The Concise Guide to PHARMACOLOGY 2013/14: Ligand-Gated Ion Channels

Potency of GABA at human recombinant GABAA receptors expressed in Xenopus oocytes: a mini review

(2013) Nasiara Karim et al.   AMINO ACIDS

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Influence of GluN2 subunit identity on NMDA receptor function

(2013) D.J.A. Wyllie et al.   NEUROPHARMACOLOGY

Functional Insights from Glutamate Receptor Ion Channel Structures

(2012) Janesh Kumar et al.   Annual Review of Physiology

Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors

(2012) W Nörenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Closer Look at the High Affinity Benzodiazepine Binding Site on GABAA Receptors

(2012) Erwin Sigel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subunit-Selective Allosteric Inhibition of Glycine Binding to NMDA Receptors

(2012) K. B. Hansen et al.   JOURNAL OF NEUROSCIENCE

TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner

(2012) S. Edman et al.   NEUROPHARMACOLOGY

α4β2 neuronal nicotinic receptor positive allosteric modulation: An approach for improving the therapeutic index of α4β2 nAChR agonists in pain

(2011) Chih-Hung Lee et al.   BIOCHEMICAL PHARMACOLOGY

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Naturally-expressed nicotinic acetylcholine receptor subtypes

(2011) Jie Wu et al.   BIOCHEMICAL PHARMACOLOGY

Allosteric modulation of glycine receptors

(2011) Gonzalo E. Yevenes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist

(2011) S McKay et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-HT3 receptors: potential of individual isoforms for personalised therapy

(2011) Beate Niesler   CURRENT OPINION IN PHARMACOLOGY

Molecular basis of NMDA receptor functional diversity

(2011) Pierre Paoletti   EUROPEAN JOURNAL OF NEUROSCIENCE

Medicinal chemistry of ρ GABACreceptors

(2011) Clarissa KL Ng et al.   Future Medicinal Chemistry

The GABAA Receptor  + - Interface: A Novel Target for Subtype Selective Drugs

(2011) J. Ramerstorfer et al.   JOURNAL OF NEUROSCIENCE

Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors

(2011) A. J. Thompson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Binding Sites for Bilobalide, Diltiazem, Ginkgolide, and Picrotoxinin at the 5-HT3 Receptor

(2011) A. J. Thompson et al.   MOLECULAR PHARMACOLOGY

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia

(2011) Wei Xiong et al.   Nature Chemical Biology

Net(o) excitement for kainate receptors

(2011) Juan Lerma   NATURE NEUROSCIENCE

GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses

(2011) Bernhard Luscher et al.   NEURON

The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits

(2011) Alexander C. Jackson et al.   NEURON

The Dynamic Modulation of GABAA Receptor Trafficking and Its Role in Regulating the Plasticity of Inhibitory Synapses

(2011) Mansi Vithlani et al.   PHYSIOLOGICAL REVIEWS

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Agonist activation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2011) J. K. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associated proteins: The universal toolbox controlling ligand gated ion channel function

(2010) Tanguy Araud et al.   BIOCHEMICAL PHARMACOLOGY

Agonists and Antagonists Bind to an A-A Interface in the Heteromeric 5-HT3AB Receptor

(2010) M. Lochner et al.   BIOPHYSICAL JOURNAL

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

(2010) Joel R Gever et al.   BRITISH JOURNAL OF PHARMACOLOGY

Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands -in vitro and in vivo characterization

(2010) S Khom et al.   BRITISH JOURNAL OF PHARMACOLOGY

GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

(2010) Richard W. Olsen et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Molecular Structure of Ionotropic Glutamate Receptors

(2010) A.A. Kaczor et al.   CURRENT MEDICINAL CHEMISTRY

In vitro binding characteristics of [3H]AZ11637326, a novel α7-selective neuronal nicotinic receptor agonist radioligand

(2010) John C. Gordon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective Gβγ Modulation

(2010) Gonzalo E. Yevenes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIC-3 Exclusively Enhances the Surface Expression of Human Homomeric 5-Hydroxytryptamine Type 3A (5-HT3A) Receptors Despite Direct Interactions with 5-HT3A, -C, -D, and -E Subunits

(2010) Jutta Walstab et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fragrant Dioxane Derivatives Identify β1-Subunit-containing GABAAReceptors

(2010) Olga A. Sergeeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E

(2010) Johannes Kapeller et al.   JOURNAL OF COMPARATIVE NEUROLOGY

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(2010) T. Dinklo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification and Characterization of Novel NMDA Receptor Antagonists Selective for NR2A- over NR2B-Containing Receptors

(2010) E. Bettini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Biochemistry, Ultrastructure, and Subunit Assembly Mechanism of AMPA Receptors

(2010) Terunaga Nakagawa   MOLECULAR NEUROBIOLOGY

Mapping the Ligand Binding Sites of Kainate Receptors: Molecular Determinants of Subunit-Selective Binding of the Antagonist [3H]UBP310

(2010) P. T. Atlason et al.   MOLECULAR PHARMACOLOGY

Neurochemicals for the Investigation of GABAC Receptors

(2010) Graham A. R. Johnston et al.   NEUROCHEMICAL RESEARCH

Benzodiazepine modulation of the rat GABAA receptor α4β3γ2L subtype expressed in Xenopus oocytes

(2010) Haitao You et al.   NEUROPHARMACOLOGY

Ginkgolide B and bilobalide block the pore of the 5-HT3 receptor at a location that overlaps the picrotoxin binding site

(2010) Andrew J. Thompson et al.   NEUROPHARMACOLOGY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

5-HT3 receptors: Role in disease and target of drugs

(2010) Jutta Walstab et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of Ionotropic Glutamate Receptors by Their Auxiliary Subunits

(2010) Susumu Tomita   PHYSIOLOGY

Influence of the NR3A subunit on NMDA receptor functions

(2010) Maile A. Henson et al.   PROGRESS IN NEUROBIOLOGY

GABAA,slow: causes and consequences

(2010) Marco Capogna et al.   TRENDS IN NEUROSCIENCES

Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons

(2010) Andrew K. Jones et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gating and permeation of kainate receptors: differences unveiled

(2010) David Perrais et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mysterious α6-containing nAChRs: function, pharmacology and pathophysiology

(2009) Ke-chun Yang et al.   ACTA PHARMACOLOGICA SINICA

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

(2009) Prisca Honore et al.   BEHAVIOURAL BRAIN RESEARCH

Structural and functional diversity of native brain neuronal nicotinic receptors

(2009) Cecilia Gotti et al.   BIOCHEMICAL PHARMACOLOGY

Insight in nAChR subtype selectivity from AChBP crystal structures

(2009) Prakash Rucktooa et al.   BIOCHEMICAL PHARMACOLOGY

TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

(2009) T.A. Hauser et al.   BIOCHEMICAL PHARMACOLOGY

RNA editing and its impact on GABAAreceptor function

(2009) Chammiran Daniel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanism of action of species-selective P2X7 receptor antagonists

(2009) Anton D Michel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

(2009) Diana L Donnelly-Roberts et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure-Activity Relationships of Neuroactive Steroids Acting on the GABAA Receptor

(2009) Adriana Veleiro et al.   CURRENT MEDICINAL CHEMISTRY

Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors

(2009) Guo-Dong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different binding modes of tropeines mediating inhibition and potentiation of α1 glycine receptors

(2009) Gábor Maksay et al.   JOURNAL OF NEUROCHEMISTRY

Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

(2009) D. Belelli et al.   JOURNAL OF NEUROSCIENCE

In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of  7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile

(2009) J. Malysz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ion-dependent gating of kainate receptors

(2009) Derek Bowie   JOURNAL OF PHYSIOLOGY-LONDON

Direct Subunit-Dependent Multimodal 5-Hydroxytryptamine3 Receptor Antagonism by Methadone

(2009) T. Z. Deeb et al.   MOLECULAR PHARMACOLOGY

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Modulation of Glycine Receptor Function by the Synthetic Cannabinoid HU210

(2009) Reyhan Demir et al.   PHARMACOLOGY

The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function

(2009) Jörg Ahrens et al.   PHARMACOLOGY

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

The P2X7 receptor–pannexin connection to dye uptake and IL-1β release

(2009) Pablo Pelegrin et al.   Purinergic Signalling

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine

(2008) Zhe Yang et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

(2008) Brad A. Acker et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antimalarial drugs inhibit human 5-HT3and GABAAbut not GABACreceptors

(2008) A J Thompson et al.   BRITISH JOURNAL OF PHARMACOLOGY

RIC-3: a nicotinic acetylcholine receptor chaperone

(2008) N S Millar   BRITISH JOURNAL OF PHARMACOLOGY

GABAAReceptor Subtype-Selective Efficacy: TPA023, an α2/α3 Selective Non-sedating Anxiolytic and α5IA, an α5 Selective Cognition Enhancer

(2008) John R. Atack   CNS Neuroscience & Therapeutics

The 5-HT3BSubunit Confers Spontaneous Channel Opening and Altered Ligand Properties of the 5-HT3Receptor

(2008) Xiang-Qun Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy

(2008) Sabrina A. Eichler et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Characterisation of 5-HT3C, 5-HT3Dand 5-HT3Ereceptor subunits: evolution, distribution and function

(2008) Joanna D. Holbrook et al.   JOURNAL OF NEUROCHEMISTRY

High Intracellular Chloride Slows the Decay of Glycinergic Currents

(2008) S. J. Pitt et al.   JOURNAL OF NEUROSCIENCE

P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes

(2008) U. Lalo et al.   JOURNAL OF NEUROSCIENCE

Shuffling the Deck Anew: How NR3 Tweaks NMDA Receptor Function

(2008) Nora A. Cavara et al.   MOLECULAR NEUROBIOLOGY

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

(2008) Tija C. Jacob et al.   NATURE REVIEWS NEUROSCIENCE

Extending the analysis of nicotinic receptor antagonists with the study of α6 nicotinic receptor subunit chimeras

(2008) R PAPKE et al.   NEUROPHARMACOLOGY

The anti-convulsant stiripentol acts directly on the GABAA receptor as a positive allosteric modulator

(2008) Janet L. Fisher   NEUROPHARMACOLOGY

Novel compounds selectively enhance δ subunit containing GABAA receptors and increase tonic currents in thalamus

(2008) K.A. Wafford et al.   NEUROPHARMACOLOGY

The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature

(2008) David Lodge   NEUROPHARMACOLOGY

Antagonism of recombinant and native GluK3-containing kainate receptors

(2008) David Perrais et al.   NEUROPHARMACOLOGY

Kainate receptors: Pharmacology, function and therapeutic potential

(2008) David E. Jane et al.   NEUROPHARMACOLOGY

Native glycine receptor subtypes and their physiological roles

(2008) Joseph W. Lynch   NEUROPHARMACOLOGY

The 5-HT3 receptor – the relationship between structure and function

(2008) Nicholas M. Barnes et al.   NEUROPHARMACOLOGY

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

Diversity of vertebrate nicotinic acetylcholine receptors

(2008) Neil S. Millar et al.   NEUROPHARMACOLOGY

A nomenclature for ligand-gated ion channels

(2008) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Serotonin type 3 receptor genes:HTR3A, B, C, D, E

(2008) Beate Niesler et al.   PHARMACOGENOMICS

International Union of Pharmacology. LXX. Subtypes of  -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

(2008) R. W. Olsen et al.   PHARMACOLOGICAL REVIEWS

Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist

(2008) C. Madry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels

(2008) S. Chaumont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinic receptors, allosteric proteins and medicine

(2008) Jean-Pierre Changeux et al.   TRENDS IN MOLECULAR MEDICINE

3B but which 3B? And that's just one of the questions: the heterogeneity of human 5-HT3 receptors

(2008) A JENSEN et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits

(2008) Aaron D. Milstein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intracellular machinery for the transport of AMPA receptors

(2007) J A Esteban   BRITISH JOURNAL OF PHARMACOLOGY

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed inXenopus laevisoocytes

(2007) Philip E. Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

GABAA receptor subtypes underlying general anesthesia

(2007) Robert P. Bonin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR