Article
Physics, Multidisciplinary
Keisuke Ishihara, Arghyadip Mukherjee, Elena Gromberg, Jan Brugues, Elly M. Tanaka, Frank Juelicher
Summary: Animal organs exhibit complex topologies involving cavities and tubular networks, which are governed by two distinct modes of topological transitions. These transitions can be regulated through a pharmacologically accessible pathway, enabling control over organ shape and topology.
Article
Biology
Min-Jung You, Min-Soo Kwon
Summary: We successfully isolated and cultured mature microglia by studying the developmental process of microglial cells in mouse embryos. This method allows for higher yields of mature microglia compared to previous in vitro models.
Article
Business, Finance
Ahmed Bouteska, Burak Buyukoglu, Ibrahim Halil Eksi
Summary: The study investigates the impact of capital requirements, activity restrictions, and supervisory powers on bank performance and risk. By conducting a GMM system analysis using data from 136 deposit banks operating in 28 European countries between 2011 and 2020, it is found that activity restrictions and capital requirements have a negative effect on performance, while supervisory powers have a positive effect. Furthermore, it is discovered that capital requirements and supervision are inversely related to credit risk.
FINANCE RESEARCH LETTERS
(2023)
Review
Clinical Neurology
Marius Schwabenland, Wolfgang Brueck, Josef Priller, Christine Stadelmann, Hans Lassmann, Marco Prinz
Summary: Microglia, as highly sensitive immune cells in the central nervous system, play crucial roles in various neurological diseases. Recent advances in technology have helped identify new expression profiles and states of microglia, contributing to research on health and diseases.
ACTA NEUROPATHOLOGICA
(2021)
Review
Immunology
Andres Vidal-Itriago, Rowan A. W. Radford, Jason A. A. Aramideh, Cindy Maurel, Natalie M. M. Scherer, Emily K. K. Don, Albert Lee, Roger S. S. Chung, Manuel B. B. Graeber, Marco Morsch
Summary: Microglia, originating from mesoderm, play key roles in the development, homeostasis, and innate immunity of the central nervous system (CNS). Their diverse morphological characteristics are closely related to their wide range of functions. However, our knowledge of the morphophysiological attributes and interactions with neurons of microglia is limited. Exploring the correlation between microglial shape and function is a current challenge and opportunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Hongmei Mou, Ying Yang, Molly A. Riehs, Juliana Barrios, Manjunatha Shivaraju, Adam L. Haber, Daniel T. Montoro, Kimberly Gilmore, Elisabeth A. Haas, Brankica Paunovic, Jayaraj Rajagopal, Sara O. Vargas, Robin L. Haynes, Alan Fine, Wellington Cardoso, Xingbin Ai
Summary: The study identified three distinct types of PNECs in human and mouse airways, showing significant differences in NP expression, homeostatic turnover, and response to injury and disease. These differences likely parallel their distinct cell of origin from basal stem cells or other airway epithelial progenitors.
Article
Chemistry, Multidisciplinary
Chunling Tang, Xinhui Wang, Mirko D'Urso, Cas van der Putten, Nicholas A. Kurniawan
Summary: This study establishes a simple 3D culture system to generate and manipulate NE organoids from hiPSCs, and investigates the roles of actomyosin contractility and YAP signaling in NE development. It also demonstrates the influence of interfacial cues on organoid morphology, floor-plate patterning, and cytoskeletal regulation and YAP activity.
Article
Neurosciences
Arnault Tauziede-Espariat, Guillaume Chotard, Francois le Loarer, Jessica Baud, Rihab Azmani, Volodia Dangouloff-Ros, Nathalie Boddaert, Celine Icher-de-Bouyn, Edouard Gimbert, Lauren Hasty, Alice Metais, Fabrice Chretien, Pascale Varlet
Summary: This article reports a unique case of a central nervous system tumor classified as NET-PATZ1 by DNA methylation analysis, which harbors a novel LARGE1-AFF2 fusion that has not been previously described in soft tissue or the CNS. The case shows similarities in clinical, histopathological, immunophenotypical, genetic, and epigenetic features to previously reported cases of NET-PATZ1. These findings suggest the presence of different histomolecular tumor subtypes within the methylation class NET, PATZ1 fusion-positive, including non PATZ1 fusions, and further cases are needed for better characterization.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Cell Biology
Abdel Rahman Abdel Fattah, Sergei Grebenyuk, Laura P. M. H. de Rooij, Idris Salmon, Adrian Ranga
Summary: During tissue patterning, cells undergo changes in cell fate through the action of morphogens at multiple length scales. However, the coordination of cell fate changes and establishment of spatial organization across these scales is not well understood. In this study, human neural tube organoids were used as models to investigate epithelial patterning. An in silico approach was developed to determine the conditions necessary for patterning. The results showed that cells follow a neighborhood watch mechanism, which is determined by the initial positions of morphogen sources, reflecting scale-invariant phenotypes. The study also identified wingless-related integration site (WNT) and bone morphogenic protein (BMP) as inhibitors of patterning, which was validated in vitro. These findings suggest that developing neuroepithelia employ neighborhood watch-based mechanisms to organize morphogen sources, define cellular identity, and establish patterns.
Article
Green & Sustainable Science & Technology
Wajeeha Aslam, Syed Tehseen Jawaid
Summary: Increased global warming has led to the adoption of ecologically responsible actions in organizations, industries, and nations. This study investigates the determinants of the adoption of green banking practices (GBP) by integrating the diffusion of innovation (DOI) and the Technology-Organizational-Environmental framework (TOE). The findings suggest that GBP is influenced by relative advantage as a technological element, and is positively influenced by organizational factors. Additionally, environmental factors such as regulatory pressure, government support, and environmental uncertainty affect the adoption of GBP. The conclusions of this study have significant implications for banks, lawmakers, and environmentalists, and can aid in achieving sustainable development goals through the implementation of green banking policies.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Multidisciplinary Sciences
Balazs V. Varga, Maryam Faiz, Huijuan Yang, Helena Pivonkova, Shangbang Gao, Gabriel Khelifi, Emma Linderoth, Mei Zhen, Ragnhildur Thora Karadottir, Samer M. Hussein, Andras Nagy
Summary: This study identifies signals that regulate the division of human neural stem cells and their ability to generate cortical neurons and glia. Understanding these mechanisms is vital for the development of regenerative and cell-based therapeutic approaches for neurological conditions.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Seong Min Hong, In Gyoung Ju, Jin Hee Kim, Sang Cheol Park, Jin Gyu Choi, Mi Won Sohn, Myung Sook Oh, Sun Yeou Kim
Summary: Neuroinflammation is associated with the pathogenesis of neurodegenerative disorders. The study found that a functional food mixture, CCL01, can inhibit over-activated microglial cells and reduce the expression levels of inflammatory mediators and pro-inflammatory cytokines. The results showed that CCL01 exerts its anti-neuroinflammatory effects by regulating the MAPK/NF-κB pathway and the Nrf2/HO-1 pathway.
Article
Business, Finance
Eunsuh Lee, Chaehyun Kim, Maria A. Leach-Lopez
Summary: Banking competition increases cost stickiness of non-financial firms by intensifying competitive pressure and improving the availability of credit. This study contributes to existing literature by documenting the effect of banking competition on cost behavior and the determinants of cost stickiness.
FINANCE RESEARCH LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Bijay Parajuli, Schuichi Koizumi
Summary: Microglia are specialized macrophages in the central nervous system that play a crucial role in neural circuit development, neurotransmission regulation, and brain homeostasis. However, chronic inflammation can lead to neural dysfunction and neurodegeneration caused by abnormal functions of microglia.
NEUROCHEMICAL RESEARCH
(2023)
Article
Social Sciences, Interdisciplinary
Bjorn Schiermer
Summary: This paper examines why conventional subcultural and post-subcultural research have overlooked the collective and material aspects of subcultural practice. It also explores recent efforts to include these dimensions and aims to develop such perspectives further. The paper argues for a new embedded perspective on the material and collective dimensions of subcultural practice.
JOURNAL OF YOUTH STUDIES
(2023)
Article
Neurosciences
Jaehwa Lim, Hoyoung Sohn, Min-Soo Kwon, Borah Kim
Summary: This study found significantly elevated levels of TNF-alpha and IL-8 in patients with MDD compared to healthy controls, along with lower FA and higher MD and RD values in specific WM regions. Voxel-wise correlation analysis showed a significant relationship between TNF-alpha levels and changes in white matter microstructure in specific brain regions.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Bohyun Yang, Jae-Sang Ryu, Chan Rim, Jung U. Shin, Min-Soo Kwon
Summary: This study aimed to identify the mechanisms underlying anxiety/depressive-like behaviors in atopic dermatitis (AD). The findings suggest that reduced Arg1 positive microglia may contribute to these behaviors through pCREB/BDNF reduction in AD.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kyu-Beom Jang, Min-Jung You, Bohyun Yang, Chan Rim, Hui-Ju Kim, Min-Soo Kwon
Summary: The acidic environment caused by stroke, traumatic brain injury, and Alzheimer's disease can alter the functioning of microglia. However, the mechanisms underlying these functional changes are unclear. This study found that acidic stimuli increased the levels of certain molecules and reduced others in BV2 cells, leading to impaired phagocytic function. Short-term exposure to acidity affected specific signaling pathways, while prolonged exposure normalized some levels and increased others. Inhibiting the ERK pathway restored the functional changes induced by acidic environment in microglia. These findings suggest that targeting the ERK pathway may be a potential strategy for treating microglial dysfunction in neurological disorders.
NEUROCHEMICAL RESEARCH
(2022)
Review
Chemistry, Medicinal
Min-Soo Kwon
Summary: Microglia have long been considered the main culprits in neuroinflammatory responses due to their role as primary phagocytes in the central nervous system (CNS). However, recent research has shown that advanced and precise approaches targeting microglia are more effective in managing neurological disorders. Microglia derived from the yolk sac have a heterogeneous composition and play a crucial role in maintaining CNS homeostasis and phagocytosis. Disruptions in microglia development can lead to neurodevelopmental disorders, and microglia can aggravate or alleviate neuroinflammation depending on the microenvironment.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Da-Yoon Jang, Bohyun Yang, Min-Jung You, Chan Rim, Hui-Ju Kim, Soyoung Sung, Min-Soo Kwon
Summary: This study investigates the mechanism by which fluoxetine affects microglial phagocytosis and finds that it reduces phagocytic function by impacting REV-ERB alpha and BMAL1 nucleocytoplasmic transport. The study also reveals that the inhibition of ERK mimics the effects of fluoxetine on microglia.
NEUROCHEMICAL RESEARCH
(2023)
Article
Psychiatry
Min-Jung You, Chan Rim, Minji Bang, Soyoung Sung, Hui-Ju Kim, Sang-Hyuk Lee, Min-Soo Kwon
Summary: This study found that microglia in patients with panic disorder have unique characteristics, including dysregulation of the cholesterol biosynthesis pathway and impaired phagocytosis, which reflect their clinical phenotype.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Chan Rim, Hyun-Sun Park, Min-Jung You, Bohyun Yang, Hui-Ju Kim, Soyoung Sung, Min-Soo Kwon
Summary: Fetal microglia, being sensitive to changes in the utero environment, may play a role in the sex-biased onset of psychiatric disorders. In this study, prenatal exposure to dexamethasone induced schizophrenia-relevant behaviors in male mice and depressive-like behavior in female mice. The altered microglial function and dopaine system proteins were observed in the affected brain regions. These findings suggest that altered microglial function and increased synaptic pruning may be involved in the occurrence of psychiatric disorders in the prenatal dexamethasone-exposed offspring.
