Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

(2016) Stephanos Pavlides et al.   Aging-US

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

(2014) Nathalie M. Mazure et al.   Autophagy

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

Towards a new “stromal-based” classification system for human breast cancer prognosis and therapy

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Mediating effect of ROS on mtDNA damage and low ATP content induced by arsenic trioxide in mouse oocytes

(2011) Wenya Zhang et al.   TOXICOLOGY IN VITRO

Is Dysfunction of Caveolin-1 a Link Between Systemic Sclerosis and Breast Cancer, Opening a Window on Both Etiologies?

(2010) Niansong Qian et al.   ARCHIVES OF MEDICAL RESEARCH

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

RB-pathway disruption in breast cancer

(2010) Adam Ertel et al.   CELL CYCLE

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling

(2010) Gemma Migneco et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice

(2010) Natalia Papeta et al.   JOURNAL OF CLINICAL INVESTIGATION

Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis

(2009) Makiya Nishikawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma

(2009) Masayuki Nakao et al.   CANCER

Autophagy Is Activated by TGF-  and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells

(2009) K. Kiyono et al.   CANCER RESEARCH

Genomic Alterations in Tumor Stroma

(2009) C. Eng et al.   CANCER RESEARCH

Global Gene Expression Analysis of Reactive Stroma in Prostate Cancer

(2009) O. Dakhova et al.   CLINICAL CANCER RESEARCH

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase

(2009) Kenji Hyoudou et al.   JOURNAL OF CONTROLLED RELEASE

Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis

(2008) Francesco Del Galdo et al.   ARTHRITIS AND RHEUMATISM

SOD derivatives prevent metastatic tumor growth aggravated by tumor removal

(2008) Kenji Hyoudou et al.   CLINICAL & EXPERIMENTAL METASTASIS

Gene Expression Profiles Associated with the Presence of a Fibrotic Focus and the Growth Pattern in Lymph Node-Negative Breast Cancer

(2008) G. G. Van den Eynden et al.   CLINICAL CANCER RESEARCH

Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression

(2008) C. G. Kleer et al.   CLINICAL CANCER RESEARCH

Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer

(2008) G. E. Ayala et al.   CLINICAL CANCER RESEARCH

Caveolin-1, transforming growth factor-β receptor internalization, and the pathogenesis of systemic sclerosis

(2008) Francesco Del Galdo et al.   CURRENT OPINION IN RHEUMATOLOGY

Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis

(2008) Hitomi Nomura et al.   HUMAN PATHOLOGY

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

(2008) Wei Yin et al.   STROKE

Sustained hypoxia modulates mitochondrial DNA content in the neonatal rat brain

(2007) Heung M. Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human Skin Keloid Fibroblasts Display Bioenergetics of Cancer Cells

(2007) Annette S. Vincent et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY