The Paraventricular Nucleus of the Thalamus as an Integrating and Relay Node in the Brain Anxiety Network

The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues

(2020) Joshua L. Haight et al.   PSYCHOPHARMACOLOGY

Heterogeneity in the Paraventricular Thalamus: The Traffic Light of Motivated Behaviors

(2020) Jacqueline F. McGinty et al.   Frontiers in Behavioral Neuroscience

The Neurobiology of Fear Generalization

(2019) Arun Asok et al.   Frontiers in Behavioral Neuroscience

Are periaqueductal grey and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review

(2019) Carlos Silva et al.   PROGRESS IN NEUROBIOLOGY

Enhanced activity of pyramidal neurons in the infralimbic cortex drives anxiety behavior

(2019) Laura Berg et al.   PLoS One

Paraventricular thalamus controls behavior during motivational conflict

(2019) Eun A Choi et al.   JOURNAL OF NEUROSCIENCE

Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing

(2019) James M. Otis et al.   NEURON

The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats

(2019) Paolo Campus et al.   eLife

Orexin in the Posterior Paraventricular Thalamus Mediates Hunger-Related Signals in the Nucleus Accumbens Core

(2019) Julie Meffre et al.   CURRENT BIOLOGY

Role of the anterior agranular insular cortex in the modulation of fear and anxiety

(2019) Tianyao Shi et al.   BRAIN RESEARCH BULLETIN

An endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability

(2019) Oakleigh M. Folkes et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of electrical stimulation of the infralimbic and prelimbic cortices on anxiolytic-like behavior of rats during the elevated plus-maze test, with particular reference to multiunit recording of the behavior-associated neural activity

(2018) Tomoko Shimizu et al.   BEHAVIOURAL BRAIN RESEARCH

Orexins and stress

(2018) Laura A. Grafe et al.   FRONTIERS IN NEUROENDOCRINOLOGY

A central extended amygdala circuit that modulates anxiety

(2018) Sandra Ahrens et al.   JOURNAL OF NEUROSCIENCE

Stress peptides sensitize fear circuitry to promote passive coping

(2018) Pinelopi Pliota et al.   MOLECULAR PSYCHIATRY

Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour

(2018) Joseph LeDoux et al.   NATURE REVIEWS NEUROSCIENCE

Cooperative and dissociable involvement of the nucleus accumbens core and shell in the promotion and inhibition of actions during active and inhibitory avoidance

(2018) Patrick T. Piantadosi et al.   NEUROPHARMACOLOGY

Anterior Paraventricular Thalamus to Nucleus Accumbens Projection Is Involved in Feeding Behavior in a Novel Environment

(2018) Jingjing Cheng et al.   Frontiers in Molecular Neuroscience

The contribution of orexins to sex differences in the stress response

(2018) Laura A. Grafe et al.   BRAIN RESEARCH

Complementary Neural Circuits for Divergent Effects of Oxytocin: Social Approach Versus Social Anxiety

(2018) Michael Q. Steinman et al.   BIOLOGICAL PSYCHIATRY

Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety

(2018) Ethan M. Anderson et al.   NEUROPSYCHOPHARMACOLOGY

The paraventricular thalamus is a critical thalamic area for wakefulness

(2018) Shuancheng Ren et al.   SCIENCE

Dynamic salience processing in paraventricular thalamus gates associative learning

(2018) Yingjie Zhu et al.   SCIENCE

mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice

(2018) Kaziya M. Lee et al.   Frontiers in Pharmacology

Paraventricular Thalamus Balances Danger and Reward

(2017) Eun A. Choi et al.   JOURNAL OF NEUROSCIENCE

Optogenetic silencing of a corticotropin-releasing factor pathway from the central amygdala to the bed nucleus of the stria terminalis disrupts sustained fear

(2017) A Asok et al.   MOLECULAR PSYCHIATRY

Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

(2017) James M. Otis et al.   NATURE

Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission

(2017) Fabricio H. Do-Monte et al.   NEURON

A Key Role for Neurotensin in Chronic-Stress-Induced Anxiety-Like Behavior in Rats

(2017) Catherine P Normandeau et al.   NEUROPSYCHOPHARMACOLOGY

The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research

(2017) Andrew S. Fox et al.   NEUROSCIENCE LETTERS

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

(2017) Pascal Bonaventure et al.   Frontiers in Pharmacology

Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework

(2016) Joseph E. LeDoux et al.   AMERICAN JOURNAL OF PSYCHIATRY

The infralimbic and prelimbic medial prefrontal cortices have differential functions in the expression of anxiety-like behaviors in mice

(2016) Satoshi Suzuki et al.   BEHAVIOURAL BRAIN RESEARCH

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors

(2016) Ja Wook Koo et al.   BIOLOGICAL PSYCHIATRY

Anxiety

(2016) Michelle G Craske et al.   LANCET

Retrieving fear memories, as time goes by…

(2016) F H Do Monte et al.   MOLECULAR PSYCHIATRY

A thalamic input to the nucleus accumbens mediates opiate dependence

(2016) Yingjie Zhu et al.   NATURE

Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior

(2016) Gwenaël Labouèbe et al.   NATURE NEUROSCIENCE

Context Processing and the Neurobiology of Post-Traumatic Stress Disorder

(2016) Israel Liberzon et al.   NEURON

Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

(2016) Shanna L Resendez et al.   eLife

The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action

(2015) Stan B. Floresco   Annual Review of Psychology

Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress

(2015) T. Chase Francis et al.   BIOLOGICAL PSYCHIATRY

Hypothalamic, feeding/arousal-related peptidergic projections to the paraventricular thalamic nucleus in the rat

(2015) Ji S. Lee et al.   BRAIN RESEARCH

Hippocampus and two-way active avoidance conditioning: Contrasting effects of cytotoxic lesion and temporary inactivation

(2015) Jia Wang et al.   HIPPOCAMPUS

Induction of c-Fos immunoreactivity in the amygdala of mice expressing anxiety-like behavior after local perfusion of veratrine in the prelimbic medial prefrontal cortex

(2015) Misa Yamada et al.   JOURNAL OF NEURAL TRANSMISSION

Active Avoidance Requires a Serial Basal Amygdala to Nucleus Accumbens Shell Circuit

(2015) F. Ramirez et al.   JOURNAL OF NEUROSCIENCE

The paraventricular thalamus controls a central amygdala fear circuit

(2015) Mario A. Penzo et al.   NATURE

A temporal shift in the circuits mediating retrieval of fear memory

(2015) Fabricio H. Do-Monte et al.   NATURE

Resolving the neural circuits of anxiety

(2015) Gwendolyn G Calhoon et al.   NATURE NEUROSCIENCE

NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

(2015) Kristen E Pleil et al.   NATURE NEUROSCIENCE

Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward

(2015) Ream Al-Hasani et al.   NEURON

Architectural Representation of Valence in the Limbic System

(2015) Praneeth Namburi et al.   NEUROPSYCHOPHARMACOLOGY

Limbic thalamus and state-dependent behavior: The paraventricular nucleus of the thalamic midline as a node in circadian timing and sleep/wake-regulatory networks

(2015) Valeria Colavito et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Placing the paraventricular nucleus of the thalamus within the brain circuits that control behavior

(2015) Gilbert J. Kirouac   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

GABA-induced inactivation of dorsal midline thalamic subregions has distinct effects on emotional behaviors

(2015) Jessica R. Barson et al.   NEUROSCIENCE LETTERS

Extending the amygdala in theories of threat processing

(2015) Andrew S. Fox et al.   TRENDS IN NEUROSCIENCES

Role of Prelimbic GABAergic Circuits in Sensory and Emotional Aspects of Neuropathic Pain

(2015) Zizhen Zhang et al.   Cell Reports

Blocking of orexin receptors in the paraventricular nucleus of the thalamus has no effect on the expression of conditioned fear in rats

(2015) Xinwen Dong et al.   Frontiers in Behavioral Neuroscience

Natural Neural Projection Dynamics Underlying Social Behavior

(2014) Lisa A. Gunaydin et al.   CELL

Prefrontal neuronal circuits of contextual fear conditioning

(2014) R. R. Rozeske et al.   GENES BRAIN AND BEHAVIOR

Motivational activation: a unifying hypothesis of orexin/hypocretin function

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

Amygdala Microcircuits Controlling Learned Fear

(2014) Sevil Duvarci et al.   NEURON

Distinct anxiogenic/anxiolytic effects exerted by the hamster lateral amygdalar nucleus injected with ORX-A or ORX-B in the presence of a GABAergic agonist

(2014) Ennio Avolio et al.   NEUROREPORT

Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance

(2014) Zhao-Cai Jiang et al.   NEUROSCIENCE LETTERS

The hypothalamus and periaqueductal gray are the sources of dopamine fibers in the paraventricular nucleus of the thalamus in the rat

(2014) Sa Li et al.   Frontiers in Neuroanatomy

Distributed circuits underlying anxiety

(2014) Avishek Adhikari   Frontiers in Behavioral Neuroscience

Lesions of the posterior paraventricular nucleus of the thalamus attenuate fear expression

(2014) Yonghui Li et al.   Frontiers in Behavioral Neuroscience

The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior

(2014) Alessandra Matzeu et al.   Frontiers in Behavioral Neuroscience

Orexins (hypocretins) contribute to fear and avoidance in rats exposed to a single episode of footshocks

(2013) Xiaoyu Chen et al.   Brain Structure & Function

Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning

(2013) Fernando H. F. Alves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gastrin-releasing peptide acts via postsynaptic BB2receptors to modulate inward rectifier K+and TRPV1-like conductances in rat paraventricular thalamic neurons

(2013) M. L. H. J. Hermes et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diverging neural pathways assemble a behavioural state from separable features in anxiety

(2013) Sung-Yon Kim et al.   NATURE

Distinct extended amygdala circuits for divergent motivational states

(2013) Joshua H. Jennings et al.   NATURE

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

(2013) Gül Dölen et al.   NATURE

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

(2013) Mazen A. Kheirbek et al.   NEURON

Enhanced excitability in the infralimbic cortex produces anxiety-like behaviors

(2013) Lin-Lin Bi et al.   NEUROPHARMACOLOGY

A Neural Circuit for Memory Specificity and Generalization

(2013) W. Xu et al.   SCIENCE

Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-induced anxiety behavior

(2013) Ana P. Ventura-Silva et al.   Frontiers in Behavioral Neuroscience

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

(2012) Dipesh Chaudhury et al.   NATURE

Yohimbine anxiogenesis in the elevated plus maze is disrupted by bilaterally disconnecting the bed nucleus of the stria terminalis from the central nucleus of the amygdala

(2012) L. Cai et al.   NEUROSCIENCE

Isolation rearing attenuates social interaction-induced expression of immediate early gene protein products in the medial prefrontal cortex of male and female rats

(2012) Vanessa L. Wall et al.   PHYSIOLOGY & BEHAVIOR

An animal model of panic vulnerability with chronic disinhibition of the dorsomedial/perifornical hypothalamus

(2012) Philip L. Johnson et al.   PHYSIOLOGY & BEHAVIOR

Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats

(2012) Elizabeth A. Lungwitz et al.   PHYSIOLOGY & BEHAVIOR

The brain orexin system and almorexant in fear-conditioned startle reactions in the rat

(2012) Michel A. Steiner et al.   PSYCHOPHARMACOLOGY

Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder

(2011) Xiaoyu Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Sources of inputs to the anterior and posterior aspects of the paraventricular nucleus of the thalamus

(2011) Sa Li et al.   Brain Structure & Function

Orexins/Hypocretins Act in the Posterior Paraventricular Thalamic Nucleus During Repeated Stress to Regulate Facilitation to Novel Stress

(2011) Willem Heydendael et al.   ENDOCRINOLOGY

Anatomical characterization of the neuropeptide S system in the mouse brain by in situ hybridization and immunohistochemistry

(2011) Stewart D. Clark et al.   JOURNAL OF COMPARATIVE NEUROLOGY

I B Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity

(2011) D. J. Christoffel et al.   JOURNAL OF NEUROSCIENCE

Role of amygdala–prefrontal cortex circuitry in regulating the expression of contextual fear memory

(2011) Carl W. Stevenson   NEUROBIOLOGY OF LEARNING AND MEMORY

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity

(2011) Avishek Adhikari et al.   NEURON

A time-dependent role of midline thalamic nuclei in the retrieval of fear memory

(2011) Nancy Padilla-Coreano et al.   NEUROPHARMACOLOGY

The dorsomedial hypothalamus and the central pathways involved in the cardiovascular response to emotional stress

(2011) M.A.P. Fontes et al.   NEUROSCIENCE

Effects of GABA ligands injected into the nucleus accumbens shell on fear/anxiety-like and feeding behaviours in food-deprived rats

(2011) Ana Paula Fraga Lopes et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fos expression following regimens of predator stress versus footshock that differentially affect prepulse inhibition in rats

(2011) Sarah K. Baisley et al.   PHYSIOLOGY & BEHAVIOR

A combined study of behavior and Fos expression in limbic structures after re-testing Wistar rats in the elevated plus-maze

(2010) O.Y. Galvis-Alonso et al.   BRAIN RESEARCH BULLETIN

Prefrontal control of fear: more than just extinction

(2010) Francisco Sotres-Bayon et al.   CURRENT OPINION IN NEUROBIOLOGY

Orexin neurons are indispensable for stress-induced thermogenesis in mice

(2010) Wei Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Synchronized Activity between the Ventral Hippocampus and the Medial Prefrontal Cortex during Anxiety

(2010) Avishek Adhikari et al.   NEURON

Different role of the ventral medial prefrontal cortex on modulation of innate and associative learned fear

(2010) S.F. Lisboa et al.   NEUROSCIENCE

The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats

(2010) D.L. Choi et al.   NEUROSCIENCE

The participation of a neurocircuit from the paraventricular thalamus to amygdala in the depressive like behavior

(2010) Lei Zhu et al.   NEUROSCIENCE LETTERS

Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus

(2010) Yonghui Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal

(2010) Yonghui Li et al.   PHYSIOLOGY & BEHAVIOR

Orexins in the paraventricular nucleus of the thalamus mediate anxiety-like responses in rats

(2010) Yonghui Li et al.   PSYCHOPHARMACOLOGY

Hypocretin/orexin in arousal and stress

(2009) Craig W. Berridge et al.   BRAIN RESEARCH

The role of hypocretin in driving arousal and goal-oriented behaviors

(2009) Benjamin Boutrel et al.   BRAIN RESEARCH

Hypocretin /orexin contributes to the expression of some but not all forms of stress and arousal

(2009) Teri M. Furlong et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Hippocampal and extrahippocampal systems compete for control of contextual fear: Role of ventral subiculum and amygdala

(2009) J. C. Biedenkapp et al.   LEARNING & MEMORY

The Neurocircuitry of Fear, Stress and Anxiety Disorders

(2009) Lisa M Shin et al.   NEUROPSYCHOPHARMACOLOGY

Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats

(2009) Yonghui Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Roles for the subiculum in spatial information processing, memory, motivation and the temporal control of behaviour

(2009) Shane M. O'Mara et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses

(2009) D.L. Walker et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The ventral basal ganglia, a selection mechanism at the crossroads of space, strategy, and reward.

(2009) Mark D. Humphries et al.   PROGRESS IN NEUROBIOLOGY

Projections of the paraventricular and paratenial nuclei of the dorsal midline thalamus in the rat

(2008) Robert P. Vertes et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin  -Opioid System

(2008) B. B. Land et al.   JOURNAL OF NEUROSCIENCE

Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear

(2008) V. Laurent et al.   LEARNING & MEMORY

Emotional environments retune the valence of appetitive versus fearful functions in nucleus accumbens

(2008) Sheila M Reynolds et al.   NATURE NEUROSCIENCE

Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2

(2008) Michael R. Bruchas et al.   NEUROREPORT

Exposure to an open-field arena increases c-Fos expression in a subpopulation of neurons in the dorsal raphe nucleus, including neurons projecting to the basolateral amygdaloid complex

(2008) M.W. Hale et al.   NEUROSCIENCE

Rats exposed to traumatic stress bury unfamiliar objects — A novel measure of hyper-vigilance in PTSD models?

(2008) Eva Mikics et al.   PHYSIOLOGY & BEHAVIOR

The microinjection of AMPA receptor antagonist into the accumbens shell, but not into the accumbens core, induces anxiolysis in an animal model of anxiety

(2007) Isabel Cristina da Cunha et al.   BEHAVIOURAL BRAIN RESEARCH