Article
Multidisciplinary Sciences
Katie L. Ayers, Stefanie Eggers, Ben N. Rollo, Katherine R. Smith, Nadia M. Davidson, Nicole A. Siddall, Liang Zhao, Josephine Bowles, Karin Weiss, Ginevra Zanni, Lydie Burglen, Shay Ben-Shachar, Jenny Rosensaft, Annick Raas-Rothschild, Anne Jorgensen, Ralf B. Schittenhelm, Cheng Huang, Gorjana Robevska, Jocelyn van den Bergen, Franca Casagranda, Justyna Cyza, Svenja Pachernegg, David K. Wright, Melanie Bahlo, Alicia Oshlack, Terrence J. O'Brien, Patrick Kwan, Peter Koopman, Gary R. Hime, Nadine Girard, Chen Hoffmann, Yuval Shilon, Amnon Zung, Enrico Bertini, Mathieu Milh, Bochra Ben Rhouma, Neila Belguith, Anu Bashamboo, Kenneth MacElreavey, Ehud Banne, Naomi Weintrob, Bruria BenZeev, Andrew H. Sinclair
Summary: The study identifies recessive variants in the SART3 gene in individuals with intellectual disability, global developmental delay, brain anomalies, and gonadal dysgenesis. Functional experiments reveal the role of SART3 in testicular and neuronal development. The findings suggest a new spliceosomopathy syndrome (INDYGON syndrome) and offer potential for improved diagnosis and treatment.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Katie L. Ayers, Stefanie Eggers, Ben N. Rollo, Katherine R. Smith, Nadia M. Davidson, Nicole A. Siddall, Liang Zhao, Josephine Bowles, Karin Weiss, Ginevra Zanni, Lydie Burglen, Shay Ben-Shachar, Jenny Rosensaft, Annick Raas-Rothschild, Anne Jorgensen, Ralf B. Schittenhelm, Cheng Huang, Gorjana Robevska, Jocelyn van den Bergen, Franca Casagranda, Justyna Cyza, Svenja Pachernegg, David K. Wright, Melanie Bahlo, Alicia Oshlack, Terrence J. O'Brien, Patrick Kwan, Peter Koopman, Gary R. Hime, Nadine Girard, Chen Hoffmann, Yuval Shilon, Amnon Zung, Enrico Bertini, Mathieu Milh, Bochra Ben Rhouma, Neila Belguith, Anu Bashamboo, Kenneth McElreavey, Ehud Banne, Naomi Weintrob, Bruria BenZeev, Andrew H. Sinclair
Summary: We identified recessive variants in SART3 gene in individuals with intellectual disability, global developmental delay, brain anomalies, and gonadal dysgenesis. Further research in fruit flies and human induced pluripotent stem cells revealed the conserved role of SART3 in testicular and neuronal development, and disruption of signaling pathways and abnormal gonadal and neuronal differentiation caused by SART3 variants. These findings suggest that SART3 variants may cause a spliceosomopathy named INDYGON syndrome and contribute to improved diagnoses and outcomes for affected individuals.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Tom T. Fischer, Lien D. Nguyen, Barbara E. Ehrlich
Summary: The study revealed that the absence of NCS1 in the brain leads to reduced dendritic complexity and spine density, which may be associated with deficits in memory acquisition. RNA sequencing results showed that NCS1 modulates gene expression related to neuronal morphology and development.
Article
Cell Biology
Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Constanze Depp, Andrew O. Sasmita, Martina H. Vasileva, Patricia Scholz, Yu Zhao, Dilja Krueger-Burg, Sven Wichert, Euan R. Brown, Kyriakos Michail, Klaus-Armin Nave, Stefan Bonn, Francesca Odoardi, Moritz Rossner, Till Ischebeck, Julia M. Edgar, Gesine Saher
Summary: Research has shown that in chronic demyelinating diseases, increased neuronal cholesterol synthesis plays a critical role in remyelination, especially when lipid recycling is defective in the affected area. This finding contributes to understanding disease progression and has implications for therapeutic strategies in patients with multiple sclerosis (MS).
Article
Cell Biology
Natasha M. O'Brown, Nikit B. Patel, Ursula Hartmann, Allon M. Klein, Chenghua Gu, Sean G. Megason
Summary: This study identifies Spock1 as a neuronal signal for regulating BBB permeability, which alters the ECM to regulate pericyte-endothelial interactions and downstream vascular gene expression.
DEVELOPMENTAL CELL
(2023)
Article
Agriculture, Dairy & Animal Science
Victoria Anthony Uyanga, Semiu Folaniyi Bello, Xin Qian, Ning Chao, Haifang Li, Jingpeng Zhao, Xiaojuan Wang, Hongchao Jiao, Okanlawon M. Onagbesan, Hai Lin
Summary: High ambient temperature is a major stressor for poultry production, and nutritional interventions involving amino acids have been used to combat thermal stress. This study aimed to investigate the effects of L-citrulline supplementation on gene expression in the hypothalamus of chickens raised under different ambient temperatures. The results showed that L-citrulline can influence gene transcripts associated with brain development, feeding behavior, energy metabolism, and thermoregulation in chickens.
Article
Multidisciplinary Sciences
Mehmet Neset ozel, Felix Simon, Shadi Jafari, Isabel Holguera, Yen-Chung Chen, Najate Benhra, Rana Naja El-Danaf, Katarina Kapuralin, Jennifer Amy Malin, Nikolaos Konstantinides, Claude Desplan
Summary: Deciphering neuronal diversity in the Drosophila optic lobe during pupal development reveals transient extrinsic neurons and dorsoventral asymmetry in visual circuits.
Article
Biochemistry & Molecular Biology
Peter Engerer, Eleni Petridou, Philip R. Williams, Sachihiro C. Suzuki, Takeshi Yoshimatsu, Ruben Portugues, Thomas Misgeld, Leanne Godinho
Summary: Studies have shown spontaneous neuronal fate re-specification in the zebrafish retina, challenging the traditional view of neuronal identity as immutable. This unexpected plasticity in cell fate during retinal development suggests that post-mitotic neurons can switch their identity, highlighting a new aspect of neural development.
Article
Cell Biology
Hanseul Kweon, Won Beom Jung, Geun Ho Im, Jia Ryoo, Joon-Hyuk Lee, Hogyeong Do, Yeonsoo Choi, You-Hyang Song, Hwajin Jung, Haram Park, Lily R. Qiu, Jacob Ellegood, Hyun-Ji Shim, Esther Yang, Hyun Kim, Jason P. Lerch, Seung-Hee Lee, Won-Suk Chung, Daesoo Kim, Seong-Gi Kim, Eunjoon Kim
Summary: Deletion of the CHD8 gene in mice leads to near-complete elimination of neocortical structures, yet the mice display mostly normal behaviors, including hyperactivity and increased social interaction. These changes are accompanied by thalamic hyperactivity and enhanced somatosensory function, suggesting a critical role of excitatory neuronal CHD8 in neurodevelopment and a compensatory response in CHD8 haploinsufficiency-related macrocephaly.
Article
Anatomy & Morphology
Edith Sanchez-Jaramillo, Gabor Wittmann, Judit Menyhert, Praful Singru, Gabriela B. Gomez-Gonzalez, Eduardo Sanchez-Islas, Nashiely Yanez-Recendis, Jaime Arturo Pimentel-Cabrera, Martha Leon-Olea, Balazs Gereben, Csaba Fekete, Jean-Louis Charli, Ronald M. Lechan
Summary: This study reveals the role of hypothalamic TRH neurons in regulating energy homeostasis through their projection to the tuberomammillary nucleus, which may be mediated by influencing histamine neurons.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Cell & Tissue Engineering
Kyungtae Lim, Alex P. A. Donovan, Walfred Tang, Dawei Sun, Peng He, J. Patrick Pett, Sarah A. Teichmann, John C. Marioni, Kerstin B. Meyer, Andrea H. Brand, Emma L. Rawlins
Summary: Variation in lung alveolar development is linked to disease susceptibility. Researchers have identified an alveolar-fated epithelial progenitor in human fetal lungs and have grown them as self-organizing organoids to study cell lineage commitment. Using this system, they have discovered the role of Wnt signaling and the Wnt-NKX2.1 axis in alveolar differentiation, as well as the effects of genetic variation on this process.
Article
Cell Biology
Joohyung Kim, Sungdae Kim, Minyeop Nahm, Tsai-Ning Li, Hsin-Chieh Lin, Yeongjin David Kim, Jihye Lee, Chi-Kuang Yao, Seungbok Lee
Summary: Research has shown that the Drosophila homologue of ALS2 plays crucial roles in endosomal trafficking, synaptic development, and neuronal survival. Loss of dALS2 results in age-dependent progressive defects resembling amyotrophic lateral sclerosis, independently of the FNI pathway.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Immunology
Edward L. Y. Chen, Patrick M. Brauer, Elisa C. Martinez, Xiaotian Huang, Ning Yu, Michele K. Anderson, Yang Li, Juan Carlos Zuniga-Pflucker
Summary: Human T cell development requires successful rearrangement of the TCR gene loci, with RAG2 playing a crucial role in this process. While RAG2-KO T lineage progenitors in humans can progress to the DP stage without TCR beta rearrangements, cells expressing rearranged TCR beta-chains exhibit increased survival and proliferation compared to control cells. Transcriptomic analysis revealed differences in gene pathways related to survival and proliferation between TCR beta- and control-transduced RAG2-KO DPs.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zuochen Du, Lu Huang, Xin Dai, Di Yang, Linlin Niu, Heather Miller, Changshun Ruan, Han Li, Leling Hu, Lijia Zhou, Ding Jian, Jian Sun, Xiaoqi Shi, Pei Huang, Yan Chen, Xiaodong Zhao, Chaohong Liu
Summary: The study reveals a new pathway (PGRN-EZH2-PLZF) that regulates the Th2 responses of iNKT cells and provides a potentially new target for asthma treatment.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Genetics & Heredity
Changuk Chung, Xiaoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil H. Mittal, Catharina Donkels, H. Westley Phillips, Zhen Li, Ashley P. L. Marsh, Martin Breuss, Laurel Ball, Camila Araujo Bernardino Garcia, Renee George, Jing Gu, Mingchu Xu, Chelsea Barrows, Kiely James, Valentina Stanley, Anna Nidhiry, Sami Khoury, Gabrielle Howe, Emily Riley, Xin Xu, Brett Copeland, Yifan G. Wang, Se Hoon L. Kim, Hoon-Chul W. Kang, Andreas Schulze-Bonhage, Carola Haas, Horst Urbach, Marco Prinz, David A. Limbrick, Christina Gurnett, Matthew C. Smyth, Shifteh M. Sattar, Mark B. Nespeca, David V. Gonda, Katsumi Y. Imai, Yukitoshi E. Takahashi, Hsin-Hung B. Chen, Jin-Wu Tsai, Valerio Conti, Renzo Guerrini, Orrin Devinsky, Wilson Silva, Helio M. Machado, Gary Mathern, Alexej Abyzov, Sara Baldassari, Stephanie Baulac, Joseph G. Gleeson
Summary: Malformations of cortical development (MCD) are neurological disorders caused by somatic mosaic mutations during embryogenesis, leading to intractable epilepsy. This study identified 69 mutated genes from 283 brain resections and investigated their functional roles using various techniques. Genotype-phenotype correlation analysis revealed specific gene sets associated with different pathophysiological and clinical phenotypes of MCD. The spatiotemporal expression patterns of mutated genes in control and patient brains suggest their critical roles in excitatory neurogenesis and neuronal hyperexcitability.
Article
Endocrinology & Metabolism
Marco Antonio Parra-Montes de Oca, Mariana Gutierrez-Mariscal, Ma Felix Salmeron-Jimenez, Lorraine Jaimes-Hoy, Jean-Louis Charli, Patricia Joseph-Bravo
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Adair Rodriguez-Rodriguez, Ivan Lazcano, Edith Sanchez-Jaramillo, Rosa Maria Uribe, Lorraine Jaimes-Hoy, Patricia Joseph-Bravo, Jean-Louis Charli
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Lorraine Jaimes-Hoy, Fidelia Romero, Jean-Louis Charli, Patricia Joseph-Bravo
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Chemistry, Applied
Yarini Arrebola, Laura Rivera, Alejandro Pedroso, Rory McGuire, Mario E. Valdes Tresanco, Gretchen Bergado, Jean-Louis Charli, Belinda Sanchez, Isel Pascual Alonso
Summary: The study found that bacitracin is a non-competitive inhibitor of porcine kidney APN and APA, with cytotoxic effects on murine melanoma cells and inhibitive effects on APN-like activity. Further experiments are needed to fully understand the mechanisms of action of bacitracin on melanoma cells and its potential therapeutic use.
NATURAL PRODUCT RESEARCH
(2021)
Article
Pediatrics
Roberto C. Licea-Cejudo, Laura K. Arenas-Sandoval, Jonathan Salazar-Leon, Monica Martinez-Martinez, Alfonso Carreon-Rodriguez, Gustavo Pedraza-Alva, Leonor Perez-Martinez
Article
Neurosciences
Carmen Parra-Cid, Eduardo Orozco-Castillo, Julieta Garcia-Lopez, Elena Contreras-Figueroa, Laura E. Ramos-Languren, Clemente Ibarra, Alfonso Carreon-Rodriguez, Michael Aschner, Mina Konigsberg, Abel Santamaria
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2020)
Review
Pharmacology & Pharmacy
Jean-Louis Charli, Adair Rodriguez-Rodriguez, Karina Hernandez-Ortega, Antonieta Cote-Velez, Rosa Maria Uribe, Lorraine Jaimes-Hoy, Patricia Joseph-Bravo
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Isel Pascual Alonso, Laura Rivera Mendez, Mario E. Valdes-Tresanco, Lotfi Bounaadja, Marjorie Schmitt, Yarini Arrebola Sanchez, Luis Alvarez Lajonchere, Jean-Louis Charli, Isabelle Florent
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2020)
Article
Endocrinology & Metabolism
A. Castillo-Campos, A. Gutierrez-Mata, J-L Charli, P. Joseph-Bravo
Summary: Chronic stress was found to blunt the responses of the thyroid axis and brown adipose tissue to cold exposure. The long-term effects of stress on noradrenergic and hormonal signaling may be responsible for thyroid dysfunction.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Endocrinology & Metabolism
Ivan Lazcano, Adair Rodriguez Rodriguez, Rosa Maria Uribe, Aurea Orozco, Patricia Joseph-Bravo, Jean-Louis Charli
Summary: Thyroid hormones are ancient signaling molecules that regulate metabolism and growth in vertebrates through the hypothalamus-pituitary-thyroid axis. The hypothalamic factors that induce TSH secretion vary among vertebrates, but all play a role in activating TH synthesis in the thyroid gland.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Rivera Mendez, Yarini Arrebola, Mario E. Valdes-Tresanco, Lisset Diaz-Guevara, Gretchen Bergado, Belinda Sanchez, Jean-Louis Charli, Isel Pascual Alonso
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Endocrinology & Metabolism
Lorraine Jaimes-Hoy, Adrian Perez-Maldonado, Elian Narvaez Bahena, Natalia de la Cruz Guarneros, Adair Rodriguez-Rodriguez, Jean-Louis Charli, Xavier Soberon, Patricia Joseph-Bravo
Summary: In adult animals, chronic stress can inhibit the basal activity of the HPT axis and its response to cold or voluntary exercise. Maternal separation alters the basal activity of the HPT axis, reducing its response to energy demands and potentially causing epigenetic changes on the Trh promoter.
Article
Plant Sciences
Mario E. Valdes-Tresanco, Yarini Arrebola Sanchez, Laura Rivera Mendez, Fabiola Almeida, Belinda Sanchez, Jean-Louis Charli, Isel Pascual Alonso
Summary: The research findings demonstrate that bestatin is a non-competitive inhibitor of porcine APA, binding to it similarly to porcine aminopeptidase N. Additionally, analogs of bestatin such as probestin and phebestin may interact with the same residues.
INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES
(2021)
Article
Biochemistry & Molecular Biology
Patricia Joseph-Bravo, Ivan Lazcano, Lorraine Jaimes-Hoy, Mariana Gutierrez-Mariscal, Edith Sanchez-Jaramillo, Rosa Maria Uribe, Jean-Louis Charli
FRONTIERS IN BIOSCIENCE-LANDMARK
(2020)
Article
Multidisciplinary Sciences
Erzsebet Farkas, Edina Varga, Balazs Kovacs, Anett Szilvasy-Szabo, Antonieta Cote-Velez, Zoltan Peterfi, Magdalini Matziari, Monika Toth, Dora Zelena, Zsolt Mezriczky, Andrea Kadar, Dora Kovari, Masahiko Watanabe, Masanobu Kano, Ken Mackie, Balazs Rozsa, Yvette Ruska, Blanka Toth, Zoltan Mate, Ferenc Erdelyi, Gabor Szabo, Balazs Gereben, Ronald M. Lechan, Jean-Louis Charli, Patricia Joseph-Bravo, Csaba Fekete
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
