The Emerging Paradigm of Network Medicine in the Study of Human Disease

Systems pharmacology of complex diseases

(2012) Jens Hansen et al.   Annals of the New York Academy of Sciences

Crosstalk between transcription factors and microRNAs in human protein interaction network

(2012) Chen-Ching Lin et al.   BMC Systems Biology

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Personalized Cardiovascular Medicine and Drug Development

(2012) Joseph Loscalzo   CIRCULATION

MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension

(2012) Victoria N. Parikh et al.   CIRCULATION

Deciphering the molecular basis of human cardiovascular disease through network biology

(2012) Stephen Y. Chan et al.   CURRENT OPINION IN CARDIOLOGY

Identification of microRNA-regulated gene networks by expression analysis of target genes

(2012) Vincenzo Alessandro Gennarino et al.   GENOME RESEARCH

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Data-Driven Prediction of Drug Effects and Interactions

(2012) N. P. Tatonetti et al.   Science Translational Medicine

Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine

(2012) Elliott Antman et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Understanding dynamics using sensitivity analysis: caveat and solution

(2011) Thanneer M Perumal et al.   BMC Systems Biology

Network for Activation of Human Endothelial Cells by Oxidized Phospholipids

(2011) Casey E. Romanoski et al.   CIRCULATION RESEARCH

Protein Interaction-Based Genome-Wide Analysis of Incident Coronary Heart Disease

(2011) Majken K. Jensen et al.   Circulation-Cardiovascular Genetics

Coronary Artery Endothelial Transcriptome In Vivo

(2011) Mete Civelek et al.   Circulation-Cardiovascular Genetics

Systems biology of heart failure, challenges and hopes

(2011) Frederick E Dewey et al.   CURRENT OPINION IN CARDIOLOGY

Computational tools for polypharmacology and repurposing

(2011) Janosch Achenbach et al.   Future Medicinal Chemistry

Systems medicine and metabolic modelling

(2011) A. Mardinoglu et al.   JOURNAL OF INTERNAL MEDICINE

A novel integrative network approach to understand the interplay between cardiovascular disease and other complex disorders

(2011) Deniz Rende et al.   Molecular BioSystems

PREDICT: a method for inferring novel drug indications with application to personalized medicine

(2011) A. Gottlieb et al.   Molecular Systems Biology

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

TarBase 6.0: capturing the exponential growth of miRNA targets with experimental support

(2011) T. Vergoulis et al.   NUCLEIC ACIDS RESEARCH

NAViGaTing the Micronome – Using Multiple MicroRNA Prediction Databases to Identify Signalling Pathway-Associated MicroRNAs

(2011) Elize A. Shirdel et al.   PLoS One

Functional characterization of bacterial sRNAs using a network biology approach

(2011) S. R. Modi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems Biology--Biomedical Modeling

(2011) E. A. Sobie et al.   Science Signaling

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

Systems biology and the future of medicine

(2011) Joseph Loscalzo et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Drug repurposing and adverse event prediction using high-throughput literature analysis

(2011) Spyros N. Deftereos et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The power of protein interaction networks for associating genes with diseases

(2010) Saket Navlakha et al.   BIOINFORMATICS

Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure

(2010) Frederick E. Dewey et al.   Circulation-Cardiovascular Genetics

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

Classic and contemporary approaches to modeling biochemical reactions

(2010) W. W. Chen et al.   GENES & DEVELOPMENT

Clinical assessment incorporating a personal genome

(2010) Euan A Ashley et al.   LANCET

Dissecting spatio-temporal protein networks driving human heart development and related disorders

(2010) Kasper Lage et al.   Molecular Systems Biology

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Blueprint for antimicrobial hit discovery targeting metabolic networks

(2010) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems Pharmacology of Arrhythmias

(2010) S. I. Berger et al.   Science Signaling

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets

(2010) Silpa Suthram et al.   PLoS Computational Biology

Associating Genes and Protein Complexes with Disease via Network Propagation

(2010) Oron Vanunu et al.   PLoS Computational Biology

Ranking Genes by Their Co-expression to Subsets of Pathway Members

(2009) Priit Adler et al.   Annals of the New York Academy of Sciences

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Cancer systems biology: a network modeling perspective

(2009) P. K. Kreeger et al.   CARCINOGENESIS

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses

(2009) A P Chiang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The use of network analyses for elucidating mechanisms in cardiovascular disease

(2009) Diego Diez et al.   Molecular BioSystems

Disease signatures are robust across tissues and experiments

(2009) Joel T Dudley et al.   Molecular Systems Biology

A network view of disease and compound screening

(2009) Eric E. Schadt et al.   NATURE REVIEWS DRUG DISCOVERY

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Expression-Based Network Biology Identifies Alteration in Key Regulatory Pathways of Type 2 Diabetes and Associated Risk/Complications

(2009) Urmi Sengupta et al.   PLoS One

A network biology approach to aging in yeast

(2009) D. R. Lorenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Gene Networks That Count

(2009) A. E. Friedland et al.   SCIENCE

Drug Discovery Using Chemical Systems Biology: Identification of the Protein-Ligand Binding Network To Explain the Side Effects of CETP Inhibitors

(2009) Li Xie et al.   PLoS Computational Biology

Building Disease-Specific Drug-Protein Connectivity Maps from Molecular Interaction Networks and PubMed Abstracts

(2009) Jiao Li et al.   PLoS Computational Biology

A Computational Screen for Regulators of Oxidative Phosphorylation Implicates SLIRP in Mitochondrial RNA Homeostasis

(2009) Joshua M. Baughman et al.   PLoS Genetics

Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA-damage signal transduction pathway

(2008) Kazunari Iwamoto et al.   BIOSYSTEMS

Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death

(2008) Michael A. Kohanski et al.   CELL

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY

An empirical framework for binary interactome mapping

(2008) Kavitha Venkatesan et al.   NATURE METHODS

Literature-curated protein interaction datasets

(2008) Michael E Cusick et al.   NATURE METHODS

GraphWeb: mining heterogeneous biological networks for gene modules with functional significance

(2008) J. Reimand et al.   NUCLEIC ACIDS RESEARCH

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE

Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases

(2008) Monika Ray et al.   GENOME BIOLOGY

Inferring regulatory networks

(2007) Huai Li   Frontiers in Bioscience-Landmark