Article
Neurosciences
Nawshaba Nawreen, Mark L. Baccei, James P. Herman
Summary: Post-traumatic stress disorder (PTSD) causes functional changes in the infralimbic cortex, leading to reduced synaptic drive and intrinsic excitability of pyramidal neurons. This results in a lasting reduction in prefrontal cortex activity, supporting the link between traumatic stress and prefrontal hypoactivity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Wei Wang, Qing Cao, Tao Tan, Fengwei Yang, Jamal B. Williams, Zhen Yan
Summary: Research suggests that targeting EHMT2 can reverse the repressive H3K9me2 histone mark in the brain of P301S Tau mice, improving spatial and recognition memory deficits. In addition, EHMT inhibition can normalize neuronal excitability and glutamatergic synaptic transmission in the PFC of P301S Tau mice. UNC0642 treatment has been shown to regulate dysregulated genes and may be used to treat cognitive and synaptic deficits in neurodegenerative diseases associated with tauopathies.
Article
Biochemistry & Molecular Biology
Daisuke Yamada, Junpei Takahashi, Keita Iio, Hiroshi Nagase, Akiyoshi Saitoh
Summary: The study showed that KNT-127 suppressed glutamate release from the presynaptic site in the PL-PFC, reducing neuronal excitability. This suggests that the inhibitory effects of KNT-127 on PL-PFC activity may contribute to its anxiolytic-like effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Mayra Torres-Flores, Fernando Pena-Ortega
Summary: The study found that Ap can affect PFC excitability and synaptic plasticity balance, damaging PFC-dependent functions such as working memory and cognitive flexibility, which may constitute the foundations of the early alterations in executive functions in AD patients.
Article
Chemistry, Medicinal
Yan-yan Guo, Ying Zhou, Yu-jiao Li, An Liu, Jiao Yue, Qing-qing Liu, Le Yang, Yu-mei Wu, Shui-bing Liu, Kun Zhang, Ming-gao Zhao
Summary: This study reveals that Scutellarin has a protective effect against stress-induced anxiety in mice by restoring neurotransmitter levels and improving behavioral abnormalities.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ming-Fen Ho, Cheng Zhang, Irene Moon, Xiujuan Zhu, Brandon J. Coombes, Joanna Biernacka, Michelle Skime, Tyler S. Oesterle, Victor M. Karpyak, Kristen Schmidt, Kate Gliske, Quyen Ngo, Cedric Skillon, Marvin D. Seppala, Hu Li, Richard M. Weinshilboum
Summary: This study used single-cell sequencing technology to investigate the response of OUD patients to oxycodone and buprenorphine. The results revealed that buprenorphine significantly influenced transcriptional regulation in glial cells, while oxycodone induced type I interferon signaling in multiple cell types. These findings provide novel mechanistic insights into the actions of drugs at the single-cell level.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Shuwen Yue, Yunwanbin Wang, Zi-Jun Wang
Summary: IGF1 regulates excitatory synaptic transmission in adult prefrontal cortex via the interaction between IGF1R-dependent signaling pathway and mGluR1-mediated AMPAR endocytosis.
Letter
Clinical Neurology
M. Tzioras, A. J. Stevenson, D. Boche, T. L. Spires-Jones
Summary: Microglia in schizophrenia patients' brains engulf synaptic material similarly to control brains, and microgliosis levels are also similar between schizophrenia and control brains.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv, Feifei Wang, Lan Ma, Xing Liu
Summary: This study found that increased norepinephrine release from the locus coeruleus to the medial prefrontal cortex during contextual fear conditioning is crucial for memory tagging and remote memory storage. It is regulated by the ventrolateral periaqueductal grey and can be promoted by activating beta1-adrenergic receptor signaling in juvenile mice.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Haneen Kayyal, Sailendrakumar Kolatt Chandran, Adonis Yiannakas, Nathaniel Gould, Mohammad Khamaisy, Kobi Rosenblum
Summary: The research reveals the vital role of reciprocal connectivity between the anterior insular cortex and the medial prefrontal cortex in animals' experience of novel taste, fear response, and learning, providing important insights for understanding related psychiatric disorders.
Article
Biochemistry & Molecular Biology
Hiroki Toyoda, Kohei Koga
Summary: This study found that adolescent nicotine exposure enhances synaptic transmission, plasticity, and intrinsic excitability in layer V pyramidal neurons of the mice insular cortex in adulthood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Justine Magnuson, Mehmet A. A. Ozdemir, Elon Mathieson, Sofia Kirkman, Brice Passera, Sumientra Rampersad, Alyssa B. B. Dufour, Dana Brooks, Alvaro Pascual-Leone, Peter J. J. Fried, Mouhsin M. M. Shafi, Recep A. A. Ozdemir
Summary: This study comprehensively evaluated the neuromodulatory effects of various rTMS protocols on corticospinal excitability. The results showed that these protocols did not significantly modulate corticospinal excitability and had poor reproducibility. These findings question the effectiveness and reliability of widely used rTMS techniques in modulating corticospinal excitability.
Article
Neurosciences
Kang Hyun Leem, Sanga Kim, Hee Won Kim, Hae Jeong Park
Summary: In this study, we examined the role of miR-325-3p, miR-326-3p, and miR-330-5p in regulating TH and manic-like behaviors in sleep-deprived rats. We observed an upregulation in TH expression and a downregulation in miRNA-325-3p, miR-326-3p, and miR-330-5p expressions in the prefrontal cortex of sleep-deprived rats, along with increased manic-like behaviors. We also found that miR-330-5p can repress TH expression through direct binding to its target site.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Xiangyang Xiong, Yan Zuo, Lu Cheng, Zhenyu Yin, Tianpeng Hu, Mengtian Guo, Zhaoli Han, Xintong Ge, Wenzhu Li, Yan Wang, Dong Wang, Conglin Wang, Lan Zhang, Yaodan Zhang, Qiang Liu, Fanglian Chen, Ping Lei
Summary: This study found that modafinil improves learning and memory, reduces inflammation, and inhibits neuronal pyroptosis. It also upregulates brain-derived neurotrophic factor and synaptic activity. These findings suggest that modafinil can alleviate cognitive decline following sleep deprivation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Janna D. Lendner, Niels Niethard, Bryce A. Mander, Frank J. van Schalkwijk, Sigrid Schuh-Hofer, Hannah Schmidt, Robert T. Knight, Jan Born, Matthew P. Walker, Jack J. Lin, Randolph F. Helfrich
Summary: The study shows that non-oscillatory brain activity during REM sleep plays a key role in the sleep-dependent recalibration of neural population dynamics. The extent of REM sleep recalibration predicts the success of overnight memory consolidation by favoring remembering over forgetting. This non-oscillatory mechanism explains how REM sleep enhances long-term memory in humans.
Article
Biochemistry & Molecular Biology
Feifei Ge, Ping Mu, Rong Guo, Li Cai, Zheng Liu, Yan Dong, Yanhua H. Huang
Summary: Chronic REM sleep disturbance enhances neural activity in the medial habenula possibly through compromised TASK-3 function, suggesting a key molecular substrate for affect regulation changes.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Terra A. Schall, William J. Wright, Yan Dong
Summary: This study explores the role of drug addiction in the reward circuitry and the regulatory effects of FSIs, highlighting the significant impact of FSIs on tilting the functional output of NAc towards a motivational state favoring drug seeking and relapse.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Junshi Wang, King-Lun Li, Avani Shukla, Ania Beroun, Masago Ishikawa, Xiaojie Huang, Yao Wang, Yao Q. Wang, Yue Yang, Noah D. Bastola, Hugh H. Huang, Lily E. Kramer, Terry Chao, Yanhua H. Huang, Susan R. Sesack, Eric J. Nestler, Oliver M. Schlueter, Yan Dong
Summary: The study shows that the developmental synaptogenic mechanism mediated by astrocyte-released thrombospondins (TSPs) and their neuronal receptor alpha 2 delta-1 is utilized during cocaine experience to induce spinogenesis and the generation of AMPA receptor-silent glutamatergic synapses in the adult nucleus accumbens shell (NAcSh). Further research indicates that disruption of TSP2-alpha 2 delta-1-mediated spinogenesis and synapse generation in NAcSh reduces cue-induced cocaine seeking after withdrawal from cocaine self-administration and cue-induced reinstatement of cocaine seeking after drug extinction.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yao Wang, Rong Guo, Bo Chen, Tanbin Rahman, Li Cai, Yizhi Li, Yan Dong, George C. Tseng, Jidong Fang, Marianne L. Seney, Yanhua H. Huang
Summary: Cocaine withdrawal leads to gene expression and electrophysiological changes in melanin-concentrating hormone neurons in the lateral hypothalamus, affecting REM sleep. Stimulation of these neurons enhances REM sleep quality and quantity after long-term withdrawal.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Yao Q. Wang, Yanhua H. Huang, Saju Balakrishnan, Lidong Liu, Yu Tian Wang, Eric J. Nestler, Oliver M. Schluter, Yan Dong
Summary: This study elucidates the dynamic interactions between AMPARs and NMDARs during the generation and maturation of silent synapses in the NAc after cocaine experience. The findings provide a mechanistic basis for manipulating new synaptic contacts and potentially new neural network patterns created by these synapses for therapeutic benefit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Anesthesiology
Yao Q. Wang, Junshi Wang, Sun-hui Xia, Howard B. Gutstein, Yanhua H. Huang, Oliver M. Schluter, Jun-Li Cao, Yan Dong
Summary: The study revealed that pain experience can induce remodeling of neural circuits between the mediodorsal thalamus and the anterior cingulate cortex, leading to the generation of silent synapses that contribute to allodynia and hyperalgesia. These silent synapses undergo changes over time post-pain experience, affecting pain sensitivity.
Editorial Material
Neurosciences
Alexander K. Zinsmaier, Yan Dong
BIOLOGICAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Junshi Wang, Leanne M. Holt, Hugh H. Huang, Susan R. Sesack, Eric J. Nestler, Yan Dong
Summary: Drug addiction poses a significant biomedical challenge for neuroscience research, with astrocytes emerging as key players alongside neural mechanisms. Cocaine-induced changes in astrocyte activity play a crucial role in shaping synaptic and circuit adaptations, influencing drug seeking behaviors. Targeting astrocytic substrates may hold therapeutic potential in ameliorating drug-induced neuroplasticity for behavioral benefits.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Alexander K. Zinsmaier, Yan Dong, Yanhua H. Huang
Summary: Cocaine craving, seeking, and relapse are partially mediated by adaptive changes in the brain reward circuits induced by cocaine. The nucleus accumbens integrates emotional and motivational inputs and prioritizes them for the reward system. Medium spiny neurons in the NAc show complex adaptations following cocaine experience, influenced by various factors such as cocaine regimen, withdrawal time, cell type, location, and input/output projections.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Jeffrey G. Mellott, Matasha Dhar, Amir Mafi, Nick Tokar, Bradley D. Winters
Summary: Sound localization depends on brainstem neurons comparing information from both ears. In the lateral superior olive (LSO), there are both excitatory and inhibitory neurons, with excitatory neurons being more numerous and having different projection patterns compared to inhibitory neurons. Inhibitory LSO neurons predominantly project ipsilaterally, while excitatory neurons show a mix of contralateral and ipsilateral projections, with some cells specializing in low frequency hearing.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
William J. Wright, Yan Dong
Summary: Glutamatergic synapses play a crucial role in encoding cocaine memories, with the generation of silent synapses during cocaine experience contributing to the consolidation of these memories. These silent synapses alternate between AMPAR-absent and AMPAR-containing states after cue-induced retrieval of cocaine memories, reflecting the dynamic process of memory destabilization and reconsolidation in response to cocaine-associated cues.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Rong Guo, Dylan Thomas Vaughan, Ana Lourdes Almeida Rojo, Yanhua H. Huang
Summary: This review critically summarizes the mechanisms by which sleep influences reward function and suggests that improving sleep quality may serve as complementary therapy for treating substance use disorders. It also highlights the potential of formulating sleep metrics for predicting individual susceptibility to substance use disorders and other reward-associated psychiatric diseases.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biology
Hariprakash Haragopal, Bradley D. Winters
Summary: This article investigates the electrophysiological and morphological characteristics of inhibitory and excitatory principal neurons in the murine lateral superior olive. The study reveals cellular diversity that may underlie dual timing and intensity sound localization functions as well as segregation of information in higher processing centers. Inhibitory and excitatory principal neurons exhibit distinct projection patterns and intrinsic cellular properties, which contribute to the segregation of information in higher processing centers.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
