Biased signalling and allosteric machines: new vistas and challenges for drug discovery

Impact of species variability and ‘probe-dependence’ on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor

(2010) S Suratman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

(2010) C. Koole et al.   MOLECULAR PHARMACOLOGY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

On the fitting of binding data when receptor dimerization is suspected

(2008) J Giraldo   BRITISH JOURNAL OF PHARMACOLOGY

The Relative Activity of "Function Sparing" HIV-1 Entry Inhibitors on Viral Entry and CCR5 Internalization: Is Allosteric Functional Selectivity a Valuable Therapeutic Property?

(2008) V. M. Muniz-Medina et al.   MOLECULAR PHARMACOLOGY

How and why do GPCRs dimerize?

(2008) Vsevolod V. Gurevich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

G-protein-coupled receptor heteromers: function and ligand pharmacology

(2007) R Franco et al.   BRITISH JOURNAL OF PHARMACOLOGY

A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization

(2007) G Milligan   BRITISH JOURNAL OF PHARMACOLOGY