Insights from systems pharmacology into cardiovascular drug discovery and therapy

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

(2013) Peter Csermely et al.   PHARMACOLOGY & THERAPEUTICS

A systematic identification of multiple toxin–target interactions based on chemical, genomic and toxicological data

(2013) Wei Zhou et al.   TOXICOLOGY

HINT: High-quality protein interactomes and their applications in understanding human disease

(2012) Jishnu Das et al.   BMC Systems Biology

The Emerging Paradigm of Network Medicine in the Study of Human Disease

(2012) Stephen Y. Chan et al.   CIRCULATION RESEARCH

Deciphering the molecular basis of human cardiovascular disease through network biology

(2012) Stephen Y. Chan et al.   CURRENT OPINION IN CARDIOLOGY

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Systems-based approaches to cardiovascular disease

(2012) W. Robb MacLellan et al.   Nature Reviews Cardiology

Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development

(2012) K. Lage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Challenges and Opportunities for Cardiovascular Disease Prevention

(2011) Manuel Franco et al.   AMERICAN JOURNAL OF MEDICINE

Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs

(2011) Lei Xie et al.   Annual Review of Pharmacology and Toxicology

Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action

(2011) Shan Zhao et al.   Annual Review of Pharmacology and Toxicology

Strategic Approaches to Unraveling Genetic Causes of Cardiovascular Diseases

(2011) A.J. Marian et al.   CIRCULATION RESEARCH

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

(2011) F. Zhu et al.   NUCLEIC ACIDS RESEARCH

Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases

(2011) Anna Bauer-Mehren et al.   PLoS One

Cardiovascular Networks

(2010) Aldons J. Lusis et al.   CIRCULATION

Rational approaches to targeted polypharmacology: creating and navigating protein–ligand interaction networks

(2010) James T Metz et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

(2010) Guillaume Pidoux et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Dissecting spatio-temporal protein networks driving human heart development and related disorders

(2010) Kasper Lage et al.   Molecular Systems Biology

Accelerating the pulse of cardiovascular R&D

(2010) Andrew Plump   NATURE REVIEWS DRUG DISCOVERY

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Unveiling the role of network and systems biology in drug discovery

(2010) Albert Pujol et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The analysis of the drug–targets based on the topological properties in the human protein–protein interaction network

(2009) Mingzhu Zhu et al.   JOURNAL OF DRUG TARGETING

The impact of cellular networks on disease comorbidity

(2009) Juyong Park et al.   Molecular Systems Biology

An Uncertain Future for Cardiovascular Drug Development?

(2009) Alan M. Garber   NEW ENGLAND JOURNAL OF MEDICINE

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

A Dynamic Network Approach for the Study of Human Phenotypes

(2009) César A. Hidalgo et al.   PLoS Computational Biology

Fast Gene Ontology based clustering for microarray experiments

(2009) Kristian Ovaska et al.   BioData Mining

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

(2008) M J Forrest et al.   BRITISH JOURNAL OF PHARMACOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

The implications of human metabolic network topology for disease comorbidity

(2008) D.- S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA