Article
Behavioral Sciences
Isabella Hartley, Liliana Orellana, Djin Gie Liem, Russell Keast
Summary: The aim of this study was to determine the optimal classification criterion based on the number of tests assessed to ascertain an individual's ability to discriminate between MSG and NaCl. The results showed that 24 triangle tests produced the most consistent categorization of tasters across sessions.
Review
Physiology
Jerry Yu
Summary: Multiple sensor theory (MST) explains how lung mechanosensors and cardiovascular (CV) sensors operate by detecting sensor-specific mechanical information and interacting with each other. This theory has advanced our understanding of the respiratory and CV systems, resolving numerous controversies and providing evidence for its application.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Food Science & Technology
Anjelica M. Miranda, Michael Ingram, Tiffany M. Nuessle, Stephanie A. Santorico, Nicole L. Garneau
Summary: The study investigated the impact of sourness on umami taste perception and found that increasing acidity significantly decreases the intensity of umami perception. Factors like hunger level and time since last eating also affect umami intensity perception. Biological factors such as sex, age, ancestry, and gene variation do not seem to play a role in umami perception.
FOOD QUALITY AND PREFERENCE
(2021)
Article
Physiology
Yu Lu, Jie Li, Li Dong, Ping Luo, Guohua Zhang, Weifang Rong
Summary: This study investigates the role of peripheral serotonin and its receptors in bladder physiology and pathology. The results suggest that the 5-HT4R expressed on uroepithelial cells plays an inhibitory role in bladder mechanosensory transduction. Loss of 5-HT4R-mediated inhibition may enhance bladder afferent sensitivity and exacerbate bladder overactivity in pathological conditions. Therefore, 5-HT4R agonists might be potential treatment options for overactive and painful bladder symptoms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Hrishikesh Suresh, Karim Mithani, Karanbir Brar, Han Yan, Samuel Strantzas, Mike Vandenberk, Roy Sharma, Ivanna Yau, Christina Go, Elizabeth Pang, Elizabeth Kerr, Ayako Ochi, Hiroshi Otsubo, Puneet Jain, Elizabeth Donner, O. Carter Snead, George M. Ibrahim
Summary: This study retrospectively analyzed the intraoperative data of 7 children who received vagus nerve stimulation (VNS) treatment and found a strong negative correlation between SSEP amplitude and seizure reduction, revealing the mechanism of VNS and the importance of brainstem afferent circuitry within the Vagus Afferent Network (VagAN) for seizure responsiveness following VNS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Marian Kollarik, Fei Ru, Nikoleta Pavelkova, John Mulcahy, John Hunter, Bradley J. Undem
Summary: The study found that selective Na(V)1.7 blockers can effectively inhibit the C-wave of compound action potentials and parasympathetic cholinergic contractions in human isolated bronchi. In addition, Na(V)1.7 mRNA was found to be strongly expressed and transported down the vagus nerve bundles.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Neurosciences
Valerie Y. H. van Weperen, Marmar Vaseghi
Summary: The control of cardiac sympathetic and parasympathetic tone plays a crucial role in regulating cardiac function. This control relies on sensory information transmitted from the heart to the central nervous system. The vagus nerve, which contains vagal cardiac afferent fibers, carries this sensory information to the brainstem. While vagal afferent signaling has been shown to increase parasympathetic response, it appears to change after cardiac injury, with many unknowns remaining. This review aims to summarize the current understanding of cardiac vagal afferent signaling in health and cardiovascular disease, particularly after myocardial infarction, and highlight remaining knowledge gaps.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Madina Makhmutova, Jonathan Weitz, Alejandro Tamayo, Elizabeth Pereira, Maria Boulina, Joana Almaca, Rayner Rodriguez-Diaz, Alejandro Caicedo
Summary: The study revealed the presence of vagal sensory nerve terminals in pancreatic islets, which communicate with beta-cells via serotonin signaling. Serotonin may convey information about the secretory state of beta-cells to vagal afferent nerves.
Review
Physiology
Wolfgang Langhans, Alan G. Watts, Alan C. Spector
Summary: This article discusses the cephalic phase insulin response (CPIR), which is the early release of insulin induced by head receptors during eating. The various stimuli and sensory signaling pathways that elicit CPIR are explored, as well as the efferent pathways and central integrative processes involved. The article also identifies open questions and problems with the classical CPIR definition and evaluates the physiological and clinical relevance of the cephalic contribution to insulin release.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Neurosciences
Michal Wronski, Jerzy Samochowiec, Justyna Pelka-Wysiecka, Pawel Liskiewicz, Przemyslaw Bienkowski, Blazej Misiak
Summary: This study found a possible relationship between deficit symptoms of schizophrenia and taste disturbances caused by monosodium glutamate (MSG). The intensity of taste perception was negatively correlated with the number of deficit symptoms. Clinicians should monitor and differentiate between actual taste perception deficits and taste hallucinations as symptoms of psychosis.
Article
Clinical Neurology
Kakeru Hosomoto, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Susumu Sasada, Ittetsu Kin, Ken Kuwahara, Satoshi Kawauchi, Yosuke Okazaki, Satoru Yabuno, Chiaki Sugahara, Koji Kawai, Takayuki Nagase, Shun Tanimoto, Cesario V. Borlongan, Isao Date
Summary: This study investigated the effects of continuous and selective stimulation of the vagus nerve on Parkinsonian rats. The results showed that continuous stimulation had better therapeutic effects, reducing behavioral impairments and inflammatory glial cells. Furthermore, the study highlighted the crucial role of the afferent vagal pathway in mediating these therapeutic outcomes.
Review
Neurosciences
Hui Li, Amanda J. Page
Summary: The vagus nerve is crucial in the bidirectional communication between the gut and the brain, and its dysfunction may contribute to functional dyspepsia. Understanding the alteration in vagal signaling and its pathophysiological roles may provide insights for new therapeutic treatments of this disorder.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
D. Leonardo Garcia-Ramirez, Ngoc T. Ha, Steve Bibu, Nicholas J. Stachowski, Kimberly J. Dougherty
Summary: The impact of spinal cord injury on Shox2 interneurons mainly manifests as changes in sensory afferent input pathways and modulation of Shox2 interneurons by 5-HT, enhancing excitatory responses.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Philip Hehlert, Wei Zhang, Martin C. Goepfert
Summary: Research has shown that mechanosensation in fruit flies relies on specific sensory neurons that can transduce mechanical stimuli into ionic currents and encode them into action potentials. Different channels play a role in the function of fruit fly sensory neurons, revealing similarities between fruit fly and vertebrate mechanotransduction.
TRENDS IN NEUROSCIENCES
(2021)
Article
Neurosciences
Z. Chen, D. H. Terman, S. P. Travers, J. B. Travers
Summary: Responses in the gustatory nucleus of the solitary tract (rNST) are modulated by synaptic interactions and membrane properties. The potassium current I-A is a potential modulator. This study explored the role of I-A in modulating the response to afferent stimulation and GABA-mediated inhibition in the rNST using transgenic mice expressing channelrhodopsin in GABAergic neurons.
Article
Pharmacology & Pharmacy
Farideh A. Javid, Saeed Afshin-javid, Charles C. Horn
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Review
Physiology
Charles C. Horn, Jeffrey L. Ardell, Lee E. Fisher
Article
Multidisciplinary Sciences
Ameya C. Nanivadekar, Derek M. Miller, Stephanie Fulton, Liane Wong, John Ogren, Girish Chitnis, Bryan McLaughlin, Shuyan Zhai, Lee E. Fisher, Bill J. Yates, Charles C. Horn
Article
Cell Biology
Tito Borner, Evan D. Shaulson, Misgana Y. Ghidewon, Amanda B. Barnett, Charles C. Horn, Robert P. Doyle, Harvey J. Grill, Matthew R. Hayes, Bart C. De Jonghe
Article
Endocrinology & Metabolism
Tito Borner, Evan D. Shaulson, Ian C. Tinsley, Lauren M. Stein, Charles C. Horn, Matthew R. Hayes, Robert P. Doyle, Bart C. De Jonghe
DIABETES OBESITY & METABOLISM
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Jonathan Shulgach, Ameya Nanivadekar, Derek Miller, Stephanie Fulton, Michael Sciullo, John Ogren, Liane Wong, Bryan McLaughlin, Bill Yates, Charles Horn, Lee Fisher
Meeting Abstract
Biochemistry & Molecular Biology
Jonathan Harms, Derek Miller, Jonathan Shulgach, Ameya Nanivadekar, Stephanie Fulton, Michael Sciullo, Lee Fisher, Bill Yates, Charles Horn
Article
Engineering, Biomedical
Horn C. Charles, Mats Forssell, Michael Sciullo, Jonathan E. Harms, Stephanie Fulton, Chenchen Mou, Fan Sun, Tyler W. Simpson, Gutian Xiao, Lee E. Fisher, Christopher Bettinger, Gary K. Fedder
Summary: This study demonstrates the potential for selective cervical VNS as a therapeutic approach for modulating distal nerve branches while reducing off target effects, which could potentially be refined to treat gastrointestinal, metabolic, inflammatory, cardiovascular, and respiratory diseases amenable to vagal neuromodulatory control.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Jonathan A. Shulgach, Dylan W. Beam, Ameya C. Nanivadekar, Derek M. Miller, Stephanie Fulton, Michael Sciullo, John Ogren, Liane Wong, Bryan L. McLaughlin, Bill J. Yates, Charles C. Horn, Lee E. Fisher
Summary: Vagus nerve stimulation (VNS) holds promise for affecting gastrointestinal function and treating diseases, but off-target effects can lead to major side effects. This study successfully demonstrated selective activation of vagal neurons using abdominal VNS in ferrets, and showed potential for controlling gastrointestinal function through this method.
SCIENTIFIC REPORTS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Charles P. Murphey, Jonathan A. Shulgach, Pooja R. Amin, Nerone K. Douglas, John P. Bielanin, Charles C. Horn, Bill J. Yates
Meeting Abstract
Biochemistry & Molecular Biology
Lorenzo Tomaselli, Michael Sciullo, Stephanie Fulton, Lee E. Fisher, Bill J. Yates, Valerie Ventura, Charles C. Horn
Article
Physiology
Charles P. Murphey, Jonathan A. Shulgach, Pooja R. Amin, Nerone K. Douglas, John P. Bielanin, Jacob T. Sampson, Charles C. Horn, Bill J. Yates
Summary: Nausea is difficult to distinguish in preclinical models, but based on human experience, emesis is usually preceded by nausea. The study focused on measuring gastrointestinal and cardiorespiratory changes prior to emesis to provide insights into markers for nausea. CuSO4 infusion elicited physiological changes in heart rate, respiratory rate, and intestinal electromyographic (EMG) activity, suggesting that monitoring of intestinal EMG activity, perhaps in combination with heart rate, may provide the best indicator of the onset of nausea.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Surgery
Charles C. Horn, Liane Wong, Brook S. Shepard, William F. Gourash, Bryan L. McLaughlin, Lee E. Fisher, Bestoun H. Ahmed
Summary: The study tested bioelectronic medical approaches to control vagus nerve-to-organ signaling, with findings that abdominal VNS could provide specific therapeutic control of the GI tract. However, further research is needed on electrode placement as well as device configurations and design.
JOURNAL OF SURGICAL CASE REPORTS
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Mats Forssell, Michael Sciullo, Chenchen Mou, Fan Sun, Tyler W. Simpson, Gutian Xiao, Lee E. Fisher, Christopher Bettinger, Charles C. Horn, Gary K. Fedder
Article
Neurosciences
Ragini G. Gupta, Claire Schafer, Yolande Ramaroson, Michael G. Sciullo, Charles C. Horn
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2017)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.