Review
Chemistry, Medicinal
Stephen T. Sonis
Summary: Toxicities associated with radiation therapy can be effectively mitigated through interventions aimed at disrupting the biological cascade of toxicity development, with oxidative stress being a key initiator of normal tissue injury. Attempts to supplement endogenous superoxide dismutases or develop synthetic dismutase mimetics have shown some potential, with avasopasem manganese emerging as a promising dismutase mimetic in clinical trials for reducing severe oral mucositis in head and neck cancer patients undergoing chemoradiation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Medical Laboratory Technology
Huy Anh Bach, Phuong Nhung Vu, Thi Huyen Thuong Ma, Hai Ha Nguyen, Phan Tran Duc, Duc Bui Minh, Van Hai Nong, Dang Ton Nguyen
Summary: This case-control study investigated the association of antioxidant gene polymorphisms with male infertility in Vietnamese men. The research found that the SOD1:7958GA genotype and NOS3:-786CT genotype were significantly higher in the infertility group compared to the control group, and the frequency of the SOD2:c.47TC genotype was significantly higher in the male infertility group. Gene-gene interactions between SOD1, SOD2, and CAT SNPs might increase the risk of male infertility.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Ruomei Li, Zhiyu Zhu, Bolin Zhang, Ting Jiang, Cheng Zhu, Peng Mei, Yu Jin, Ruiqing Wang, Yixin Li, Weiming Guo, Chengxiao Liu, Lunguo Xia, Bing Fang
Summary: Manganese doping is used to enhance bone regeneration by regulating adaptive immunity. It leads to increased recruitment of CD4+ T cells and promotes Th2 cell polarization while inhibiting Th1 cell polarization. This immune environment facilitates the osteogenic ability of bone marrow stromal cells and achieves consequential regeneration of mandibular bone defect.
Article
Pharmacology & Pharmacy
Fanrong Yao, Abdel A. Abdel-Rahman
Summary: The study reveals a protective role of tetrahydrobiopterin (BH4) against ethanol-induced cardiac dysfunction, and increasing BH4 levels can alleviate the adverse effects of ethanol.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
M. Dolores Garrido, Jamal El Haskouri, Maria D. Marcos, Francisco Perez-Pla, Jose Vicente Ros-Lis, Pedro Amoros
Summary: This study reports the preparation of a novel nanocomposite with enzyme-like activity for decomposing reactive oxygen species (ROS). The nanocomposite, consisting of MnOx needles covered with SiO2 porous material, was synthesized using a two-step procedure. The material was characterized, and its bimodal porosity and efficient enzyme activities were observed. The study also proposed reaction mechanisms and demonstrated the role of silica in catalase activity.
Article
Biochemistry & Molecular Biology
Talisa Doering, Justin Maire, Wing Yan Chan, Alexis Perez-Gonzalez, Luka Meyers, Rumi Sakamoto, Isini Buthgamuwa, Linda L. Blackall, Madeleine J. H. van Oppen
Summary: Coral reefs are threatened by climate change, leading to increased heatwaves and mass coral bleaching. The roles of reactive oxygen and nitrogen species in bleaching are still unclear. This study explored the effects of temperature stress on ROS and RNS production and the health of two coral models, Exaiptasia diaphana and Galaxea fascicularis. Our findings suggest that G. fascicularis is a better model for studying the cellular mechanisms of coral bleaching due to its higher levels of ROS and physiological stress compared to E. diaphana.
Review
Biochemistry & Molecular Biology
Olga-Maria Iova, Gheorghe-Eduard Marin, Izabella Lazar, Ioana Stanescu, Gabriela Dogaru, Cristina Ariadna Nicula, Adriana Elena Bulboaca
Summary: Nitric oxide, a key molecule found throughout the natural world, has a well-established role in the central nervous system and its dysregulation has been proposed as a trigger and/or aggravator for many neurological diseases. This review aims to present the main causes of pathological nitric oxide production and the important pathological mechanisms it triggers, to help explain the complex picture of neurodegenerative diseases and develop targeted therapies.
Review
Biochemistry & Molecular Biology
Xu Zhang, Depei Zhang, Li Xiang, Qiying Wang
Summary: Manganese superoxide dismutase exhibits rapid product inhibition at high temperatures but is less inhibited at lower temperatures. The temperature-dependent kinetics can be explained by changes in coordination of manganese superoxide dismutase. Cold activation of the enzyme is an adaptive response to low temperatures and plays a role in cold stress signaling and physiological responses.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Huanli Qi, Lihui Gu, Dongmei Xu, Kun Liu, Mingjie Zhou, Yu Wang, Xiujuan Wang, Yanning Li, Jinsheng Qi
Summary: This study demonstrated that 8-hydroxybutyrate promoted Cu/Zn-SOD generation, reduced peroxynitrite, and inhibited cardiac microvascular COL4 accumulation in diabetes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Visarut Buranasudja, Dolly Rani, Ashwini Malla, Khwanlada Kobtrakul, Sornkanok Vimolmangkang
Summary: Formation of oxidative stress in dermal fibroblasts is crucial for skin aging, and using phytochemicals to enhance the cells' ability to combat oxidative stress is a promising strategy to prevent skin aging. Callus culture of Centella asiatica produces unique antioxidant compounds that exhibit anti-skin-aging activities, including upregulation of cellular antioxidant enzymes and inhibition of matrix metalloprotease-9 induction. This highlights the potential of C. asiatica callus extract as an effective anti-skin-aging agent in cosmeceutical preparations.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Ken-Ichiro Tanaka, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Masahiro Kawahara, Tohru Mizushima
Summary: Lecithinized superoxide dismutase (PCSOD) effectively ameliorates renal ischemia/reperfusion (I/R) injury by inhibiting ROS production, reducing markers of renal damage and fibrosis, and preventing the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This suggests that PCSOD could be a promising therapeutic agent for I/R-induced renal injury.
Article
Biochemistry & Molecular Biology
Debbie S. Retnoningrum, Hiromi Yoshida, Ismiana Pajatiwi, Rahmat Muliadi, Ratna A. Utami, Anita Artarini, Wangsa T. Ismaya
Summary: The manganese superoxide dismutase from Staphylococcus equorum (MnSODSeq) has shown robust activity under various conditions. Strengthening the interactions between the monomers is crucial for improving the enzyme stability. A new strategy using K38R-A121E/Y double substitutions has been proposed, resulting in mutants with similar enzyme activity and enhanced thermal stability. The structure of the L169W mutant was also elucidated, revealing the impact of intramolecular modification on enzyme stability.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biology
Lucie Gerber, Kathy A. Clow, Anthony K. Gamperl
Summary: Acclimation to 20 degrees Celsius can protect the cardiac mitochondrial function of Atlantic salmon, decrease ROS production, and improve membrane integrity, but the plasticity may be limited when combined with other stressors.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Oncology
Merce Juliachs, Mireia Pujals, Chiara Bellio, Nathalie Meo-Evoli, Juan M. Duran, Esther Zamora, Mireia Pares, Anna Sunol, Olga Mendez, Alex Sanchez-Pla, Francesc Canals, Cristina Saura, Josep Villanueva
Summary: This study aims to find circulating biomarkers for monitoring the response to cancer therapy. The research found that the release of SOD2 protein during chemotherapy treatment is associated with tumor cell death, and the increase in its circulating levels correlates with treatment response, which can be used for non-invasive monitoring of breast cancer patients.
Article
Chemistry, Multidisciplinary
Fang Yuan, Cuiling Zhang, Xianzhu Luo, Xiaokun Shen, Yuezhong Xian
Summary: ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.
CHEMICAL COMMUNICATIONS
(2023)
Article
Critical Care Medicine
Raimund Helbok, Jed A. Hartings, Alois Schiefecker, Baptiste Balanca, Sharon Jewel, Brandon Foreman, Ari Ercole, Ramani Balu, Cenk Ayata, Laura Ngwenya, Eric Rosenthal, Martyn G. Boutelle, Eszter Farkas, Jens P. Dreier, Martin Fabricius, C. William Shuttleworth, Andrew Carlson
NEUROCRITICAL CARE
(2020)
Article
Endocrinology & Metabolism
Daniel P. Varga, Akos Menyhart, Balazs Posfai, Eszter Csaszar, Nikolett Lenart, Csaba Cserep, Barbara Orsolits, Bernadett Martinecz, Tamers Szlepak, Ferenc Bari, Eszter Farka, Adam Denes
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Neurosciences
Orsolya M. Toth, Akos Menyhart, Viktoria Eva Varga, Dora Hantosi, Orsolya Ivankovits-Kiss, Daniel Peter Varga, Irisz Szabo, Laszlo Janovak, Imre Dekany, Eszter Farkas, Ferenc Bari
Article
Neurosciences
Rita Frank, Ferenc Bari, Akos Menyhart, Eszter Farkas
Summary: Research on live rat brain slices has shown that severe osmotic stress or oxygen-glucose deprivation can induce SD. In contrast with SDs triggered in normal medium, those occurring under oxygen-glucose deprivation or hypo-osmotic conditions are characterized by incomplete repolarization and prolonged duration.
Article
Biochemistry & Molecular Biology
Reka Toth, Attila E. Farkas, Istvan A. Krizbai, Peter Makra, Ferenc Bari, Eszter Farkas, Akos Menyhart
Summary: This study reveals the presence of post-SD astrocyte Ca2+ oscillations in the mouse somatosensory cortex, occurring minutes after the Ca2+ wave of SD and involving fewer astrocytes compared to the Ca2+ waves. Additionally, the data confirms the correlation between astrocyte Ca2+ waves and arteriolar constriction, while post-SD Ca2+ oscillations coincide with the peak of the SD-related vasodilation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Akos Menyhart, Rita Frank, Attila E. Farkas, Zoltan Sule, Viktoria E. Varga, Adam Nyul-Toth, Anne Meiller, Orsolya Ivankovits-Kiss, Coline L. Lemale, Irisz Szabo, Reka Toth, Daniel Zolei-Szenasi, Johannes Woitzik, Stephane Marinesco, Istvan A. Krizbai, Ferenc Bari, Jens P. Dreier, Eszter Farkas
Summary: Acute brain swelling impairs astroglial glutamate clearance and leads to extracellular glutamate accumulation and the occurrence of SiD, a pathological spreading depolarization associated with astrocyte swelling and neuronal death. Preventive osmotherapy may be necessary in acute brain injury to mitigate the effects of SiD.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Irisz Szabo, Viktoria E. Varga, Szabolcs Dvoracsko, Attila E. Farkas, Timea Kormoczi, Robert Berkecz, Szilvia Kecskes, Akos Menyhart, Rita Frank, Dora Hantosi, Nicholas V. Cozzi, Ede Frecska, Csaba Tomboly, Istvan A. Krizbai, Ferenc Bari, Eszter Farkas
Summary: The study suggests that DMT may serve as an adjuvant pharmacological therapy in the management of acute cerebral ischemia, by mitigating spreading depolarizations (SDs) and promoting neuronal survival, reducing the number of apoptotic and ferroptotic cells.
Article
Polymer Science
Mohamed M. Abdelghafour, Agoston Orban, Agota Deak, Lukasz Lamch, Eva Frank, Roland Nagy, Adel Adam, Pal Sipos, Eszter Farkas, Ferenc Bari, Laszlo Janovak
Summary: Poly(ethylene succinate) (PES) is a promising biodegradable and biocompatible polyester used in various biomedical applications. Through systematic synthesis and purification methods, PES with different molecular weights can be obtained, making it a potential candidate for biomedical applications. The reported data and constants from the study are valuable for researchers working with this promising polyester.
Article
Critical Care Medicine
Akos Menyhart, Daniel Peter Varga, Orsolya M. Toth, Peter Makra, Ferenc Bari, Eszter Farkas
Summary: The study investigates the interplay between impaired cerebrovascular autoregulation, SD occurrence, and the evolution of the SD-coupled CBF response in acute brain injury, suggesting dysfunction of autoregulation poses a risk of SD occurrence and damages neurovascular coupling.
NEUROCRITICAL CARE
(2022)
Article
Immunology
Eszter Csaszar, Nikolett Lenart, Csaba Cserep, Zsuzsanna Koernyei, Rebeka Fekete, Balazs Posfai, Diana Balazsfi, Balazs Hangya, Anett D. Schwarcz, Eszter Szabadits, David Szoellosi, Krisztian Szigeti, Domokos Mathe, Brian L. West, Katalin Sviatko, Ana Rita Bras, Jean-Charles Mariani, Andrea Kliewer, Zsolt Lenkei, Laszlo Hricisak, Zoltan Benyo, Maria Baranyi, Beata Sperlagh, Akos Menyhart, Eszter Farkas, Adam Denes
Summary: Microglia play an important role in cerebral blood flow regulation through complex purinergic actions, which are mediated by dynamic interactions with the vasculature and are partially independent of nitric oxide. This study reveals a previously unrecognized role for microglia in regulating cerebral blood flow and has broad implications for common neurological diseases.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Critical Care Medicine
R. David Andrew, Eszter Farkas, Jed A. Hartings, K. C. Brennan, Oscar Herreras, Michael Mueller, Sergei. A. Kirov, Cenk Ayata, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, Ken D. Dawson-Scully, Ghanim Ullah, Jens P. Dreier
Summary: The spreading depolarizations (SD) theory provides a better explanation for acute neuronal injury caused by brain ischemia than the theory of excessive glutamate release. The challenges in developing therapeutic strategies based on more informed basic science are highlighted, calling for a shift in focus towards understanding the molecular biology of SD initiation and propagation.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
R. David Andrew, Jed A. Hartings, Cenk Ayata, K. C. Brennan, Ken D. Dawson-Scully, Eszter Farkas, Oscar Herreras, Sergei A. Kirov, Michael Muller, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, C. William Shuttleworth, Ghanim Ullah, Jens P. Dreier
Summary: In this review, the mechanism and impact of spreading depolarization (SD) in the gray matter following blood flow loss are discussed. The initiation and propagation of SD are explored, along with the challenges and pitfalls in studying SD. The review concludes with a summary of the research direction and ongoing debates regarding SD.
NEUROCRITICAL CARE
(2022)
Article
Endocrinology & Metabolism
Anna Toerteli, Reka Toth, Sarah Berger, Sarah Samardzic, Ferenc Bari, Akos Menyhart, Eszter Farkas
Summary: Despite successful recanalization, reperfusion failure associated with poor neurological outcomes develops in half of treated stroke patients. We explore here whether spreading depolarization (SD) is a predictor of reperfusion failure.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Akos Menyhart, Armand Rafael Balint, Peter Kozak, Ferenc Bari, Eszter Farkas
Summary: This study investigated the progressive restoration of impaired neurovascular coupling and the effect of nimodipine treatment after cerebral oligemia. The results showed that nimodipine accelerated the recovery of cerebral blood flow and functional hyperemia after oligemia, suggesting its potential use in migraine prophylaxis.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Szilvia Kecskes, Akos Menyhart, Ferenc Bari, Eszter Farkas
Summary: This study discovered a decline in cerebrovascular reactivity (CVR) and cellular senescence in the brains of old rats. Additionally, CVR impairment was observed in acute cerebral ischemia. The use of nimodipine showed mixed effects, improving CVR in aging brains but worsening it in acute ischemia.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.