Granzyme M: behind enemy lines

Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets

(2015) Judy Lieberman   IMMUNOLOGICAL REVIEWS

Perforin: structure, function, and role in human immunopathology

(2015) Ilia Voskoboinik et al.   IMMUNOLOGICAL REVIEWS

Orphan granzymes find a home

(2015) Niels Bovenschen et al.   IMMUNOLOGICAL REVIEWS

NK Cell Protease Granzyme M Targets  -Tubulin and Disorganizes the Microtubule Network

(2014) N. Bovenschen et al.   JOURNAL OF IMMUNOLOGY

Granzyme M cannot induce cell death via cleavage of mouse FADD

(2013) Stefanie A. H. de Poot et al.   APOPTOSIS

Involvement of human topoisomerase II isoforms in HIV-1 reverse transcription

(2013) S. Lokeswara Balakrishna et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation

(2013) Niels Bovenschen et al.   CLINICAL IMMUNOLOGY

Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinoma

(2012) Zeyi Deng et al.   CANCER SCIENCE

Granzyme M targets host cell hnRNP K that is essential for human cytomegalovirus replication

(2012) R van Domselaar et al.   CELL DEATH AND DIFFERENTIATION

All Human Granzymes Target hnRNP K That Is Essential for Tumor Cell Viability

(2012) Robert van Domselaar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of SERPINB1 As a Physiological Inhibitor of Human Granzyme H

(2012) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Human and mouse granzyme M display divergent and species-specific substrate specificities

(2011) Stefanie A.H. de Poot et al.   BIOCHEMICAL JOURNAL

FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade

(2011) S Wang et al.   CELL DEATH AND DIFFERENTIATION

Mouse granzyme K has pro-inflammatory potential

(2011) L T Joeckel et al.   CELL DEATH AND DIFFERENTIATION

Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells

(2011) C Zhong et al.   CELL DEATH AND DIFFERENTIATION

Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice

(2011) Paul R. Hiebert et al.   EXPERIMENTAL GERONTOLOGY

Granzyme H of Cytotoxic Lymphocytes Is Required for Clearance of the Hepatitis B Virus through Cleavage of the Hepatitis B Virus X Protein

(2011) H. Tang et al.   JOURNAL OF IMMUNOLOGY

Cleavage of von Willebrand Factor by Granzyme M Destroys Its Factor VIII Binding Capacity

(2011) Martine J. Hollestelle et al.   PLoS One

Intracellular Serine Protease Inhibitor SERPINB4 Inhibits Granzyme M-Induced Cell Death

(2011) Pieter J. A. de Koning et al.   PLoS One

Characterizing the anti-tumor function of adoptively transferred NK cells in vivo

(2010) Hollie J. Pegram et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Perforin deficiency and susceptibility to cancer

(2010) A J Brennan et al.   CELL DEATH AND DIFFERENTIATION

Granzymes in cancer and immunity

(2010) S P Cullen et al.   CELL DEATH AND DIFFERENTIATION

Proteomic profiling of proteases: tools for granzyme degradomics

(2010) Robert van Domselaar et al.   Expert Review of Proteomics

Functional dissection of the granzyme family: cell death and inflammation

(2010) Desiree A. Anthony et al.   IMMUNOLOGICAL REVIEWS

Cleavage of Survivin by Granzyme M Triggers Degradation of the Survivin-X-linked Inhibitor of Apoptosis Protein (XIAP) Complex to Free Caspase Activity Leading to Cytolysis of Target Tumor Cells

(2010) Deqing Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncytotoxic Inhibition of Cytomegalovirus Replication through NK Cell Protease Granzyme M-Mediated Cleavage of Viral Phosphoprotein 71

(2010) R. van Domselaar et al.   JOURNAL OF IMMUNOLOGY

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

(2010) D. A. Anthony et al.   JOURNAL OF IMMUNOLOGY

Granzyme M: characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors

(2010) Rukhshan Khurshid et al.   MOLECULAR BIOLOGY REPORTS

Structural Basis for Proteolytic Specificity of the Human Apoptosis-Inducing Granzyme M

(2009) L. Wu et al.   JOURNAL OF IMMUNOLOGY

The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system

(2009) Pieter J.A. de Koning et al.   MOLECULAR IMMUNOLOGY

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

(2009) J. Chia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granule-associated serine proteases: granzymes might not just be killer proteases

(2009) Christopher J. Froelich et al.   TRENDS IN IMMUNOLOGY

Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity

(2008) V Romero et al.   CELL DEATH AND DIFFERENTIATION

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Comparison in the effects of IL-2, IL-12, IL-15 and IFNα on gene regulation of granzymes of human NK cell line NK-92

(2008) Bin Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing

(2008) Sean P. Cullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccinia Virus DNA Ligase Recruits Cellular Topoisomerase II to Sites of Viral Replication and Assembly

(2008) Y.-C. J. Lin et al.   JOURNAL OF VIROLOGY

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE

Non-apoptotic functions of granzymes

(2008) V. Romero et al.   TISSUE ANTIGENS