Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

Toward Drugs for Protease-Activated Receptor 2 (PAR2)

(2013) Mei-Kwan Yau et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR2) is involved in vascular function

(2012) M Bucci et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats

(2012) A. Iyer et al.   DIABETES

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

(2012) Rink-Jan Lohman et al.   FASEB JOURNAL

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

(2012) Junxian Lim et al.   FASEB JOURNAL

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)

(2011) JY Suen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tryptase/Protease-Activated Receptor 2 Interactions Induce Selective Mitogen-Activated Protein Kinase Signaling and Collagen Synthesis by Cardiac Fibroblasts

(2011) Jennifer L. McLarty et al.   HYPERTENSION

Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)

(2011) Rithwik Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue factor–protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation

(2011) Leylla Badeanlou et al.   NATURE MEDICINE

Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport

(2011) Kazuaki Ohtsubo et al.   NATURE MEDICINE

Structure, function and pathophysiology of protease activated receptors

(2011) Mark N. Adams et al.   PHARMACOLOGY & THERAPEUTICS

The Role of Palmitoylation in Signalling, Cellular Trafficking and Plasma Membrane Localization of Protease-Activated Receptor-2

(2011) Mark N. Adams et al.   PLoS One

Protease-Activated Receptor 2 Deficiency Reduces Cardiac Ischemia/Reperfusion Injury

(2010) Silvio Antoniak et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2

(2010) Ping Wang et al.   BMC BIOCHEMISTRY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

High-carbohydrate, High-fat Diet–induced Metabolic Syndrome and Cardiovascular Remodeling in Rats

(2010) Sunil K. Panchal et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Cathepsins in Human Obesity: Changes in Energy Balance Predominantly Affect Cathepsin S in Adipose Tissue and in Circulation

(2010) Nadia Naour et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel Agonists and Antagonists for Human Protease Activated Receptor 2

(2010) Grant D. Barry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Inflammatory lipid mediators in adipocyte function and obesity

(2010) Abishek Iyer et al.   Nature Reviews Endocrinology

Profiling Gene Expression Induced by Protease-Activated Receptor 2 (PAR2) Activation in Human Kidney Cells

(2010) Jacky Y. Suen et al.   PLoS One

Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responsesin vitroandin vivo

(2009) T Kanke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes: Dissociation of Adipocyte Hypertrophy From Inflammation

(2009) C. Y. Han et al.   DIABETES

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction

(2008) Prasad Rallabhandi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY