Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells

Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas

(2013) Carla Minoia et al.   BRITISH JOURNAL OF HAEMATOLOGY

Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101

(2013) Yongjun Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hypoxia-induced downregulation of miR-30c promotes epithelial-mesenchymal transition in human renal cell carcinoma

(2013) Jiwei Huang et al.   CANCER SCIENCE

HIF-1  of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target

(2013) R. Ria et al.   CLINICAL CANCER RESEARCH

Gambogic acid inhibits angiogenesis through inhibiting PHD2–VHL–HIF-1α pathway

(2013) Na Lu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Bone marrow angiogenesis in myeloma and its precursor disease: a prospective clinical trial

(2013) M Bhutani et al.   LEUKEMIA

Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction

(2013) P Storti et al.   LEUKEMIA

Involvement of c-Jun N-terminal kinase in reversal of multidrug resistance of human leukemia cells in hypoxia by 5-bromotetrandrine

(2013) Wei Zhang et al.   LEUKEMIA & LYMPHOMA

New targets for the antitumor activity of gambogic acid in hematologic malignancies

(2012) Li-jing Yang et al.   ACTA PHARMACOLOGICA SINICA

Gambogic Acid is a Novel Anti-cancer Agent that Inhibits Cell Proliferation, Angiogenesis and Metastasis

(2012) Xu Wang et al.   Anti-Cancer Agents in Medicinal Chemistry

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

(2012) A. K. Azab et al.   BLOOD

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia

(2012) Jayashree Karar et al.   CANCER BIOLOGY & THERAPY

SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway

(2012) Sang-Won Hong et al.   CANCER SCIENCE

Angiopoietins as biomarker of disease activity and response to therapy in multiple myeloma

(2012) Archana Bhaskar et al.   LEUKEMIA & LYMPHOMA

Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy

(2011) Yasufumi Sato   CANCER SCIENCE

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

(2011) S K Martin et al.   LEUKEMIA

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible factors in mantle cell lymphoma: implication for an activated mTORC1→HIF-1α pathway

(2010) Pinelopi Argyriou et al.   ANNALS OF HEMATOLOGY

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells

(2010) S Colla et al.   LEUKEMIA

Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells

(2009) Tao Dai et al.   ACTA PHARMACOLOGICA SINICA

Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells

(2009) A. K. Ghosh et al.   BLOOD

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells

(2008) Salida Mirzoeva et al.   MOLECULAR CARCINOGENESIS

Histological expression of angiogenic factors: VEGF, PDGFRα, and HIF-1α in Hodgkin lymphoma

(2008) Freda H. Passam et al.   PATHOLOGY RESEARCH AND PRACTICE

Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum

(2008) Astrid E. Greijer et al.   VIRCHOWS ARCHIV