An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

Mast Cells Contribute to Autoimmune Inflammatory Arthritis via Their Tryptase/Heparin Complexes

(2014) K. Shin et al.   JOURNAL OF IMMUNOLOGY

An Alternate Perspective on the Roles of TIMPs and MMPs in Pathology

(2011) Craig S. Moore et al.   AMERICAN JOURNAL OF PATHOLOGY

Protease-activated receptor 2, rather than protease-activated receptor 1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis

(2011) Meilang Xue et al.   ARTHRITIS AND RHEUMATISM

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)

(2011) JY Suen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cathepsin S Is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-Dependent Mechanism in Mice

(2011) Fiore Cattaruzza et al.   GASTROENTEROLOGY

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

(2011) Mark Baugh et al.   JOURNAL OF AUTOIMMUNITY

Structure, function and pathophysiology of protease activated receptors

(2011) Mark N. Adams et al.   PHARMACOLOGY & THERAPEUTICS

Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis

(2010) W. R. Ferrell et al.   ANNALS OF THE RHEUMATIC DISEASES

Mast cell-derived tryptase inhibits apoptosis of human rheumatoid synovial fibroblasts via rho-mediated signaling

(2010) Norifumi Sawamukai et al.   ARTHRITIS AND RHEUMATISM

Mast cell proteases: multifaceted regulators of inflammatory disease

(2010) G. Pejler et al.   BLOOD

Nafamostat mesilate attenuates colonic inflammation and mast cell infiltration in the experimental colitis

(2010) Eun-Young Cho et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activation of Protease Activated Receptor 2 by Exogenous Agonist Exacerbates Early Radiation Injury in Rat Intestine

(2010) Junru Wang et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Novel Agonists and Antagonists for Human Protease Activated Receptor 2

(2010) Grant D. Barry et al.   JOURNAL OF MEDICINAL CHEMISTRY

An essential role for mast cells as modulators of neutrophils influx in collagen-induced arthritis in the mouse

(2010) Tatiana Aparecida Pimentel et al.   LABORATORY INVESTIGATION

Serine proteases and protease-activated receptor 2-dependent allodynia: A novel cancer pain pathway

(2010) D. K. Lam et al.   PAIN

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts

(2009) Nathalie Amiable et al.   BONE

Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responsesin vitroandin vivo

(2009) T Kanke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Extracellular Proteases as Targets for Drug Development

(2009) Mare Cudic et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

A novel system allowing long-term simultaneous video-electroencephalography recording, drug infusion and blood sampling in rats

(2009) Leena van Raay et al.   JOURNAL OF NEUROSCIENCE METHODS

Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases

(2009) Tien-Yu Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice

(2008) R Costa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protease-activated receptor-2 regulates trypsin expression in the brain and protects against seizures and epileptogenesis

(2008) Rink-Jan Lohman et al.   NEUROBIOLOGY OF DISEASE

Gastrointestinal roles for proteinase-activated receptors in health and disease

(2007) A Kawabata et al.   BRITISH JOURNAL OF PHARMACOLOGY