New perspectives on the thrombotic complications of haemolysis

Hemolysis, Pump Thrombus, and Neurologic Events in Continuous-Flow Left Ventricular Assist Device Recipients

(2014) Bryan A. Whitson et al.   ANNALS OF THORACIC SURGERY

Neutrophil Extracellular Traps Promote Thrombin Generation Through Platelet-Dependent and Platelet-Independent Mechanisms

(2014) Travis J. Gould et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

(2014) G. Chen et al.   BLOOD

Baseline characteristics and disease burden in patients in the International Paroxysmal Nocturnal Hemoglobinuria Registry

(2014) H. Schrezenmeier et al.   HAEMATOLOGICA

Venous Thromboembolism in Adults with Sickle Cell Disease: A Serious and Under-recognized Complication

(2013) Rakhi P. Naik et al.   AMERICAN JOURNAL OF MEDICINE

Thrombosis in paroxysmal nocturnal hemoglobinuria

(2013) A. Hill et al.   BLOOD

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Aged erythrocytes: a fine wine or sour grapes?

(2013) B. Cohen et al.   BRITISH JOURNAL OF ANAESTHESIA

Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

(2013) Peter Hillmen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hemolysis in Pediatric Patients Receiving Centrifugal-Pump Extracorporeal Membrane Oxygenation

(2013) Song Lou et al.   CRITICAL CARE MEDICINE

Long-term risks after splenectomy among 8,149 cancer-free American veterans: a cohort study with up to 27 years follow-up

(2013) S. Y. Kristinsson et al.   HAEMATOLOGICA

Deep vein thrombosis in association with acute intravascular haemolysis in glucose-6-phosphate dehydrogenase deficiency: a unique case

(2013) P. A. Thompson et al.   INTERNAL MEDICINE JOURNAL

Clinical signs and symptoms associated with increased risk for thrombosis in patients with paroxysmal nocturnal hemoglobinuria from a Korean Registry

(2013) Jong Wook Lee et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Hemolysis in left ventricular assist device: A retrospective analysis of outcomes

(2013) Ashwin K. Ravichandran et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Mechanisms of hemolysis-associated platelet activation

(2013) C. C. Helms et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Unexpected Abrupt Increase in Left Ventricular Assist Device Thrombosis

(2013) Randall C. Starling et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular haemoglobin upregulates and binds to tissue factor on macrophages: Implications for coagulation and oxidative stress

(2013) N. Bahl et al.   THROMBOSIS AND HAEMOSTASIS

Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro

(2013) Sherry L. Spinelli et al.   TRANSFUSION

Role of Echocardiography in Patients With Intravascular Hemolysis Due to Suspected Continuous-Flow LVAD Thrombosis

(2013) Nowell M. Fine et al.   JACC-Cardiovascular Imaging

Acute silent cerebral ischemia and infarction during acute anemia in children with and without sickle cell disease

(2012) M. M. Dowling et al.   BLOOD

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Molecular Link between Intravascular Hemolysis and Vascular Occlusion in Sickle Cell Disease

(2012) Zhou Zhou et al.   Current Vascular Pharmacology

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease

(2012) Mark T. Gladwin et al.   JOURNAL OF CLINICAL INVESTIGATION

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation

(2012) Olivier Rubin et al.   TRANSFUSION

Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival

(2011) R. J. Kelly et al.   BLOOD

Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron

(2011) E. A. Hod et al.   BLOOD

Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion

(2011) Chenell Donadee et al.   CIRCULATION

Biomarkers of Inflammation, Growth Factor, and Coagulation Activation in Patients With Sickle Cell Disease

(2011) M. H. Qari et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Treatment of paroxysmal nocturnal hemoglobinuria in the era of eculizumab

(2011) Alexander Röth et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model

(2010) W. Hu et al.   BLOOD

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

(2010) E. A. Hod et al.   BLOOD

Platelet aggregation is inhibited by a nitric oxide-like factor released from human neutrophils in vitro

(2010) R. W. Faint et al.   BRITISH JOURNAL OF HAEMATOLOGY

Heme Amplifies the Innate Immune Response to Microbial Molecules through Spleen Tyrosine Kinase (Syk)-dependent Reactive Oxygen Species Generation

(2010) Patricia L. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

(2008) Francesca Vinchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Virchow and his triad: a question of attribution

(2008) Catherine N. Bagot et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cell-Free Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death

(2008) Charles Natanson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Heme induces endothelial tissue factor expression: potential role in hemostatic activation in patients with hemolytic anemia

(2008) B. N. Y. SETTY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Delayed adverse vascular events after splenectomy in hereditary spherocytosis

(2008) R. F. SCHILLING et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS