Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression

(2011) Jeff A Klomp et al.   BMC Medical Genomics

PGC1  Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

(2011) K. Bhalla et al.   CANCER RESEARCH

The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

(2011) Jun Wu et al.   Cell Metabolism

mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

(2011) E. A. Goncharova et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

(2011) T P Cash et al.   ONCOGENE

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-β signaling

(2010) Seung-Beom Hong et al.   Molecular Cancer

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Absence of the Birt–Hogg–Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

(2010) R S Preston et al.   ONCOGENE

Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization

(2010) Seung-Beom Hong et al.   PLoS One

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Diagnostic biomarkers for renal cell carcinoma: selection using novel bioinformatics systems for microarray data analysis

(2009) Adeboye O. Osunkoya et al.   HUMAN PATHOLOGY

Renal tumour suppressor function of the Birt-Hogg-Dube syndrome gene product folliculin

(2009) V. Hudon et al.   JOURNAL OF MEDICAL GENETICS

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Interacts with the Androgen Receptor (AR) and Promotes Prostate Cancer Cell Growth by Activating the AR

(2009) Masaki Shiota et al.   MOLECULAR ENDOCRINOLOGY

The role of the Birt–Hogg–Dubé protein in mTOR activation and renal tumorigenesis

(2009) T R Hartman et al.   ONCOGENE

Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2

(2009) Y. Hasumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma

(2008) J. A. Mayr et al.   CLINICAL CANCER RESEARCH

Identification and characterization of a novel folliculin-interacting protein FNIP2

(2008) Hisashi Hasumi et al.   GENE

Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys

(2008) M. Baba et al.   JNCI-Journal of the National Cancer Institute

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

(2008) Y Takagi et al.   ONCOGENE