Review
Anesthesiology
Annina B. B. Schmid, Brigitte Tampin, Ralf Baron, Nanna B. B. Finnerup, Per Hansson, Aki Hietaharju, Kika Konstantinou, Chung-Wei Christine Lin, John Markman, Christine Price, Blair H. H. Smith, Helen Slater
Summary: This article presents the outcomes of a working group commissioned by the Neuropathic Pain Special Interest Group (NeuPSIG) of the International Association for the Study of Pain (IASP), which aimed to revise the use of terminology for classifying spine-related leg pain and propose a way forward on the identification of neuropathic pain in this context.
Review
Medicine, General & Internal
Pietro Emiliano Doneddu, Umberto Pensato, Alessandra Iorfida, Claudia Alberti, Eduardo Nobile-Orazio, Andrea Fabbri, Antonio Voza
Summary: Neuropathic pain is increasingly encountered in the emergency department, accounting for approximately 20% of patients with pain. Understanding its physiology and clinical presentations is crucial for optimal treatment. Diagnosing can be challenging, but emphasis should be placed on comprehensive medical history and examination. Collaboration among different specialties can contribute to evidence-based guidelines for emergency medicine.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Dan Ziegler, Solomon Tesfaye, Vincenza Spallone, Irina Gurieva, Juma Al Kaabi, Boris Mankovsky, Emil Martinka, Gabriela Radulian, Khue Thy Nguyen, Alin O. Stirban, Tsvetalina Tankova, Tamas Varkonyi, Roy Freeman, Peter Kempler, Andrew J. M. Boulton
Summary: Diabetic sensorimotor polyneuropathy (DSPN) is a common condition in diabetes patients, affecting around one third of them. It can lead to various complications and has significant impact on patients' lives. However, it is often inadequately diagnosed and treated. This article provides expert consensus recommendations and algorithms for the screening, diagnosis, and treatment of DSPN, aiming to improve patients' quality of life.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Medical Laboratory Technology
Makoto Kurano, Masahiko Sumitani, Yoshiyuki Akiyama, Masaki Yamada, Daiki Fujimura, Satoshi Yamaki, Kuniyuki Kano, Junken Aoki, Kentaro Hayakawa, Takuya Takahashi, Takashi Hirai, Atsushi Okawa, Haruki Kume, Toru Ogata, Sakae Tanaka, Hirotaka Chikuda, Yutaka Yatomi
Summary: This study found that measuring LPC concentrations in the cerebrospinal fluid is a reliable method for differentiating between neuropathic pain caused by SCS and neuropathic pain caused by other diseases. It has potential clinical value in surgical decision-making.
CLINICA CHIMICA ACTA
(2023)
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Anatomy & Morphology
Niamh A. Moloney, Dorine Lenoir
Summary: Neuropathic cancer pain is a common condition, affecting up to 58% of patients with persistent pain after cancer treatment. It can develop from malignancy, surgical nerve tissue damage, exposure to radiation, and neurotoxic agents. Poor recognition and assessment of pain are barriers to adequate treatment. Understanding the presence of neuropathic cancer pain is important for effective pain management, as it requires specific treatment targeting neuropathic mechanisms.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Review
Plant Sciences
Geovanna N. Quinonez-Bastidas, Andres Navarrete
Summary: Most studies on Mexican medicinal plants have focused on inflammatory experimental models for testing their anti-pain properties, with results showing lack of adverse effects and safety for consumption. However, there is still no convincing evidence on the possible mechanisms of action involved in the anti-pain properties of Mexican plants, highlighting the need for further isolation and pharmacological characterization of their compounds for future preclinical studies.
Article
Pharmacology & Pharmacy
Bojun Xiong, Guilin Jin, Ying Xu, Wenbing You, Yufei Luo, Menghan Fang, Bing Chen, Huihui Huang, Jian Yang, Xu Lin, Changxi Yu
Summary: Koumine has been identified as a potential positive allosteric modulator of TSPO, showing promising pharmacological characteristics in the treatment of inflammatory and neuropathic pain. The in vitro and in vivo experiments demonstrate its high affinity for TSPO and its ability to enhance the therapeutic effects of TSPO agonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Morena Shkodra, Cinzia Brunelli, Ernesto Zecca, Fabio Formaglio, Paola Bracchi, Silvia Lo Dico, Mariangela Caputo, Stein Kaasa, Augusto Caraceni
Summary: The study highlights the lack of standardized clinical diagnosis for Neuropathic cancer pain (NcP), leading to disagreements in classification among clinicians. Discordance was particularly high for specific pain syndromes.
Article
Neurosciences
Tabea M. Dyong, Burkhard Gess, Christina Dumke, Roman Rolke, Maike F. Dohrn
Summary: Myopathies, specifically muscle pain, are often overlooked rare diseases with limited treatment options. This study retrospectively analyzed the response to carbamazepine treatment for muscle pain in 54 individuals with various myopathies. The results showed that carbamazepine significantly reduced pain levels but was associated with side effects and discontinuation in some patients.
Review
Medicine, General & Internal
Ahmad Khoshal Khorami, Crystian B. Oliveira, Christopher G. Maher, Patrick J. E. Bindels, Gustavo C. Machado, Rafael Z. Pinto, Bart W. Koes, Alessandro Chiarotto
Summary: This study systematically reviewed international clinical practice guidelines on managing patients with lumbosacral radicular pain (LRP), identifying consistent diagnostic and therapeutic recommendations. It emphasized key diagnostic tests and recommended treatment options, providing important guidance for healthcare professionals in managing LRP patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shimrit Heiliczer, Asaf Wilensky, Tal Gaver, Olga Georgiev, Sharleen Hamad, Alina Nemirovski, Rivka Hadar, Yair Sharav, Doron J. Aframian, Joseph Tam, Yaron Haviv
Summary: The endocannabinoid system plays a role in pain processes, and specific salivary endocannabinoids may serve as biomarkers for chronic orofacial pain (OFP). Salivary samples showed signature eCB profiles for major OFP disorders, providing potential for more accurate diagnoses and management of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Pottathil Shinu, Mohamed A. Morsy, Anroop B. Nair, Abdulaziz K. Al Mouslem, Katharigatta N. Venugopala, Manoj Goyal, Monika Bansal, Shery Jacob, Pran Kishore Deb
Summary: Neuropathic pain affects over one million people worldwide, and current treatment options only provide symptomatic relief with severe side effects and tolerance. Recent research focuses on developing more effective interventions for neuropathic pain. This review provides insights into interventional strategies and the current state of pain research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Achille Iolascon, Paola Bianchi, Immacolata Andolfo, Roberta Russo, Wilma Barcellini, Elisa Fermo, Gergely Toldi, Stefano Ghirardello, Davis Rees, Richard Van Wijk, Antonis Kattamis, Patrick G. Gallagher, Noemi Roy, Ali Taher, Razan Mohty, Andreas Kulozik, Lucia De Franceschi, Antonella Gambale, Mariane De Montalembert, Gian Luca Forni, Cornelis L. Harteveld, Josef Prchal
Summary: Methemoglobinemia can be caused by inherited or acquired factors, with genetic variants playing a significant role in the inherited cases. Through a systematic literature search, recommendations were formulated for clinical management and treatment, reaching a final consensus of over 75% agreement by the expert panel.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Khaled M. Abdelrahman, Kevin V. Hackshaw
Summary: Neuropathic pain affects a significant portion of the population and is often treated ineffectively, leading patients to turn to nonpharmacologic treatments such as nutritional supplements. While patients commonly use vitamins, minerals, and herbal remedies for pain relief, there is limited evidence on the efficacy and mechanisms of these supplements in neuropathic pain, necessitating further exploration through large randomized controlled trials.
