Editorial Material
Microbiology
Richard S. Bradbury, Sarah G. H. Sapp, Idzi Potters, Blaine A. Mathison, John Frean, Abhishek Mewara, Harsha Sheorey, Francesca Tamarozzi, Marc Roger Couturier, Peter Chiodini, Bobbi Pritt
Summary: Advances in laboratory techniques have transformed parasitology diagnostics, with rapid antigen detection tests and next-generation amplification and sequencing methods greatly improving detection capabilities. However, overreliance on nonmicroscopy-based methods has resulted in a loss of morphology expertise, negatively impacting patient care, public health, and epidemiology.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Astronomy & Astrophysics
Tao Chen, C. Y. Xiao, Aigen Li, C. T. Zhou
Summary: The study reveals the presence of silicon carbide (SiC) dust in the interstellar medium, but the lack of the 11.3 mu m absorption feature of SiC dust remains a mystery. The research suggests that although SiC dust could be oxidized, the destruction rate may be considerably smaller than the injection rate from carbon stars. Possible explanations include the overestimation of the stellar injection rate of SiC and/or the smaller size of SiC dust.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Economics
Steven Stern
Summary: This work extends the existing first-mover models in the context of children deciding where to live and its impact on informal care to parents. The authors propose a model that incorporates multiple children and introduces uncertainty regarding the behavior of younger siblings. The inclusion of uncertainty significantly alters the predictions of the model, with a majority of oldest children willing to give up their first-mover advantage to a social planner once private information is considered.
JOURNAL OF HUMAN RESOURCES
(2023)
Editorial Material
Psychiatry
Lynn E. DeLisi
Summary: Peer review is a crucial tool for science and scholarly publishing, but it is currently facing a crisis and requires renewed attention and time allocation.
PSYCHIATRY RESEARCH
(2022)
Review
Astronomy & Astrophysics
A. Scott Denning
Summary: Carbon, as one of the most abundant substances in the universe, plays a vital role in biochemistry. Complex interactions between carbon and climate have stabilized the Earth system. While carbon sinks in both land and oceans help slow the increase of CO2 and global warming, they are at risk of weakening or reversing with climate warming and emission reductions.
ANNUAL REVIEW OF EARTH AND PLANETARY SCIENCES
(2022)
Article
Management
Steve Kempster, Doris Schedlitzki, Gareth Edwards
Summary: This article problematizes the assumption of follower in leadership studies and explores the implications of the absence of identifications with followership on leadership assumptions. By drawing on personal experiences and conversations with executive MBA students, the authors suggest a reconsideration of leadership dynamics and a shift towards social media for understanding the concept of followership.
Article
Business, Finance
Maryam Farboodi, Adrien Matray, Laura Veldkamp, Venky Venkateswaran
Summary: As the finance industry transitions into a data-driven sector, it is crucial to measure the amount of data investors possess regarding different assets. Utilizing a structural model, we have developed a cross-sectional measure that differs from price informativeness. Furthermore, our measure demonstrates a new finding: there is an increasing abundance of data concerning large high-growth firms compared to other companies. Our structural model provides an explanation for this data divergence, attributing it to the increasing value of data for major high-growth firms as they expand and experience growth.
REVIEW OF FINANCIAL STUDIES
(2022)
Article
Surgery
N. G. Mowbray, L. Hurt, A. Powell-Chandler, N. Reeves, S. Chandler, E. Walters, J. Cornish
Summary: The COVID-19 lockdown in the UK resulted in a decreased incidence of acute appendicitis and a significant shift in treatment approaches, with increased used of CT scans, antibiotic-only treatment, and a decrease in laparoscopic appendicectomy rates.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2021)
Article
Biodiversity Conservation
Andrew J. Loveridge, Lara L. Sousa, Samuel Cushman, Zaneta Kaszta, David W. Macdonald
Summary: This study aims to predict the landscape connectivity and population size of African lions and assess the conservation of the species. The results show a significant decline in lion population and connectivity over the past five decades, with the Western and Central regions experiencing the most severe decline. The research emphasizes the importance of protecting existing connections to prevent further fragmentation and loss of genetic diversity.
DIVERSITY AND DISTRIBUTIONS
(2022)
Article
Astronomy & Astrophysics
Timo Reinhold, Alexander Shapiro, Veronika Witzke, Nina-E Nemec, Emre Isik, Sami K. Solanki
Summary: This study investigates the lack of solar-like stars with known near-solar rotation periods, attributing it to the difficulty of detecting periods due to the complexity and noise levels in photometric time series. The detectability is found to be influenced by the type of activity on the stellar surface and the level of photometric noise, complicating period detection and explaining the shortage of solar-like stars with known near-solar rotation periods. These findings suggest that the majority of solar-like stars with near-solar rotation periods remain undetected, prompting the use of new techniques to recover more rotation periods of near-solar rotators.
ASTROPHYSICAL JOURNAL LETTERS
(2021)
Article
Management
Ettore Settanni, Reinout Heijungs, Jagjit Singh Srai
Summary: This paper provides a unified methodological view of semi-quantitative problem structuring and modelling (SPSM), comparing and contrasting different techniques and highlighting overlaps and inconsistencies between them. The study emphasizes the importance of critically applying key analytical principles and leveraging human-computer interaction in SPSM research.
JOURNAL OF THE OPERATIONAL RESEARCH SOCIETY
(2023)
Article
Communication
Rebekah Tromble
Summary: The essay argues that the restrictions imposed by social media companies on academic researchers post the 2018 Facebook-Cambridge Analytica scandal have not significantly changed the underlying relationship between researchers, platforms, and digital data. It points out that researchers often overlooked rigor, ethics, and societal value in their data collection and analysis processes even when data seemed plentiful during the API era. The author suggests that digital researchers should critically examine and reflect on their past approaches to data collection and analysis to improve future research methods.
SOCIAL MEDIA + SOCIETY
(2021)
Letter
Gastroenterology & Hepatology
Francesco Valitutti, Riccardo Troncone, Pasquale Pisano, Carolina Ciacci
Summary: The Covid-19 pandemic has put immense pressure on national health systems worldwide, leading to delays in diagnosis and treatment of various diseases, and causing a potential increase in undiagnosed and untreated cases due to fear of contracting the virus and reduced access to medical care.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Economics
Xiaojia Bao, Sebastian Galiani, Cheryl Xiaoning Long, Kai Li
Summary: In the past 40 years, there has been a significant number of abandoned or abducted children in China. The implementation of the one-child policy is believed to have influenced the changes in child abandonment and abduction. The cultural preference for sons has resulted in gender-based patterns, with more girls being abandoned and more boys being abducted. Empirical evidence shows that stricter implementation of the one-child policy leads to increased local child abandonment and abduction in neighboring regions. Additionally, a stronger son-preference bias intensifies these effects. However, the frequency of child abandonment and abduction has decreased after the relaxation of the one-child policy since 2002. This paper provides empirical evidence on the unintended consequences of the one-child policy regarding missing children in China.
JOURNAL OF ECONOMIC BEHAVIOR & ORGANIZATION
(2023)
Article
Economics
Eliza Forsythe, Lisa B. Kahn, Fabian Lange, David Wiczer
Summary: This study shows that despite the massive job losses caused by the COVID pandemic, the labor market remained tight throughout the crisis and largely recovered by spring 2022. Contrary to predictions of dramatic and permanent changes in the way we work, there is surprisingly little evidence of excess reallocation, with employment mainly shifting away from low-skilled service jobs.
Article
Biochemistry & Molecular Biology
Ayami Matsushima, Hirokazu Nishimura, Yutaka Matsuyama, Xiaohui Liu, Tommaso Costa, Yasuyuki Shimohigashi
Article
Multidisciplinary Sciences
Dean P. Staus, Ryan T. Strachan, Aashish Manglik, Biswaranjan Pani, Alem W. Kahsai, Tae Hun Kim, Laura M. Wingler, Seungkirl Ahn, Arnab Chatterjee, Ali Masoudi, Andrew C. Kruse, Els Pardon, Jan Steyaert, William I. Weis, R. Scott Prosser, Brian K. Kobilka, Tommaso Costa, Robert J. Lefkowitz
Article
Biochemistry & Molecular Biology
Federica Castriconi, Marco Paolino, Alessandro Donati, Germano Giuliani, Maurizio Anzini, Laura Mennuni, Chiara Sabatini, Marco Lanza, Gianfranco Caselli, Francesco Makovec, Maria Sbraccia, Paola Molinari, Tommaso Costa, Andrea Cappelli
Article
Biochemistry & Molecular Biology
Shogo Inamine, Hirokazu Nishimura, Jinglan Li, Kaname Isozaki, Ayami Matsushima, Tommaso Costa, Yasuyuki Shimohigashi
BIOORGANIC & MEDICINAL CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
D. Malfacini, C. Ambrosio, M. C. Gro', M. Sbraccia, C. Trapella, R. Guerrini, M. Bonora, P. Pinton, T. Costa, G. Calo
Article
Multidisciplinary Sciences
H. Ongun Onaran, Caterina Ambrosio, Ozlem Ugur, Erzsebet Madaras Koncz, Maria Cristina Gro, Vanessa Vezzi, Sudarshan Rajagopal, Tommaso Costa
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
H. Ongun Onaran, Tommaso Costa
Summary: This review discusses the theoretical and experimental foundations for assessing agonism in GPCRs, emphasizing the importance of separating efficacy from affinity in understanding agonism and identifying ligands with true bias of efficacy for unraveling the conformational space that determines the complex functional chemistry of GPCRs.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Karim Nagi, H. Ongun Onaran
Summary: GPCRs are the largest family of approved therapeutic targets, with ligands stimulating these receptors often causing undesired side effects. Biased agonism offers potential for improving therapeutic responses, but the identification and quantification of biased agonists remain challenging.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Daisuke Asai, Naoko Inoue, Makiko Sugiyama, Tsugumi Fujita, Yutaka Matsuyama, Xiaohui Liu, Ayami Matsushima, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi
Summary: This study verifies the importance of the position of benzene hydrogen atoms in activating the receptor, finding that benzene-hydrogen atoms at the ortho and meta positions, rather than the para position, play a crucial role in CH/pi interaction.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Peter Kolb, Terry Kenakin, Stephen P. H. Alexander, Marcel Bermudez, Laura M. Bohn, Christian S. Breinholt, Michel Bouvier, Stephen J. Hill, Evi Kostenis, Kirill A. Martemyanov, Rick R. Neubig, H. Ongun Onaran, Sudarshan Rajagopal, Bryan L. Roth, Jana Selent, Arun K. Shukla, Martha E. Sommer, David E. Gloriam
Summary: GPCRs regulate various physiological processes and their effects depend on the pairing of a receptor and a ligand. Ligands that induce biased signalling can lead to better drug effects and fewer side effects. However, ligand bias is complex, making it necessary to develop guidelines for designing and reporting biased signalling experiments.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Biswaranjan Pani, Seungkirl Ahn, Paula K. Rambarat, Shashank Vege, Alem W. Kahsai, Andrew Liu, Bruno N. Valan, Dean P. Staus, Tommaso Costa, Robert J. Lefkowitz
Summary: Carvedilol is a first-choice agent for heart failure treatment with unique pharmacological properties, and compound-6 (cmpd-6) displays exclusive positive cooperativity with carvedilol among other fi-blockers. This cooperative effect enhances the binding affinity of carvedilol for the fi2-adrenergic receptor, potentially improving the efficacy of biased beta blockers and other GPCR therapeutics.
MOLECULAR PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Anna Rizzi, Maria Camilla Cerlesi, Chiara Ruzza, Davide Malfacini, Federica Ferrari, Sara Bianco, Tommaso Costa, Remo Guerrini, Claudio Trapella, Girolamo Calo
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2016)
Article
Pharmacology & Pharmacy
R. Lattanzi, C. Congiu, V. Onnis, A. Deplano, S. Salvadori, V. Marconi, D. Maftei, A. Francioso, C. Ambrosio, I. Casella, T. Costa, G. Caltabiano, M. T. Matsoukas, G. Balboni, L. Negri
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
(2015)
