SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway

Gensenoside Rg3 Inhibits Hypoxia-induced VEGF Expression in Human Cancer Cells

(2011) Qing-Jiang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma

(2011) Zuo-Lin Xiang et al.   CLINICAL CANCER RESEARCH

Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma

(2011) Qian Zhou et al.   Future Oncology

Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder

(2011) Chih-Hao Sun et al.   HISTOPATHOLOGY

Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells

(2011) Qiong Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cytotoxic Triterpenoid Saponins from the Rhizomes ofAnemone taipaiensis

(2011) Xiao-Yang Wang et al.   PLANTA MEDICA

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

(2011) Pin-Shern Chen et al.   PLoS One

Intestinal Metabolite Compound K of Ginseng Saponin Potently Attenuates Metastatic Growth of Hepatocellular Carcinoma by Augmenting Apoptosis via a Bid-Mediated Mitochondrial Pathway

(2010) Gang Song et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

(2010) Masayoshi Arai et al.   Journal of Natural Medicines

Steroidal Saponins from the Rhizomes ofDioscorea bulbiferaand Their Cytotoxic Activity

(2010) Hai Liu et al.   PLANTA MEDICA

Novel treatments for hepatocellular cancer

(2009) S.H. Kerr et al.   CANCER LETTERS

Pathogenesis of hepatocellular carcinoma and molecular therapies

(2009) Beatriz Mínguez et al.   CURRENT OPINION IN GASTROENTEROLOGY

The role of mTOR in the management of solid tumors: An overview

(2008) Alex S. Strimpakos et al.   CANCER TREATMENT REVIEWS

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

Diagnosis and Treatment of Hepatocellular Carcinoma

(2008) Hashem B. El-Serag et al.   GASTROENTEROLOGY

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY