β-Hydroxybutyrate inhibits cardiac microvascular collagen 4 accumulation by attenuating oxidative stress in streptozotocin-induced diabetic rats and high glucose treated cells

Why a d-β-hydroxybutyrate monoester?

(2020) Adrian Soto-Mota et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Insulin resistance and heart failure during treatment with sodium glucose cotransporter 2 inhibitors: proposed role of ketone utilization

(2020) Yoshiyuki Hattori   HEART FAILURE REVIEWS

Osteopontin up-regulates Col IV expression through repressing miR-29a in human retinal capillary endothelial cells

(2020) Ping Duan et al.   Molecular Therapy-Nucleic Acids

Cinnamaldehyde Ameliorates Vascular Dysfunction in Diabetic Mice by Activating Nrf2

(2020) Peijian Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

β-hydroxybutyrate and its metabolic effects on age-associated pathology

(2020) Young-Min Han et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Up-regulation of MMP-2 by histone H3K9 β-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat

(2020) Weigang Luo et al.   ACTA DIABETOLOGICA

Cardiac ketone body metabolism

(2020) Azrul Abdul Kadir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

β-hydroxybutyrate antagonizes aortic endothelial injury by promoting generation of VEGF in diabetic rats

(2020) Xingliang Wu et al.   TISSUE & CELL

Heart Failure with Preserved Ejection Fraction—a Concise Review

(2020) Daria M. Adamczak et al.   Current Cardiology Reports

Role of AMP-activated protein kinase on cardio-metabolic abnormalities in the development of diabetic cardiomyopathy: A molecular landscape

(2020) Abdul Haye et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome

(2019) Maria Consiglia Trotta et al.   PLoS One

Canagliflozin, an SGLT2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats

(2019) Yukishige Kimura et al.   Journal of Diabetes Investigation

Cardiovascular Effects of Treatment with the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients

(2019) Roni Nielsen et al.   CIRCULATION

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

(2019) Chia-Wei Cheng et al.   CELL

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

(2019) Slaven Stekovic et al.   Cell Metabolism

β-Hydroxybutyrate Ameliorates Aβ-Induced Downregulation of TrkA Expression by Inhibiting HDAC1/3 in SH-SY5Y Cells

(2019) Xinhui Li et al.   American Journal of Alzheimers Disease and Other Dementias

Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes

(2019) Nicole Jacqueline Jensen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Do most patients with obesity or type 2 diabetes, and atrial fibrillation, also have undiagnosed heart failure? A critical conceptual framework for understanding mechanisms and improving diagnosis and treatment

(2019) Milton Packer   EUROPEAN JOURNAL OF HEART FAILURE

Safety and tolerability of sustained exogenous ketosis using ketone monoester drinks for 28 days in healthy adults

(2019) Adrian Soto-Mota et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

C-peptide prevents SMAD3 binding to alpha promoters to inhibit collagen type IV synthesis

(2018) Yanning Li et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

(2018) Maayan Waldman et al.   Cardiovascular Diabetology

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

(2018) Young-min Han et al.   MOLECULAR CELL

The copper-zinc superoxide dismutase activity in selected diseases

(2018) Łukasz Lewandowski et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

(2018) Saroj Chakraborty et al.   Cell Reports

Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting

(2017) Adam J Wilson et al.   HEART

Ketone bodies mimic the life span extending properties of caloric restriction

(2017) Richard L. Veech et al.   IUBMB LIFE

Ketogenic Metabolism Inhibits Histone Deacetylase (HDAC) and Reduces Oxidative Stress After Spinal Cord Injury in Rats

(2017) Xiaomeng Wang et al.   NEUROSCIENCE

On the Metabolism of Exogenous Ketones in Humans

(2017) Brianna J. Stubbs et al.   Frontiers in Physiology

β-Hydroxybutyrate: A signaling metabolite in starvation response?

(2016) Pedro Rojas-Morales et al.   CELLULAR SIGNALLING

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Effect of Hyperketonemia (Acetoacetate) on Nuclear Factor-κB and p38 Mitogen-Activated Protein Kinase Activation Mediated Intercellular Adhesion Molecule 1 Upregulation in Endothelial Cells

(2015) Justin L. Rains et al.   Metabolic Syndrome and Related Disorders

Protein nitration promotes inducible nitric oxide synthase transcription mediated by NF-κB in high glucose-stimulated human lens epithelial cells

(2013) Yanning Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY