Article
Biology
Wenyu Ding, Changjiang Zhang, Baisong Wang, Xin Zhou, Le Sun, Suijuan Zhong, Jing Liu, Junjing Zhang, Xiaoqun Wang, Qian Wu
Summary: The study reveals the crucial roles of the centrosomal protein Cenpj in neurogenesis, cerebral cortex development, and body weight regulation. Deletion of Cenpj leads to obesity in mice and affects hypothalamic cell proliferation, neuron number, and function, providing insights into the pathological mechanisms of related diseases.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiao-Jing Yu, Yan-Mei Chen, Xiao-Jing Liu, Xiao-Jie Bai, Kai-Li Liu, Li-Yan Fu, Hong-Li Gao, Tian-Ze Sun, Xiao-Lian Shi, Jie Qi, Ying Li, Yu-Ming Kang
Summary: The study found that supplementation of MET can reduce blood glucose, suppress renal sympathetic nerve activity, decrease pro-inflammatory cytokines in the PVN and ARC, attenuate oxidative stress and activation of astrocytes, and restore the balance of neurotransmitter synthetase in T2D diabetic rats.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Pedro Castillo, Mariona Palou, Zhi Xin Yau-Qiu, Ana M. Rodriguez, Andreu Palou, Catalina Pico
Summary: It was found in this study that myo-inositol supplementation during lactation can reverse the effects of fetal malnutrition on hypothalamic structure and metabolic health biomarkers in PBMC in rats, partially due to increased leptin sensitivity.
Article
Biochemistry & Molecular Biology
Yanni Zhang, Qiulei Xi, Ming Zhong, Yi Jiang, Qiulin Zhuang, Zuoyou Ding, Shanjun Tan, Junjie Wang, Hao Liu, Zhige Zhang, Ben Zhou, Guohao Wu
Summary: Cachexia is common in cancer patients and its molecular basis is still unclear. This study investigated the regulatory pathway of tumors on appetite-inhibiting neurons (POMC) in the hypothalamus. Results showed that the tumor-expressed SEMA3D is positively related to POMC expression. Knocking out SEMA3D in mice increased food intake and body weight, and reduced muscle and fat catabolism. SEMA3D enhances POMC neuron activity by activating NRP2 and PlxnD1 expression. This research reveals that SEMA3D may play a vital role in appetite suppression and catabolic metabolism.
Review
Neurosciences
Onur Iyilikci, Marcelo R. Zimmer, Marcelo O. Dietrich
Summary: This review discusses the role of neurons regulating energy metabolism in the relationship between infants and mothers during the perinatal period. Specifically, Agrp neurons in the hypothalamus are highlighted for their significant role in energy regulation. The differences in the function of Agrp neurons between neonates and adults are emphasized, with the former motivating offspring to seek proximity to the caregiver and the latter motivating animals to eat.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Alexa Brown, Franz R. Villaruel, Nadia Chaudhri
Summary: Extinction is a fundamental form of inhibitory learning that is important for adapting to changing environmental contingencies. This study aimed to generate an extensive brain activation map of extinction learning in a rat model of appetitive Pavlovian conditioning. The findings provide novel evidence for the contribution of different brain areas and neural networks in the recall versus extinction of appetitive Pavlovian conditioned responding.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Hitomi Tsuchida, Miku Nonogaki, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
Summary: The study investigated the mechanism of suckling-induced suppression of LH release in rats during late lactation, finding that central KOR signaling plays a role in the suppression, and PVN and SON Dyn neurons may be involved.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Ruksana Yesmin, Miho Watanabe, Adya Saran Sinha, Masaru Ishibashi, Tianying Wang, Atsuo Fukuda
Summary: Activated AgRP neurons in the arcuate nucleus directly project to CRH axon terminals in the median-eminence and modulate the hypothalamic-pituitary-adrenal (HPA) axis via NKCC1-dependent GABAergic excitation. These findings highlight the important role of AgRP neurons in HPA axis regulation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Hossein Khaleghzadeh-Ahangar, Shaghayegh Khandan, Saeideh Khosravi
Summary: Diabetes affects nociception, with insulin in the hypothalamus influencing pain by modulating endorphin release. Insulin in the arcuate nucleus can reduce pain induced by formalin, possibly through the dorsal raphe nucleus.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Nutrition & Dietetics
Fiona Peris-Sampedro, Iris Stoltenborg, Marie Le May, Pol Sole-Navais, Roger A. H. Adan, Suzanne L. Dickson
Summary: Environmental cues from palatable foods can drive rats to overconsume plain chow by impacting meal patterns, stimulating food-seeking and risk-taking behavior, and causing active ghrelin release. These cues recruit cells within the feeding circuitry, including those containing the ghrelin receptor, to powerfully drive food consumption in ways associated with heightened hunger.
Article
Biochemistry & Molecular Biology
Iris Stoltenborg, Fiona Peris-Sampedro, Erik Schele, Marie V. Le May, Roger A. H. Adan, Suzanne L. Dickson
Summary: The availability of Cre-based mouse lines has helped identify the neural circuitry driving hormone effects. As an alternative method, TRAP2 mice provide genetic access to hormone-activated populations. By utilizing TRAP2 mice, researchers visualized and stimulated ghrelin-activated cells, discovering their significant role in inducing an orexigenic response and impacting food choice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Behavioral Sciences
Gilbert J. Kirouac
Summary: This review discusses the anatomical connections of the paraventricular nucleus of the thalamus (PVT) in the brain anxiety network and its role in promoting anxiety-related behaviors. Experimental findings show that the PVT receives signals from the cortex and hypothalamus, and modulates defensive responses by projecting to different brain regions. The PVT also plays a key role in social avoidance in rats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biology
Limei Zhang, Vito S. Hernandez, Charles R. Gerfen, Sunny Z. Jiang, Lilian Zavala, Rafael A. Barrio, Lee E. Eiden
Summary: PACAP, as a co-transmitter, increases neuronal excitability and may enhance anxiety and arousal associated with threat. Through studying the distribution of neurons expressing PACAP and PAC1 in the mouse nervous system, a coherent chemoanatomical picture of PACAP's role in brain motor responses to sensory input is developed.
Article
Neurosciences
Nader Srour, Olivier Lavoie, Axelle Khouma, Moein Minbashi Moeini, Julie Plamondon, Richard Kinkead, Natalie J. Michael, Alexandre Caron
Summary: This study aims to determine the differences in leptin responsiveness of POMC neurons in the arcuate nucleus and the retrochiasmatic area, and provides insights into the electrophysiological properties of a specific subpopulation of POMC neurons. The results indicate that sex is not a major determinant of basal properties and leptin responsiveness of POMC neurons, but females show overall lower responsiveness to leptin.
Article
Neurosciences
Sasuk Kim, Juhee Lim, Yeojin Bang, Jisook Moon, Min-Soo Kwon, Jin Tae Hong, Jeha Jeon, Hyemyung Seo, Hyun Jin Choi
MOLECULAR NEUROBIOLOGY
(2018)
Article
Neurosciences
Juhee Lim, Yeojin Bang, Jong-Hyun Choi, Arum Han, Min-Soo Kwon, Kwang Hyeon Liu, Hyun Jin Choi
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Min-Jung Park, Hyun-Sun Park, Min-Jung You, Jongman Yoo, Seung Hyun Kim, Min-Soo Kwon
MOLECULAR NEUROBIOLOGY
(2019)
Article
Psychiatry
Hoyoung Sohn, Min-Soo Kwon, Sun-Woo Lee, Jongsoo Oh, Min-Kyoung Kim, Sang-Hyuk Lee, Kang Soo Lee, Borah Kim
PSYCHIATRY INVESTIGATION
(2018)
Article
Orthopedics
Dhong Won Lee, In Keun Park, Min Jeong Kim, Woo Jong Kim, Min Soo Kwon, Sung Jin Kang, Jin Goo Kim, Young Yi
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2019)
Article
Chemistry, Medicinal
Joong-Won Ha, Min-Jung You, Hyun-Sun Park, Jong Wan Kim, Min-Soo Kwon
ARCHIVES OF PHARMACAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
JooHyun Jee, Sang Yun Jeong, Han Kyung Kim, Seon Young Choi, Sukin Jeong, Joongwoon Lee, Ji Su Ko, Mi Sun Kim, Min-Soo Kwon, Jongman Yoo
Article
Cell & Tissue Engineering
Joo Hyun Jee, Dong Hyeon Lee, Jisu Ko, Soojung Hahn, Sang Yun Jeong, Han Kyung Kim, Enoch Park, Seon Young Choi, Sukin Jeong, Joong Woon Lee, Han-Jun Cho, Min-Soo Kwon, Jongman Yoo
STEM CELLS INTERNATIONAL
(2019)
Article
Neurosciences
Jaehwa Lim, Hoyoung Sohn, Min-Soo Kwon, Borah Kim
Summary: This study found significantly elevated levels of TNF-alpha and IL-8 in patients with MDD compared to healthy controls, along with lower FA and higher MD and RD values in specific WM regions. Voxel-wise correlation analysis showed a significant relationship between TNF-alpha levels and changes in white matter microstructure in specific brain regions.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Bohyun Yang, Jae-Sang Ryu, Chan Rim, Jung U. Shin, Min-Soo Kwon
Summary: This study aimed to identify the mechanisms underlying anxiety/depressive-like behaviors in atopic dermatitis (AD). The findings suggest that reduced Arg1 positive microglia may contribute to these behaviors through pCREB/BDNF reduction in AD.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Immunology
Min-Jung You, Chan Rim, Youn-Jung Kang, Min-Soo Kwon
Summary: This study developed a new method to obtain mature microglia from mouse NEL at E13.5, which exhibited microglial functions and maintained characteristics in passage culture. Transcriptome analysis showed NEL-MG had better conservation of microglia signature genes compared to neonatal microglia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Kyu-Beom Jang, Min-Jung You, Bohyun Yang, Chan Rim, Hui-Ju Kim, Min-Soo Kwon
Summary: The acidic environment caused by stroke, traumatic brain injury, and Alzheimer's disease can alter the functioning of microglia. However, the mechanisms underlying these functional changes are unclear. This study found that acidic stimuli increased the levels of certain molecules and reduced others in BV2 cells, leading to impaired phagocytic function. Short-term exposure to acidity affected specific signaling pathways, while prolonged exposure normalized some levels and increased others. Inhibiting the ERK pathway restored the functional changes induced by acidic environment in microglia. These findings suggest that targeting the ERK pathway may be a potential strategy for treating microglial dysfunction in neurological disorders.
NEUROCHEMICAL RESEARCH
(2022)
Review
Chemistry, Medicinal
Min-Soo Kwon
Summary: Microglia have long been considered the main culprits in neuroinflammatory responses due to their role as primary phagocytes in the central nervous system (CNS). However, recent research has shown that advanced and precise approaches targeting microglia are more effective in managing neurological disorders. Microglia derived from the yolk sac have a heterogeneous composition and play a crucial role in maintaining CNS homeostasis and phagocytosis. Disruptions in microglia development can lead to neurodevelopmental disorders, and microglia can aggravate or alleviate neuroinflammation depending on the microenvironment.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Psychiatry
Min-Jung You, Chan Rim, Minji Bang, Soyoung Sung, Hui-Ju Kim, Sang-Hyuk Lee, Min-Soo Kwon
Summary: This study found that microglia in patients with panic disorder have unique characteristics, including dysregulation of the cholesterol biosynthesis pathway and impaired phagocytosis, which reflect their clinical phenotype.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Chan Rim, Hyun-Sun Park, Min-Jung You, Bohyun Yang, Hui-Ju Kim, Soyoung Sung, Min-Soo Kwon
Summary: Fetal microglia, being sensitive to changes in the utero environment, may play a role in the sex-biased onset of psychiatric disorders. In this study, prenatal exposure to dexamethasone induced schizophrenia-relevant behaviors in male mice and depressive-like behavior in female mice. The altered microglial function and dopaine system proteins were observed in the affected brain regions. These findings suggest that altered microglial function and increased synaptic pruning may be involved in the occurrence of psychiatric disorders in the prenatal dexamethasone-exposed offspring.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.