Virus-like particles as universal influenza vaccines

Influenza M1 VLPs containing neuraminidase induce heterosubtypic cross-protection

(2012) Fu-Shi Quan et al.   VIROLOGY

Virus‑like particles as a vaccine delivery system: Myths and facts

(2011) Polly Roy et al.   Human vaccines & immunotherapeutics

Comment on "Flagellin as an Adjuvant: Cellular Mechanisms and Potential"

(2011) J. P. Pandey   JOURNAL OF IMMUNOLOGY

How Do Aminoadamantanes Block the Influenza M2 Channel, and How Does Resistance Develop?

(2011) Hadas Leonov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influenza Virus-Like Particles Containing M2 Induce Broadly Cross Protective Immunity

(2011) Jae-Min Song et al.   PLoS One

Potent Neutralization of Influenza A Virus by a Single-Domain Antibody Blocking M2 Ion Channel Protein

(2011) Guowei Wei et al.   PLoS One

Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses

(2011) M. R. Sandbulte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fabrication of influenza virus-like particles using M2 fusion proteins for imaging single viruses and designing vaccines

(2011) Hung-Ju Wei et al.   VACCINE

Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)

(2011) David N. Taylor et al.   VACCINE

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

Immunogenicity of low-pH treated whole viral influenza vaccine

(2011) Fu-Shi Quan et al.   VIROLOGY

Enhanced Mucosal Immune Responses to HIV Virus-Like Particles Containing a Membrane-Anchored Adjuvant

(2011) E. V. Vassilieva et al.   mBio

Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus

(2010) Anwar M. Hashem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flagellin as an Adjuvant: Cellular Mechanisms and Potential

(2010) S. B. Mizel et al.   JOURNAL OF IMMUNOLOGY

Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

(2010) K. El Bakkouri et al.   JOURNAL OF IMMUNOLOGY

Intranasal Immunization with Influenza VLPs Incorporating Membrane-Anchored Flagellin Induces Strong Heterosubtypic Protection

(2010) Bao-Zhong Wang et al.   PLoS One

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes

(2010) T. T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

(2010) G. Bommakanti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination inducing broad and improved cross protection against multiple subtypes of influenza A virus

(2010) J.-M. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV

(2010) Rongxin Zhang et al.   VACCINE

In vitro stimulation of human influenza-specific CD8+ T cells by dendritic cells pulsed with an influenza virus-like particle (VLP) vaccine

(2010) Haifeng Song et al.   VACCINE

Phase 1 clinical trials of the safety and immunogenicity of adjuvanted plasmid DNA vaccines encoding influenza A virus H5 hemagglutinin

(2010) Larry R. Smith et al.   VACCINE

Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles

(2010) Jae-Min Song et al.   VIROLOGY

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Broadly Protective Monoclonal Antibodies against H3 Influenza Viruses following Sequential Immunization with Different Hemagglutinins

(2010) Taia T. Wang et al.   PLoS Pathogens

Increasing M2 epitope density enhances systemic and mucosal immune responses to influenza A virus

(2009) Shaobo Pei et al.   BIOTECHNOLOGY LETTERS

Host responses from innate to adaptive immunity after vaccination: Molecular and cellular events

(2009) Sang-Moo Kang et al.   MOLECULES AND CELLS

A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide

(2009) Changgui Li et al.   Nature Protocols

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles

(2009) Sang-Moo Kang et al.   PLoS One

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Comparative immunogenicity evaluations of influenza A virus M2 peptide as recombinant virus like particle or conjugate vaccines in mice and monkeys

(2009) Tong-Ming Fu et al.   VACCINE

Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses

(2009) Graeme E. Price et al.   VACCINE

Influenza virus morphogenesis and budding

(2009) Debi P. Nayak et al.   VIRUS RESEARCH

An Influenza A Vaccine Based on Tetrameric Ectodomain of Matrix Protein 2

(2008) Marina De Filette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmid DNA–Based Vaccines Protect Mice and Ferrets against Lethal Challenge with A/Vietnam/1203/04 (H5N1) Influenza Virus

(2008) Peggy A. Lalor et al.   JOURNAL OF INFECTIOUS DISEASES

Monoclonal Antibodies against the Fusion Peptide of Hemagglutinin Protect Mice from Lethal Influenza A Virus H5N1 Infection

(2008) N. Prabhu et al.   JOURNAL OF VIROLOGY

Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

(2008) B.-Z. Wang et al.   JOURNAL OF VIROLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle

(2008) Rick A. Bright et al.   PLoS One

Heterosubtypic protection conferred by combined vaccination with M2e peptide and split influenza vaccine

(2008) Fan Wu et al.   VACCINE

Protection of chickens against H5N1 highly pathogenic avian influenza virus infection by live vaccination with infectious laryngotracheitis virus recombinants expressing H5 hemagglutinin and N1 neuraminidase

(2008) Sophia P. Pavlova et al.   VACCINE

Efficient induction of mucosal and systemic immune responses by virus-like particles administered intranasally: implications for vaccine design

(2007) Juliana Bessa et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

(2007) James W. Huleatt et al.   VACCINE