Pathway-selective antagonism of proteinase activated receptor 2

The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease

(2013) M D Hollenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

(2013) Junxian Lim et al.   FASEB JOURNAL

Toward Drugs for Protease-Activated Receptor 2 (PAR2)

(2013) Mei-Kwan Yau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells

(2012) Christina L. Hirota et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lanthanide Labeling of a Potent Protease Activated Receptor-2 Agonist for Time-Resolved Fluorescence Analysis

(2012) Justin Hoffman et al.   BIOCONJUGATE CHEMISTRY

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

(2012) Rink-Jan Lohman et al.   FASEB JOURNAL

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2

(2012) Zhi-Jiang Huang et al.   PAIN

 -Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway

(2012) H. L. Nichols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Alternate Perspective on the Roles of TIMPs and MMPs in Pathology

(2011) Craig S. Moore et al.   AMERICAN JOURNAL OF PATHOLOGY

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)

(2011) JY Suen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biased signalling and allosteric machines: new vistas and challenges for drug discovery

(2011) Terry P Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Tissue factor–protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

(2011) Leylla Badeanlou et al.   NATURE MEDICINE

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

(2011) Y. Chen et al.   NEUROSCIENCE

Structure, function and pathophysiology of protease activated receptors

(2011) Mark N. Adams et al.   PHARMACOLOGY & THERAPEUTICS

Structural insights into adrenergic receptor function and pharmacology

(2011) Brian K. Kobilka   TRENDS IN PHARMACOLOGICAL SCIENCES

Mast cell proteases: multifaceted regulators of inflammatory disease

(2010) G. Pejler et al.   BLOOD

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protein targets of inflammatory serine proteases and cardiovascular disease

(2010) Ram Sharony et al.   Journal of Inflammation-London

Novel Agonists and Antagonists for Human Protease Activated Receptor 2

(2010) Grant D. Barry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Serine proteases of the human immune system in health and disease

(2010) Kirstin M. Heutinck et al.   MOLECULAR IMMUNOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Profiling Gene Expression Induced by Protease-Activated Receptor 2 (PAR2) Activation in Human Kidney Cells

(2010) Jacky Y. Suen et al.   PLoS One

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Proteases as Targets for Drug Development

(2009) Mare Cudic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2

(2009) Silvia Amadesi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Distinct conformational changes in  -arrestin report biased agonism at seven-transmembrane receptors

(2008) A. K. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New G-protein-coupled receptor crystal structures: insights and limitations

(2008) B KOBILKA et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice

(2006) Atsufumi Kawabata et al.   BRITISH JOURNAL OF PHARMACOLOGY