Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci

Comparative analysis of spreading depolarizations in brain slices exposed to osmotic or metabolic stress

(2021) Rita Frank et al.   BMC NEUROSCIENCE

Cerebrospinal fluid influx drives acute ischemic tissue swelling

(2020) Humberto Mestre et al.   SCIENCE

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

(2020) Nathalie Percie du Sert et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lessons from the CONSCIOUS-1 Study

(2020) Alexander J. Schupper et al.   Journal of Clinical Medicine

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

(2019) Shaimaa Mahmoud et al.   Cells

Metabolic constraints of swelling‐activated glutamate release in astrocytes and their implication for ischemic tissue damage

(2019) Corinne S. Wilson et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate-Releasing SWELL1 Channel in Astrocytes Modulates Synaptic Transmission and Promotes Brain Damage in Stroke

(2019) Junhua Yang et al.   NEURON

Terminal spreading depolarization and electrical silence in death of human cerebral cortex

(2018) Jens P. Dreier et al.   ANNALS OF NEUROLOGY

The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex

(2018) Janos Lückl et al.   BRAIN

Systematic review of the pharmacological agents that have been tested against spreading depolarizations

(2018) Anna Klass et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spreading depolarization is not an epiphenomenon but the principal mechanism of the cytotoxic edema in various gray matter structures of the brain during stroke

(2018) Jens P. Dreier et al.   NEUROPHARMACOLOGY

Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization

(2018) Ákos Menyhárt et al.   NEUROBIOLOGY OF DISEASE

Pathophysiology and treatment of cerebral edema in traumatic brain injury

(2018) Ruchira M. Jha et al.   NEUROPHARMACOLOGY

Astrocytes drive cortical vasodilatory signaling by activating endothelial NMDA receptors

(2017) Lingling Lu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Advancing age and ischemia elevate the electric threshold to elicit spreading depolarization in the cerebral cortex of young adult rats

(2016) Péter Hertelendy et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

(2016) Jens P Dreier et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy

(2016) Jed A Hartings et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition

(2016) Nancy Carney et al.   NEUROSURGERY

Dynamics of Ionic Shifts in Cortical Spreading Depression

(2015) Rune Enger et al.   CEREBRAL CORTEX

Molecular pathophysiology of cerebral edema

(2015) Jesse A Stokum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cell swelling increases the severity of spreading depression in Locusta migratoria

(2015) Kristin E. Spong et al.   JOURNAL OF NEUROPHYSIOLOGY

Consistent and reproducible staining of glia by a modified Golgi–Cox method

(2015) S. Gull et al.   JOURNAL OF NEUROSCIENCE METHODS

Supply-Demand Mismatch Transients in Susceptible Peri-infarct Hot Zones Explain the Origins of Spreading Injury Depolarizations

(2015) Daniel von Bornstädt et al.   NEURON

The Stroke-Migraine Depolarization Continuum

(2015) Jens P. Dreier et al.   NEURON

Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance

(2014) Jessica L. Seidel et al.   GLIA

Imaging Reveals the Focal Area of Spreading Depolarizations and a Variety of Hemodynamic Responses in a Rat Microembolic Stroke Model

(2014) Zsófia Bere et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Minimum conditions for the induction of cortical spreading depression in brain slices

(2014) Yujie T. Tang et al.   JOURNAL OF NEUROPHYSIOLOGY

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Immobilization Method to Preserve Enzyme Specificity in Biosensors: Consequences for Brain Glutamate Detection

(2013) Natalia Vasylieva et al.   ANALYTICAL CHEMISTRY

Persistent astroglial swelling accompanies rapid reversible dendritic injury during stroke-induced spreading depolarizations

(2012) W. Christopher Risher et al.   GLIA

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

(2010) Martin Lauritzen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

The Na–K–Cl Co-transporter in astrocyte swelling

(2010) Arumugam R. Jayakumar et al.   METABOLIC BRAIN DISEASE

Multi-modal imaging of anoxic depolarization and hemodynamic changes induced by cardiac arrest in the rat cerebral cortex

(2010) Eszter Farkas et al.   NEUROIMAGE

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

(2010) Hironaka Igarashi et al.   NEUROLOGICAL SCIENCES

Real-time passive volume responses of astrocytes to acute osmotic and ischemic stress in cortical slices andin vivorevealed by two-photon microscopy

(2008) W. Christopher Risher et al.   GLIA