All Human Granzymes Target hnRNP K That Is Essential for Tumor Cell Viability

Orphan granzymes find a home

(2015) Niels Bovenschen et al.   IMMUNOLOGICAL REVIEWS

Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B

(2015) Inna S. Afonina et al.   IMMUNOLOGICAL REVIEWS

NK Cell Protease Granzyme M Targets  -Tubulin and Disorganizes the Microtubule Network

(2014) N. Bovenschen et al.   JOURNAL OF IMMUNOLOGY

Human and mouse granzyme M display divergent and species-specific substrate specificities

(2011) Stefanie A.H. de Poot et al.   BIOCHEMICAL JOURNAL

FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade

(2011) S Wang et al.   CELL DEATH AND DIFFERENTIATION

The substrate specificity profile of human granzyme A

(2010) Petra Van Damme et al.   BIOLOGICAL CHEMISTRY

Proteomic profiling of proteases: tools for granzyme degradomics

(2010) Robert van Domselaar et al.   Expert Review of Proteomics

The heterogeneous nuclear ribonucleoprotein K is important for Herpes simplex virus-1 propagation

(2010) Tina Schmidt et al.   FEBS LETTERS

Valosin-Containing Protein Cleavage by Granzyme K Accelerates an Endoplasmic Reticulum Stress Leading to Caspase-Independent Cytotoxicity of Target Tumor Cells

(2010) Y. Guo et al.   JOURNAL OF IMMUNOLOGY

Probing the Efficiency of Proteolytic Events by Positional Proteomics

(2010) Kim Plasman et al.   MOLECULAR & CELLULAR PROTEOMICS

Complementary positional proteomics for screening substrates of endo- and exoproteases

(2010) Petra Van Damme et al.   NATURE METHODS

Inactivation of hnRNP K by Expanded Intronic AUUCU Repeat Induces Apoptosis Via Translocation of PKCδ to Mitochondria in Spinocerebellar Ataxia 10

(2010) Misti C. White et al.   PLoS Genetics

Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer

(2009) P Barboro et al.   BRITISH JOURNAL OF CANCER

Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction

(2009) Feng-Hou Gao et al.   EXPERIMENTAL CELL RESEARCH

Heterogeneous ribonucleoprotein K is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma

(2009) Ajay Matta et al.   INTERNATIONAL JOURNAL OF CANCER

Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53

(2009) Renyuan Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Heterogeneous Nuclear Ribonucleoprotein K Represses the Production of Pro-apoptotic Bcl-xSSplice Isoform

(2009) Timothée Revil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis

(2009) G. Hua et al.   JOURNAL OF IMMUNOLOGY

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

Heterogeneous Ribonucleoprotein K and Thymidine Phosphorylase Are Independent Prognostic and Therapeutic Markers for Nasopharyngeal Carcinoma

(2008) L.-C. Chen et al.   CLINICAL CANCER RESEARCH

Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A

(2008) Niels Bovenschen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing

(2008) Sean P. Cullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication

(2008) J.-Y. Lin et al.   JOURNAL OF GENERAL VIROLOGY

Analysis of Protein Processing by N-terminal Proteomics Reveals Novel Species-specific Substrate Determinants of Granzyme B Orthologs

(2008) Petra Van Damme et al.   MOLECULAR & CELLULAR PROTEOMICS

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

(2008) Yuming Guo et al.   MOLECULAR IMMUNOLOGY

Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage

(2007) Qiang Hou et al.   MOLECULAR IMMUNOLOGY