Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Gogola, Davneet S. Minhas, Victor L. Villemagne, Ann D. Cohen, James M. Mountz, Tharick A. Pascoal, Charles M. Laymon, N. Scott Mason, Milos D. Ikonomovic, Chester A. Mathis, Beth E. Snitz, Oscar L. Lopez, William E. Klunk, Brian J. Lopresti
Summary: This study compared the characteristics of two frequently used tau PET tracers, F-18-flortaucipir and F-18-MK-6240, in the same subjects. The results showed that both tracers performed equally well in visual interpretations and were capable of quantifying signal in a common set of brain regions that develop tau pathology in Alzheimer disease. However, they also showed distinct patterns of apparent off-target binding, and F-18-MK-6240 exhibited a greater dynamic range in SUVR estimates.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Yunze Wang, Qingyu Lin, Hongcheng Shi, Dengfeng Cheng
Summary: Positron emission tomography (PET) molecular imaging technology is a critical tool for evaluating biological and biochemical processes. Fluorine-18 has favorable characteristics for labeling and molecular imaging, making it significant in radiochemistry and radiopharmaceutics. The development of new reagents and catalysts has led to rapid growth in F-18 labeling methods over the past decades.
FRONTIERS IN CHEMISTRY
(2022)
Article
Medicine, General & Internal
Hyun Jin Yoon, Kook Cho, Woong Gon Kim, Young-Jin Jeong, Ji-Eun Jeong, Do-Young Kang
Summary: This study aimed to evaluate heterogeneity indices of F-18 FP-CIT PET images in Parkinson's disease (PD) diagnosis and assess diagnostic accuracy using machine learning (ML). After calculating 108 indices, dimensional reduction to 71 dimensions using PCA allowed for 91.3% accurate classification. Machine learning methods such as logistic regression, support vector machine, random forest, and eXtreme Gradient Boosting were used, with the latter achieving a classification accuracy of 95.7%.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Weicheng Zhou, Jinju Sun, Fangyang Wang, Yi Wang, Xiao Chen
Summary: We presented cardiac F-18-FAPI PET/CT findings in 3 cases with myocarditis of varying duration. Different F-18-FAPI uptake was observed in myocarditis with different symptom durations, indicating the potential of F-18-FAPI PET/CT in evaluating fibrosis extent caused by myocarditis. This information may guide treatment decisions for patients with myocarditis.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniela-Elena Oprea-Lager, Eric Gontier, Lina Garcia-Canamaque, Mathieu Gauthe, Pierre Olivier, Mercedes Mitjavila, Pilar Tamayo, Philippe Robin, Ana Maria Garcia Vicente, Anne-Charlotte Bouyeure, Alban Bailliez, Antonio Rodriguez-Fernandez, Sinan Ben Mahmoud, Juan Antonio Vallejo-Casas, Philippe Maksud, Charles Merlin, Paul Blanc-Durand, Clement Drouet, Hubert Tissot, Irina Vierasu, Thierry Vander Borght, Evelyne Boos, Florence Chossat, Marina Hodolic, Caroline Rousseau
Summary: The purpose of this study was to compare the per-patient detection rates of [F-18]DCFPyL and [F-18]fluoromethylcholine PET/CT in patients with first prostate cancer biochemical recurrence. The results showed that [F-18]DCFPyL had a significantly higher detection rate compared to [F-18]fluoromethylcholine.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Hongkai Wang, Yang Tian, Yang Liu, Zhaofeng Chen, Haoyu Zhai, Mingrui Zhuang, Nan Zhang, Yuanfang Jiang, Ya Gao, Hongbo Feng, Yanjun Zhang
Summary: The study enriched the family of publicly available brain PET templates by developing Chinese-specific template images based on [F-18]-FDG PET images of normal participants. The templates were validated through SPM analysis of Alzheimer's and Parkinson's patient images, accurately depicting disease-related brain regions with abnormal [F-18]-FDG uptake. The SPM analysis programmes developed also facilitated easy use of the templates, proving their effectiveness in brain function impairment analysis.
Article
Oncology
Yachao Liu, Hongkai Yu, Jiajin Liu, Xiaojun Zhang, Mu Lin, Holger Schmidt, Jiangping Gao, Baixuan Xu
Summary: This study demonstrated that F-18-DCFPyL PET/CT-US or PET/MRI-US fusion targeted prostate biopsies may be valuable for prostate cancer diagnosis, with a high detection rate of clinically significant prostate cancer for PET-positive lesions. PET/MR can help rule out false PET-positive lesions, potentially reducing unnecessary prostate biopsies.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Behavioral Sciences
Ruiqing Ni
Summary: Animal models of α-synucleinopathies have greatly contributed to the understanding of the disease and the development of therapeutics. Recent advances in positron emission tomography have allowed the noninvasive visualization of molecular alterations and behavioral dysfunctions in these animal models. This review focuses on the development of new PET tracers and studies of α-synuclein and neurotransmitter receptor deficits in Parkinson's disease animal models.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jessie Fanglu Fu, Cristina Lois, Justin Sanchez, J. Alex Becker, Zoe B. Rubinstein, Emma Thibault, Andrew N. Salvatore, Hasan Sari, Michelle E. Farrell, Nicolas J. Guehl, Marc D. Normandin, Georges El Fakhri, Keith A. Johnson, Julie C. Price
Summary: This study investigated the kinetics and longitudinal changes of [F-18]MK-6240 PET in cognitively-normal and cognitively-impaired subjects. The results suggest that eroded cerebral white matter or pons may be preferred for longitudinal studies, while eroded cerebellar gray matter showed larger cross-sectional effect sizes for group differentiation. The study also found high variability in extracerebral signal, which exhibited irreversible kinetics and nonsignificant longitudinal changes with high individual variability.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Dieter Waschbuesch, Nicole Huebel, Edith Ossendorf, Evy Lobbestael, Veerle Baekelandt, Andrew J. Lindsay, Mary W. McCaffrey, Amir R. Khan, Angelika Barnekow
Article
Biology
Zhiling Li, Marlene M. Hao, Chris Van den Haute, Veerle Baekelandt, Werend Boesmans, Pieter Vanden Berghe
Article
Biochemistry & Molecular Biology
Francesco Fabbrini, Chris Van den Haute, Marina De Vitis, Veerle Baekelandt, Wim Vanduffel, Rufin Vogels
Article
Multidisciplinary Sciences
Sarah van Veen, Shaun Martin, Chris Van den Haute, Veronick Benoy, Joseph Lyons, Roeland Vanhoutte, Jan Pascal Kahler, Jean-Paul Decuypere, Geraldine Gelders, Eric Lambie, Jeffrey Zielich, Johannes V. Swinnen, Wim Annaert, Patrizia Agostinis, Bart Ghesquiere, Steven Verhelst, Veerle Baekelandt, Jan Eggermont, Peter Vangheluwe
Article
Multidisciplinary Sciences
Evelien Houben, Kris Janssens, Doryssa Hermans, Jennifer Vandooren, Chris Van den Haute, Melissa Schepers, Tim Vanmierlo, Ivo Lambrichts, Jack van Horssen, Veerle Baekelandt, Ghislain Opdenakker, Wia Baron, Bieke Broux, Helena Slaets, Niels Hellings
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Neurosciences
Latoya Stevens, Kristl Vonck, Lars Emil Larsen, Wouter Van Lysebettens, Charlotte Germonpre, Veerle Baekelandt, Chris Van den Haute, Evelien Carrette, Wytse Jan Wadman, Paul Boon, Robrecht Raedt
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Clinical Neurology
Anke Van der Perren, Geraldine Gelders, Alexis Fenyi, Luc Bousset, Filipa Brit, Wouter Peelaerts, Chris Van den Haute, Steve Gentleman, Ronald Melki, Veerle Baekelandt
ACTA NEUROPATHOLOGICA
(2020)
Article
Clinical Neurology
Shaun Martin, Stefanie Smolders, Chris Van den Haute, Bavo Heeman, Sarah van Veen, David Crosiers, Igor Beletchi, Aline Verstraeten, Helena Gossye, Geraldine Gelders, Philippe Pals, Norin Nabil Hamouda, Sebastiaan Engelborghs, Jean-Jacques Martin, Jan Eggermont, Peter Paul De Deyn, Patrick Cras, Veerle Baekelandt, Peter Vangheluwe, Christine Van Broeckhoven
ACTA NEUROPATHOLOGICA
(2020)
Review
Neurosciences
Diego Cabezudo, Veerle Baekelandt, Evy Lobbestael
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Cell Biology
Julia Obergasteiger, Giulia Frapporti, Giulia Lamonaca, Sara Pizzi, Anne Picard, Alexandros A. Lavdas, Francesca Pischedda, Giovanni Piccoli, Sabine Hilfiker, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Corrado Corti, Peter P. Pramstaller, Mattia Volta
CELL DEATH DISCOVERY
(2020)
Article
Chemistry, Physical
Evelien De Meulenaere, Yovan de Coene, Isabelle Russier-Antoine, Louis Vanpraet, Chris Van den Haute, Karin Thevissen, Veerle Baekelandt, Carmen Bartic, Johan Hofkens, Pierre-Francois Brevet, Koen Clays
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2020)
Article
Clinical Neurology
Diego Cabezudo, George Tsafaras, Eva Van Acker, Chris Van den Haute, Veerle Baekelandt
Summary: This study provides evidence for the central role of LRRK2 protein in gut inflammation and Parkinson's disease. The G2019S mutation in LRRK2 increases inflammatory response and disease phenotype. The study also shows that gut inflammation can impact brain homeostasis and contribute to neurodegeneration in Parkinson's disease.
ACTA NEUROPATHOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
Norin Nabil Hamouda, Chris Van den Haute, Roeland Vanhoutte, Ragna Sannerud, Mujahid Azfar, Rupert Mayer, Alvaro Cortes Calabuig, Johannes Swinnen, Patrizia Agostinis, Veerle Baekelandt, Wim Annaert, Francis Impens, Steven H. L. Verhelst, Jan Eggermont, Shaun Martin, Peter Vangheluwe
Summary: By genome sequencing, researchers identified a new component of the mammalian polyamine transport system, ATP13A3, which is closely associated with polyamine uptake and sensitivity to MGBG toxicity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Meeting Abstract
Clinical Neurology
S. Smolders, S. Martin, C. Van Den Haute, B. Heeman, S. Van Veen, D. Crosiers, I. Beletchi, A. Verstraeten, H. Gossye, G. Gelders, P. Pals, N. Hamouda, S. Engelborghs, J. -J. Martin, J. Eggermont, P. P. De Deyn, P. Cras, V. Baekelandt, P. Vangheluwe, C. Van Broeckhoven, B. Consortium
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Meeting Abstract
Ophthalmology
Lien Veys, Marjan Vandenabeele, Veerle Baekelandt, Lieve K. M. Moons, Lies De Groef
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
