Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Article
Biochemistry & Molecular Biology
Gee Euhn Choi, Chang Woo Chae, Mo Ran Park, Jee Hyeon Yoon, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han
Summary: Exposure to prenatal stress has irreversible effects on neurogenesis and can lead to cognitive and neuropsychiatric abnormalities in adulthood. This study identified glucocorticoid as a key factor impairing neurogenesis and inducing abnormal behaviors. The researchers also discovered that astrocytes derived from neural stem cells exhibited neurotoxic properties after glucocorticoid treatment. Additionally, the study revealed that cortisol-treated astrocytic conditioned media inhibited glutamatergic synaptic formation and transmission in differentiating neurons. Restoring the expression of neuroligin 1 and neuronal FGFR1 through FGF2 treatment improved glutamatergic synaptogenesis and overall neurogenesis. The findings highlight the importance of understanding the impact of prenatal stress on brain development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Neurosciences
Xuelian Hu, Guangdan Yu, Xiang Liao, Lan Xiao
Summary: Astrocytes and oligodendroglial lineage cells play important roles in the central nervous system. They communicate with each other through connexin and network structures, modulating various physiological processes in the brain. These interactions are involved in myelination, protecting the integrity of the blood-brain barrier, and regulating synaptogenesis and neural activity.
NEUROSCIENCE BULLETIN
(2023)
Review
Cell Biology
Lili Shan, Tongran Zhang, Kevin Fan, Weibo Cai, Huisheng Liu
Summary: Astrocytes play a crucial role in the central nervous system by dynamically communicating with neurons to regulate synaptic formation and maturation. Their heterogeneity allows them to boost synaptogenesis region-specifically. Future research may focus on utilizing organoids generated from human induced pluripotent stem cells to study the signaling pathways employed by astrocytes in synaptic development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Pengfei Xia, Francesca Logiacco, Yimin Huang, Helmut Kettenmann, Marcus Semtner
Summary: Histamine indirectly regulates microglial calcium levels and phagocytic activity via astrocyte histamine receptor-controlled purinergic signaling.
Article
Neurosciences
Hong-Ju Yang, Briana J. Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Glutamate negatively regulates the rewarding effects of cocaine in the nucleus accumbens, but excess glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Akshata A. Almad, Arens Taga, Jessica Joseph, Sarah K. Gross, Connor Welsh, Aneesh Patankar, Jean -Philippe Richard, Khalil Rust, Aayush Pokharel, Caroline Plott, Mauricio Lillo, Raha Dastgheyb, Kevin Eggan, Norman Haughey, Jorge E. Contreras, Nicholas J. Maragakis
Summary: This study demonstrates that Cx43 hemichannels play a role in the progression of ALS by mediating astrocyte communication and that blocking these channels can provide neuroprotection for motor neurons. Additionally, Cx43 expression is up-regulated in ALS patients' tissue and cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Stephan Schacke, Joanna Kirkpatrick, Amy Stocksdale, Reinhard Bauer, Christian Hagel, Lars Bjoern Riecken, Helen Morrison
Summary: Astrocytes play a crucial role in brain function and behavior through their involvement in synaptic signaling and ion homeostasis. Ezrin, an essential protein in astrocytes, has been found to contribute to synaptic transmission and astrocyte activation. Deletion of Ezrin in mice resulted in behavioral changes and showed a protective effect in an experimental ischemic stroke. These findings suggest the importance of Ezrin in astrocyte functions and its potential therapeutic implications.
Article
Biotechnology & Applied Microbiology
Mayur Doke, Fatah Kashanchi, Mansoor A. Khan, Thangavel Samikkannu
Summary: Astrocytes play a crucial role in regulating energy metabolism in the CNS, and miRNA-mediated changes in astrocyte function may contribute to neurodegeneration in individuals with HIV infection and cocaine abuse. Next-generation sequencing identified significant alterations in miRNA expression in astrocytes exposed to HIV-1 Tat and cocaine, with implications for potential biomarkers and therapeutic targets. This study highlights the impact of miRNAs on astrocyte energy metabolism and suggests their potential role in HIV and cocaine-induced neurodegeneration.
Article
Biochemistry & Molecular Biology
Natasha Ustyanovska Avtenyuk, Ghizlane Choukrani, Emanuele Ammatuna, Toshiro Niki, Ewa Cendrowicz, Harm Jan Lourens, Gerwin Huls, Valerie R. Wiersma, Edwin Bremer
Summary: In this study, Gal-9 treatment was found to induce significant membrane alterations in cancer cells by externalizing phosphatidyl serine (PS) and downregulating the anti-phagocytic regulator CD47. It was also shown to trigger trogocytosis and enhance antibody-dependent cellular phagocytosis of cancer cells by activating neutrophils and mobilizing granules. Moreover, Gal-9 treatment resulted in decreased cancer cell adhesion and potent cytotoxicity mediated by neutrophils.
Article
Neurosciences
Lei Chen, Ning Yang, Yue Li, Yitong Li, Jingshu Hong, Qian Wang, Kaixi Liu, Dengyang Han, Yongzheng Han, Xinning Mi, Chengmei Shi, Ying Zhou, Zhengqian Li, Taotao Liu, Xiangyang Guo
Summary: The study showed that CCK-8 alleviates cognitive impairment and promotes glutamatergic synaptogenesis by inhibiting the induction of A1 reactive astrocytes and the activation of microglia, suggesting it as a potential therapeutic target for dNCR.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Environmental Sciences
Changjiang Liu, Jiayuan Qu, Mingzhu Wu, Xu Huang, Lianbing Li
Summary: This study revealed that CYP can suppress testosterone biosynthesis and cause abnormal alterations in testicular histomorphology and ultrastructures. Non-coding RNAs and the Jak/Stat pathway play critical roles in the CYP-mediated testosterone suppression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Yucheng Liu, Xinyan Wang, Wucheng Zhu, Zhongheng Sui, Xiangqing Wei, Yang Zhang, Jiansong Qi, Yanhong Xing, Wuyang Wang
Summary: This study reveals the mechanism by which TRPML1 inhibits autophagy to regulate apoptosis, involving disrupted mitochondrial turnover, elevated ROS, DNA damage, and p53 activation. These findings have potential clinical implications for treating melanoma and glioblastoma.
Review
Immunology
Makoto Kinoshita, Tatsusada Okuno
Summary: Recently, it has been found that astrocytes in the CNS are targeted by autoantibodies in autoimmune diseases. Aquaporin4 (AQP4) is the most commonly targeted antigen in astrocyte-related autoimmune responses. This review discusses the clinical and pathological aspects of AQP4-mediated astrocyte diseases, as well as the role of anti-AQP4 antibodies in their pathogenesis. Furthermore, the mechanism of immune dysregulation leading to the production of autoantibodies targeting astrocytes is explored, along with the proposed hypothesis.
INFLAMMATION AND REGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Tatiana Leiva-Rodriguez, David Romeo-Guitart, Mireia Herrando-Grabulosa, Pau Munoz-Guardiola, Miriam Polo, Celia Banuls, Valerie Petegnief, Assumpcio Bosch, Jose Miguel Lizcano, Nadezda Apostolova, Joaquim Fores, Caty Casas
Summary: The experimental model of spinal root avulsion provides insights into the relationship between GRP78 chaperone and mitophagy, paving way for novel therapeutic options for neuroprotection.
Article
Computer Science, Software Engineering
Xiaojie Huang
Summary: This paper proposes a deep self-adaptive network (DSA-Net) for effectively detecting moving objects in low-luminance scenes. The network incorporates three mechanisms and a weakly fine-tuning strategy and outperforms state-of-the-art methods in experiments.
Article
Mathematics
Xiaojie Huang, Ziwen Huang, Jian-Bo Lv
Summary: In this paper, it is proven that planar graphs without 4-cycles and 6-cycles can be partitioned into (linear forest-2, forest) sets.
GRAPHS AND COMBINATORICS
(2023)
Review
Infectious Diseases
Chi Zhou, Yaxin Wu, Yang Zhang, Yingying Wang, Hao Wu, Tong Zhang, Guanzhi Chen, Xiaojie Huang
Summary: This study investigated factors associated with maintaining viral suppression after discontinuing antiretroviral therapy (ART). The results showed that patients who started ART during acute or early infection had longer viral control. Some broadly neutralizing HIV-1-specific antibodies were found to significantly prolong viral inhibition. Approximately 7.2% of patients achieved post-treatment control (PTC) approximately a year after discontinuation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Caixi Xi, Ang Li, Jianbo Lai, Xiaojie Huang, Peifen Zhang, Su Yan, Mengfan Jiao, Huimin Huang, Shaohua Hu
Summary: By analyzing the gut microbiota and neuroimaging characteristics in bipolar disorder (BD) patients, it was found that combining these data can lead to accurate diagnosis and prediction of quetiapine efficacy.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Multidisciplinary
Xiaojie Huang, Yunxia Xia, Da-Wei Ding
Summary: With the development of the networked society, cyber attackers pose a significant threat to complex cyber-physical networks (CCPNs). This paper investigates the synchronization of CCPNs under denial-of-service (DoS) attacks and proposes a distributed event-triggered controller to ensure synchronization without DoS attacks. An event-triggered control (ETC) strategy is also proposed to address the continuous switching of CCPNs topologies caused by DoS attacks. The effectiveness of the proposed methods is illustrated through examples.
APPLIED SCIENCES-BASEL
(2023)
Article
Immunology
Jiaojiao Liu, Benedictor Alexander Nguchu, Dan Liu, Yu Qi, Xire Aili, Shuai Han, Yuxun Gao, Xiaoxiao Wang, Hongwei Qiao, Chao Cai, Xiaojie Huang, Hongjun Li
Summary: This study used SIV-mac239-infected Chinese rhesus monkeys to investigate white matter changes and their relationships with clinical outcomes. White matter changes were detected as early as 4 weeks after inoculation, and the effects were reversed, ameliorated, or even enhanced with cART. CD4 T cell count was mainly associated with DTI metrics before cART, while the CD4/CD8 ratio was associated with white matter changes with and without cART. Viral load showed opposite associations with mean diffusivity in HIV patients with and without cART.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Han Li, Hao Peng, Wei Hong, Yingying Wei, Haojun Tian, Xiaojie Huang, Linyan Jia, Jing Zheng, Tao Duan, Qizhi He, Kai Wang
Summary: Using single-cell RNA sequencing, researchers studied the molecular characteristics of the human placenta during early pregnancy (6-16 weeks) and identified subtypes of endothelial cells and trophoblasts. They revealed the regulatory networks involved in placental development and provided a valuable resource for future research.
Review
Pharmacology & Pharmacy
Huaqing Chen, Tong Zhu, Xiaojie Huang, Wenshuang Xu, Zemin Di, Yuyang Ma, Min Xue, Sixing Bi, Yujun Shen, Yongqiang Yu, Yuxian Shen, Lijie Feng
Summary: Xanthatin inhibits glioma cell proliferation by suppressing autophagy and activating the PI3K-Akt-mTOR pathway, leading to apoptosis. This suggests that Xanthatin may be a potential therapeutic strategy against glioma.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2023)
Article
Immunology
Chao Li, Jian-Ping Sun, Ni Wang, Ping Yan, Rui Wang, Bin Su, Tong Zhang, Hao Wu, Hui Chen, Zhen Li, Xiao-Jie Huang
Summary: HIV is an immunodeficiency disease that lacks effective immune reconstruction therapies. CD4(+)T cell pyroptosis is caused by immune activation and inflammation, which cannot be reduced by antiretroviral therapy alone. CD4(+)T cell reconstitution failure can lead to coinfections. Successful immune reconstitution depends on anti-inflammatory treatment. Our experiment found that only a few cytokines could recover to normal levels after 2 years of antiretroviral treatment, consistent with the importance of HIV anti-inflammatory therapy. Early infection is associated with more severe inflammation, with certain innate immunity cytokines showing elevated levels. At least eight cytokines were found to contribute to changes in the CD4/CD8 ratio.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2023)
Article
Psychiatry
Jing Zhong, Xiao-Jie Huang, Xue-Mei Wang, Ming-Zhi Xu
Summary: This study aimed to examine whether distress tolerance mediates the relationship between stressful life events and suicide risk in patients with major depressive disorder (MDD). The study found that distress tolerance completely played a mediating role between stressful life events and suicide risk.
Article
Nutrition & Dietetics
Min Zhang, Chen Ye, Ruoyu Wang, Zongfeng Zhang, Xiaojie Huang, Mairepaiti Halimulati, Meng Sun, Yuxin Ma, Zhaofeng Zhang
Summary: This study examines the association between dietary acid load and hyperuricemia in Chinese adults. The results show that potential renal acid load is positively correlated with the prevalence of hyperuricemia, while net endogenous acid production is not significantly associated. Additionally, increased intake of fat, protein, and animal protein is linked to a higher risk of hyperuricemia.
Article
Nutrition & Dietetics
Mairepaiti Halimulati, Ruoyu Wang, Sumiya Aihemaitijiang, Xiaojie Huang, Chen Ye, Zongfeng Zhang, Lutong Li, Wenli Zhu, Zhaofeng Zhang, Lixia He
Summary: Nowadays, the development of effective intervention substances for hyperuricemia has become a public health issue. Anserine, a bioactive peptide, was found to improve liver and kidney function and modulate urate-related transporter expressions in the kidneys through a comprehensive multiomics analysis. It also showed potential in preventing and treating hyperuricemia by improving the gut-kidney axis and alleviating inflammatory responses.
Article
Nutrition & Dietetics
Ruoyu Wang, Chen Ye, Xiaojie Huang, Mairepaiti Halimulati, Meng Sun, Yuxin Ma, Rui Fan, Zhaofeng Zhang
Summary: This study aimed to investigate the interaction between a Chinese version of the Mediterranean-DASH intervention for neurodegenerative delay (cMIND) diet and indoor air pollution, and its impact on depression among older adults. The cohort study utilized data from the Chinese Longitudinal Healthy Longevity Survey from 2011-2018, including 2724 participants aged 65 and older without depression. Findings showed that severe indoor pollution and lower cMIND diet scores were associated with a higher risk of depression, suggesting that the cMIND diet may alleviate depression caused by indoor pollution among older adults.
Article
Engineering, Environmental
Xiaojie Huang, Zhouyang Long, Zhe Wang, Shuang Li, Pingbo Zhang, Yan Leng
Summary: In this study, silicon-carbon composites (Si-C-n) were designed and prepared as novel supports for nano Pt catalyst to enhance the activity and selectivity in the oxidation of glycerol to glyceric acid (GLYA). The Pt/Si-C-3 catalyst exhibited significantly enhanced glycerol conversion (74.4%) and exceptional GLYA selectivity (86.7%). The introduction of Si species in the carbon framework provided weak acid sites in Pt/Si-C-n, promoting the desorption of product GLYA, enhancing the electronic interaction between Pt and the support, and reducing the activation energy of the rate-determining step, thus contributing to high activity and selectivity towards GLYA.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Zhenya Yuan, Mu Yuan, Xuemei Song, Xiaojie Huang, Weiqiao Yan
Summary: A model combining morphokinetic and morphological characteristics, as well as clinical parameters, was developed to predict the euploidy and live birth outcomes of blastocysts in PGT for aneuploidy treatments.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)
