Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells
出版年份 2014 全文链接
标题
Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells
作者
关键词
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出版物
CANCER SCIENCE
Volume 105, Issue 8, Pages 1063-1070
出版商
Wiley
发表日期
2014-05-29
DOI
10.1111/cas.12458
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas
- (2013) Carla Minoia et al. BRITISH JOURNAL OF HAEMATOLOGY
- Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101
- (2013) Yongjun Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Hypoxia-induced downregulation of miR-30c promotes epithelial-mesenchymal transition in human renal cell carcinoma
- (2013) Jiwei Huang et al. CANCER SCIENCE
- HIF-1 of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target
- (2013) R. Ria et al. CLINICAL CANCER RESEARCH
- Gambogic acid inhibits angiogenesis through inhibiting PHD2–VHL–HIF-1α pathway
- (2013) Na Lu et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Bone marrow angiogenesis in myeloma and its precursor disease: a prospective clinical trial
- (2013) M Bhutani et al. LEUKEMIA
- Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction
- (2013) P Storti et al. LEUKEMIA
- Involvement of c-Jun N-terminal kinase in reversal of multidrug resistance of human leukemia cells in hypoxia by 5-bromotetrandrine
- (2013) Wei Zhang et al. LEUKEMIA & LYMPHOMA
- New targets for the antitumor activity of gambogic acid in hematologic malignancies
- (2012) Li-jing Yang et al. ACTA PHARMACOLOGICA SINICA
- Gambogic Acid is a Novel Anti-cancer Agent that Inhibits Cell Proliferation, Angiogenesis and Metastasis
- (2012) Xu Wang et al. Anti-Cancer Agents in Medicinal Chemistry
- Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
- (2012) A. K. Azab et al. BLOOD
- Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia
- (2012) Jayashree Karar et al. CANCER BIOLOGY & THERAPY
- SB365 inhibits angiogenesis and induces apoptosis of hepatocellular carcinoma through modulation of PI3K/Akt/mTOR signaling pathway
- (2012) Sang-Won Hong et al. CANCER SCIENCE
- Angiopoietins as biomarker of disease activity and response to therapy in multiple myeloma
- (2012) Archana Bhaskar et al. LEUKEMIA & LYMPHOMA
- Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy
- (2011) Yasufumi Sato CANCER SCIENCE
- The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma
- (2011) S K Martin et al. LEUKEMIA
- Multiple Myeloma
- (2011) Antonio Palumbo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Hypoxia-inducible factors in mantle cell lymphoma: implication for an activated mTORC1→HIF-1α pathway
- (2010) Pinelopi Argyriou et al. ANNALS OF HEMATOLOGY
- Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
- (2010) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Low bone marrow oxygen tension and hypoxia-inducible factor-1α overexpression characterize patients with multiple myeloma: role on the transcriptional and proangiogenic profiles of CD138+ cells
- (2010) S Colla et al. LEUKEMIA
- Hypoxia confers protection against apoptosis via the PI3K/Akt pathway in endothelial progenitor cells
- (2009) Tao Dai et al. ACTA PHARMACOLOGICA SINICA
- Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
- (2009) A. K. Ghosh et al. BLOOD
- Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
- (2009) G L Semenza ONCOGENE
- Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells
- (2008) Salida Mirzoeva et al. MOLECULAR CARCINOGENESIS
- Histological expression of angiogenic factors: VEGF, PDGFRα, and HIF-1α in Hodgkin lymphoma
- (2008) Freda H. Passam et al. PATHOLOGY RESEARCH AND PRACTICE
- Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum
- (2008) Astrid E. Greijer et al. VIRCHOWS ARCHIV
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