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Chemistry, Medicinal
Rungtip Soi-ampornkul, Ei Ei Phyo Myint, Wipawan Thangnipon, Nutnicha Tantarungsee, Chalermchai Mitrpant, Patoomratana Tuchinda, Saksit Nobsathian, Chinnavuth Vatanashevanopakorn
Summary: This study investigated the antioxidative and anti-apoptotic properties of N-trans-feruloyltyramine (NTF) extracted from the stems of Polyalthia suberosa in human neuroblastoma cell line SK-N-SH. The results showed that NTF significantly reduced intracellular ROS levels, decreased H2O2 toxicity, and reversed the changes in apoptosis-related protein expression induced by H2O2.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Barbara Kreczmer, Barbara Dyba, Anna Barbasz, Elzbieta Rudolphi-Szydlo
Summary: Quercetin, a polyphenolic compound, exhibits potential anticancer, antiinflammatory, and antioxidant properties, but may also have pro-oxidative and cytotoxic effects. Research suggests that quercetin's action in cells may be primarily through altering the stiffness/elasticity of cell membranes, impacting cellular processes associated with membrane functions.
Article
Pharmacology & Pharmacy
Matthias Apweiler, Jana Streyczek, Soraya Wilke Saliba, Johannes Ditrich, Eduardo Munoz, Bernd L. Fiebich
Summary: The study showed that AM404 and acetaminophen can inhibit IL-1β-induced PGE(2) release, potentially providing a therapeutic option for neuroinflammation and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wang
Summary: EV71 infection leads to changes in mitochondrial morphology and dynamics in human neuroblastoma cells, resulting in mitochondrial dysfunction that may contribute to nervous system dysfunction.
Article
Biochemistry & Molecular Biology
Vamsi Krishna Kommalapati, Dinesh Kumar, Anjana Devi Tangutur
Summary: Neuroblastoma is a common childhood cancer with poor prognosis, and Quisinostat/JNJ-26481585 has been shown to induce differentiation in SK-N-SH cells while autophagy plays a crucial role in this process.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biology
Seksiri Arttamangkul, Emily J. Platt, James Carroll, David Farrens
Summary: The study found that single cholinergic neurons in the mouse striatum express both MORs and DORs, and through fluorescent labeling and selective activation experiments, it was revealed their mechanisms in regulating cellular electrical activity. The results indicate that the two receptors function independently.
Article
Environmental Sciences
Qian Zhang, Jingjing Zhang, Bailing Liu, Jingli Wei
Summary: Licochalcone (Lic) has been found to have inhibitory effects on neuroblastoma (NB), and it exerts its effects through regulating the trxR1/Nrf2/STAT6 signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nan Zhang, Li Zhao, Yan Su, Xiaoliang Liu, Feilong Zhang, Yiwen Gao
Summary: The study revealed that Syringin could protect against A beta-induced neurotoxicity by regulating the miR-124-3p/BID pathway, providing a potential mechanism for Syringin to treat AD.
NEUROCHEMICAL RESEARCH
(2021)
Article
Plant Sciences
Carla Russo, Kieron D. Edwards, Gemma Margetts, Sotirios Kleidonas, Nawel S. Zaibi, John C. Clapham, Mohamed S. Zaibi
Summary: Chamomile showed stronger anti-inflammatory effects compared to sage in both cell lines, with a strong reduction in both populations. Both extracts reduced ACM-induced inflammation effect, suggesting they could be used as possible preventive treatment for late-life cognitive impairment related to chronic inflammation. Further studies are needed to explore their effects on other chronic inflammation-related diseases, such as type 2 diabetes or rheumatoid arthritis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jay P. McLaughlin, Ramanjaneyulu Rayala, Ashley J. Bunnell, Mukund P. Tantak, Shainnel O. Eans, Khadija Nefzi, Michelle L. Ganno, Colette T. Dooley, Adel Nefzi
Summary: The synthesis of bis-cyclic guanidine heterocyclic peptidomimetics has shown potential as a new class of analgesics with multifunctional opioid receptor activity, offering reduced side effects and minimizing the risk of respiratory depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Natalia V. Naryzhnaya, Alexander V. Mukhomedzyanov, Maria Sirotina, Leonid N. Maslov, Boris K. Kurbatov, Alexander S. Gorbunov, Mikhail Kilin, Artur Kan, Andrey V. Krylatov, Yuri K. Podoksenov, Sergey V. Logvinov
Summary: Analysis of data and studies shows that activation of peripheral & delta;(2)-opioid receptor (& delta;(2)-OR) can increase cardiac tolerance to reperfusion, and this receptor is found in cardiomyocytes. Endogenous opioids do not regulate cardiac resistance to reperfusion. The infarct-limiting effect of & delta;(2)-OR agonist deltorphin II depends on activation of several protein kinases, including PKC & delta;, ERK1/2, PI3K, and PKG. Hypothetical end-effectors of the cardioprotective effect of deltorphin II are sarcolemmal K-ATP channels and the MPT pore.
Article
Biochemistry & Molecular Biology
Zijie Ye, Danyang Chen, Ruilin Zheng, Haiyang Chen, Tiantian Xu, Changbing Wang, Shibo Zhu, Xiaofeng Gao, Jin Zhang, Dian Li, Yueyin Pang, Bing Zhu, Yinghua Li, Wei Jia
Summary: Neuroblastoma is a solid tumor with high mortality rates in children, and curcumin has shown anticancer properties in treating these tumors. Curcumin inhibits cell proliferation and migration, induces apoptosis through cell cycle arrest and caspase-3 activation, and promotes ROS overproduction and apoptosis through p53 and Bcl-2 pathways in NB cells.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Neurosciences
Rafael A. Cazuza, Ana Luisa F. Arantes, Olga Pol, Christie R. A. Leite-Panissi
Summary: The study shows that activation of the HO-CO pathway promotes anti-allodynic effects and reduces pain aversiveness caused by peripheral inflammation by increasing the expression of MOR and DOR activated by HO-1 in the dorsal hippocampus.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Anley Teferra Kiddane, Vikash Chandra Roy, Min-Jae Kang, Maheshkumar Prakash Patil, Byung-Soo Chun, Gun-Do Kim
Summary: The phospholipid extract from S. niphonius' bone exhibited anticancer activity on neuroblastoma SK-N-SH cells without significant toxicity on normal cells. The mechanism involved the regulation of signaling proteins and gene expression to induce apoptosis.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Hiroko P. Indo, Hiromu Ito, Keiichi Nakagawa, Luksana Chaiswing, Hideyuki J. Majima
Summary: This study found that electron and X-ray irradiation in human neuroblastoma cells leads to increase in mitochondrial ROS production, lipid peroxidation, HSP47, myristoylation, and farnesylation levels. HSP47 plays an important role in mitochondria and influences ROS production.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)
