strategy for hypertensive cardiac diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Peng Chen, Fen Yang, Wenya Wang, Xiao Li, Dongling Liu, Yongxi Zhang, Guotian Yin, Fenghua Lv, Zhikun Guo, Jawahar L. Mehta, Xianwei Wang
Summary: The study found that liraglutide can reduce blood pressure and blood sugar in hypertensive mice, inhibit cardiac fibrosis, and decrease AT1R expression and ROS generation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Review
Cardiac & Cardiovascular Systems
Husam M. Salah, Jawahar L. Mehta
Summary: The differences in outcomes of COVID-19 infection between men and women may be due to variations in ACE2 activity, with men having a higher prevalence of hypertension and heart failure, leading to worse outcomes compared to women.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Letter
Cardiac & Cardiovascular Systems
Husam M. Salah, Jawahar L. Mehta
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Nishank Jain, Milind A. Phadnis, Bradley C. Martin, Jawahar L. Mehta
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Dinesh Voruganti, Pier Paolo Bassareo, Giuseppe Calcaterra, J. L. Mehta
Review
Immunology
Cesare de Gregorio, Luigi Colarusso, Giuseppe Calcaterra, Pier Paolo Bassareo, Antonio Ieni, Anna Teresa Mazzeo, Giuseppe Ferrazzo, Alberto Noto, Ioanna Koniari, Jawahar L. Mehta, Nicholas G. Kounis
Summary: In this literature review, rare side effects related to cerebral venous sinus thrombosis (CVST) after COVID-19 vaccination were investigated. The majority of cases occurred in women who received the AZD1222/Vaxzevria vaccine, with thrombi primarily located in transverse, sigmoid, and superior sagittal sinuses. Brain injury, mainly intracranial bleeding, was observed in a significant number of patients.
Article
Chemistry, Medicinal
Rajshekhar A. Kore, Ashim K. Bagchi, Kottayil Varughese, Jawahar L. Mehta
Summary: In this review, we focus on the newly studied and developed LOX-1 inhibitors that may have potential for treating diseases characterized by LOX-1 activation.
FUTURE MEDICINAL CHEMISTRY
(2022)
Editorial Material
Medicine, General & Internal
Vignesh Chidambaram, Amudha Kumar, Giuseppe Calcaterra, Jawahar L. Mehta
Article
Biochemical Research Methods
J. Curran Henson, Anna Brickell, Jin-Woo Kim, Hanna Jensen, Jawahar L. Mehta, Morten Jensen
Summary: This study evaluated the direct toxicity of PEGylated GNPs on cardiomyocytes and found a relationship between cell viability and particle size and concentration. These new findings could advance the application of gold nanoparticles in cardiovascular medicine.
IEEE TRANSACTIONS ON NANOBIOSCIENCE
(2022)
Review
Cardiac & Cardiovascular Systems
Amudha Kumar, Vignesh Chidambaram, Jawahar L. Mehta
Summary: Cardiovascular diseases (CVDs) are the leading cause of death globally, and an unhealthy diet is a major modifiable risk factor for CVD. Plant-based diets (PBDs) have been suggested to decrease the incidence of various cardiovascular diseases. This review explores the spectrum of PBDs, their mechanisms for improving cardiovascular health, challenges in dietary intervention studies, and the importance of PBDs for environmental sustainability, climate change, and animal welfare.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Akanksha Tomar, Sibasis Sahoo, Muthusankar Aathi, Shobhan Kuila, Mohd Azeem Khan, Guru Raj Rao Ravi, Jeyakanthan Jeyaraman, Jawahar L. Mehta, Kottayil I. Varughese, Arulandu Arockiasamy
Summary: This study identifies two druggable sites of lectin-like oxidized low-density lipoprotein (ox-LDL) receptor 1 (LOX-1) and shortlists small molecules targeting these sites. Experimental results show that four of the selected molecules bind to LOX-1 receptor with high affinity. The findings suggest that LOX-1 can be targeted with small molecules, providing strategies to identify novel inhibitors for attenuating ox-LDL - LOX-1 interaction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Ragul Manoharan, Rajshekhar A. Kore, Jawahar L. Mehta
Summary: New variants of COVID-19 pose challenges to treatment as they become more adept at evading the immune system. The hyperactivity of the immune system is a major obstacle in treating the disease. Mesenchymal stem cells offer a potential solution, as they have been shown to repair cells and regulate the immune system.
Article
Biochemistry & Molecular Biology
Rajshekhar A. Kore, Samir V. Jenkins, Azemat Jamshidi-Parsian, Alan J. Tackett, Robert J. Griffin, Srinivas Ayyadevara, Jawahar L. Mehta
Summary: Research has shown that mesenchymal stem cell exosomes can alleviate cardiac dysfunction in animal models of ischemia. These exosomes carry active and inactive proteins, including often-overlooked transcriptional regulators, which can influence the transcriptome and proteome of recipient cells. The study investigates the differentially modulated transcriptional factors and regulators in MSC exosome-treated ischemic mouse hearts and their potential role in modulating cardiac function. The findings provide insight into the mechanisms underlying cardiac dysfunction during ischemia and pave the way for future studies on the modulation of cardiac function by MSC exosomes.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2023)
Article
Urology & Nephrology
Adam Corken, Jerry Ware, Junqiang Dai, John M. Arthur, Susan Smyth, Clayton L. Davis, Juan Liu, Terry O. Harville, Milind A. Phadnis, Jawahar L. Mehta, Yasir Rahmatallah, Nishank Jain
Summary: The interaction between platelets and leukocytes is attenuated in CKD patients, without changes in platelet activation status. Monocyte differentiation state is altered and inflammatory markers are elevated. Platelet-derived cytokines are tightly correlated with others.
Article
Urology & Nephrology
Nishank Jain, Bradley C. Martin, Junqiang Dai, Milind A. Phadnis, Layth Al-Hindi, Theresa Shireman, S. Susan Hedayati, Rafia S. Rasu, Jawahar L. Mehta
Summary: Individuals aged >75 years are the fastest-growing population starting dialysis for end-stage kidney disease (ESKD) due to longer survival with coronary artery disease. ESKD itself increases bleeding risk, and P2Y12 inhibitor (P2Y12-I) antiplatelet medications prescribed for cardiovascular treatment can exacerbate this risk in ESKD patients. The age-specific rates of bleeding complications in dialysis patients with ESKD on P2Y12-I remain unclear, as does the effect of age on modifying the bleeding risk from P2Y12-I use in these patients.