Systems-based approaches to cardiovascular disease

CHAC1/MGC4504 Is a Novel Proapoptotic Component of the Unfolded Protein Response, Downstream of the ATF4-ATF3-CHOP Cascade

(2014) I. N. Mungrue et al.   JOURNAL OF IMMUNOLOGY

Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power

(2011) Trey Ideker et al.   CELL

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Modeling the Cell Cycle: Why Do Certain Circuits Oscillate?

(2011) James E. Ferrell et al.   CELL

Impulse Control: Temporal Dynamics in Gene Transcription

(2011) Nir Yosef et al.   CELL

Pattern, Growth, and Control

(2011) Arthur D. Lander   CELL

Status and Prospects for Discovery and Verification of New Biomarkers of Cardiovascular Disease by Proteomics

(2011) Robert E. Gerszten et al.   CIRCULATION RESEARCH

Network for Activation of Human Endothelial Cells by Oxidized Phospholipids

(2011) Casey E. Romanoski et al.   CIRCULATION RESEARCH

Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques

(2011) W.-L. Su et al.   Molecular Systems Biology

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

(2011) Kerrin S Small et al.   NATURE GENETICS

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

(2011) John F Peden et al.   NATURE GENETICS

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Heart failure: advances through genomics

(2011) Esther E. Creemers et al.   NATURE REVIEWS GENETICS

Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk

(2011) Cinnamon S. Bloss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Carvedilol pharmacokinetics and pharmacodynamics in relation toCYP2D6andADRBpharmacogenetics

(2011) Daniel Sehrt et al.   PHARMACOGENOMICS

The Accelerator

(2011) E. S. Lander   SCIENCE

Systems Genetics

(2011) J. H. Nadeau et al.   SCIENCE

Systems medicine and integrated care to combat chronic noncommunicable diseases

(2011) Jean Bousquet et al.   Genome Medicine

Is My Network Module Preserved and Reproducible?

(2011) Peter Langfelder et al.   PLoS Computational Biology

Relation of ADRB1, CYP2D6, and UGT1A1 Polymorphisms With Dose of, and Response to, Carvedilol or Metoprolol Therapy in Patients With Chronic Heart Failure

(2010) Linnea M. Baudhuin et al.   AMERICAN JOURNAL OF CARDIOLOGY

Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells

(2010) Casey E. Romanoski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies

(2010) Hua Zhong et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes

(2010) Elias Chaibub Neto et al.   Annals of Applied Statistics

Physiological Insights Gained from Gene Expression Analysis in Obesity and Diabetes

(2010) Mark P. Keller et al.   Annual Review of Nutrition

Is human blood a good surrogate for brain tissue in transcriptional studies?

(2010) Chaochao Cai et al.   BMC GENOMICS

A Macrophage Sterol-Responsive Network Linked to Atherogenesis

(2010) Lev Becker et al.   Cell Metabolism

Cardiovascular Networks

(2010) Aldons J. Lusis et al.   CIRCULATION

Identifying Patients at High Risk of a Cardiovascular Event in the Near Future

(2010) Kim A. Eagle et al.   CIRCULATION

Toward Metabolomic Signatures of Cardiovascular Disease

(2010) Gregory D. Lewis et al.   Circulation-Cardiovascular Genetics

Autophagy in Hypertensive Heart Disease

(2010) Zhao V. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A global protein–lipid interactome map

(2010) Marc Brehme et al.   Molecular Systems Biology

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

2009 FDA drug approvals

(2010) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Gene-Expression Profiling for Rejection Surveillance after Cardiac Transplantation

(2010) Michael X. Pham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

(2010) Jeremy A. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biology-old wine in a new bottle or is the bottle changing the wine?

(2010) Joseph H. Nadeau et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Systems medicine-viewed through the real and computing lenses

(2010) Shankar Subramaniam et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Genomic Analysis of Left Ventricular Remodeling

(2009) Rizwan Sarwar et al.   CIRCULATION

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

(2009) Xia Yang et al.   NATURE GENETICS

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

(2009) Stuart J. Connolly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Scale-Free Networks: A Decade and Beyond

(2009) Albert-László Barabási   SCIENCE

The network as the target

(2009) Julie E. Baggs et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Systems Biology and Medicine: A New Take on an Old Paradigm

(2009) Joseph H. Nadeau et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) Study

(2009) Sara Hägg et al.   PLoS Genetics

Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease

(2009) Radu Dobrin et al.   GENOME BIOLOGY

Elucidating the Role of Gonadal Hormones in Sexually Dimorphic Gene Coexpression Networks

(2008) Atila van Nas et al.   ENDOCRINOLOGY

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

(2008) M. P. Keller et al.   GENOME RESEARCH

Lack of Association Between Adrenergic Receptor Genotypes and Survival in Heart Failure Patients Treated With Carvedilol or Metoprolol

(2008) Amy J. Sehnert et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Tackling heart failure in the twenty-first century

(2008) James O. Mudd et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass

(2008) Enrico Petretto et al.   NATURE GENETICS

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics

(2008) Stephen A. Ramsey et al.   PLoS Computational Biology

Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

(2008) Christine T. Ferrara et al.   PLoS Genetics