Virus-like particles produced in plants as potential vaccines

Plant-produced recombinant influenza vaccine based on virus-like HBc particles carrying an extracellular domain of M2 protein

(2012) N. V. Ravin et al.   BIOCHEMISTRY-MOSCOW

Gag-Specific Cellular Immunity DeterminesIn VitroViral Inhibition andIn VivoVirologic Control following Simian Immunodeficiency Virus Challenges of Vaccinated Rhesus Monkeys

(2012) Kathryn E. Stephenson et al.   JOURNAL OF VIROLOGY

Comparative analysis of recombinant Human Papillomavirus 8 L1 production in plants by a variety of expression systems and purification methods

(2012) Slavica Matić et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant expression, lyophilisation and storage of HBV medium and large surface antigens for a prototype oral vaccine formulation

(2012) Tomasz Pniewski et al.   PLANT CELL REPORTS

In planta production of a candidate vaccine against bovine papillomavirus type 1

(2012) Andrew J. Love et al.   PLANTA

Identification and Differentiation of the Twenty Six Bluetongue Virus Serotypes by RT–PCR Amplification of the Serotype-Specific Genome Segment 2

(2012) Narender S. Maan et al.   PLoS One

Production of foreign proteins using plastid transformation

(2011) Nunzia Scotti et al.   BIOTECHNOLOGY ADVANCES

Efficacy and Safety of Prophylactic Vaccines against Cervical HPV Infection and Diseases among Women: A Systematic Review & Meta-Analysis

(2011) Beibei Lu et al.   BMC INFECTIOUS DISEASES

Developments in virus-like particle-based vaccines for infectious diseases and cancer

(2011) Luigi Buonaguro et al.   Expert Review of Vaccines

A plant-based system for rapid production of influenza vaccine antigens

(2011) Yoko Shoji et al.   Influenza and Other Respiratory Viruses

Delivery of chimeric hepatitis B core particles into liver cells

(2011) K.W. Lee et al.   JOURNAL OF APPLIED MICROBIOLOGY

VP8* antigen produced in tobacco transplastomic plants confers protection against bovine rotavirus infection in a suckling mouse model

(2011) E.M. Lentz et al.   JOURNAL OF BIOTECHNOLOGY

Molecular and process design for rotavirus-like particle production in Saccharomyces cerevisiae

(2011) William A Rodríguez-Limas et al.   Microbial Cell Factories

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

(2011) Huafang Lai et al.   PLANT BIOTECHNOLOGY JOURNAL

Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations

(2011) Huafang Lai et al.   PLANT CELL REPORTS

Characterization of Protection Afforded by a Bivalent Virus-Like Particle Vaccine against Bluetongue Virus Serotypes 1 and 4 in Sheep

(2011) Ana Cristina Pérez de Diego et al.   PLoS One

A bi-functional hepatitis B virus core antigen (HBcAg) chimera activates HBcAg-specific T cells and preS1-specific antibodies

(2011) Imran Riaz Malik et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Cowpea mosaic Virus: The Plant Virus–Based Biotechnology Workhorse

(2010) Frank Sainsbury et al.   Annual Review of Phytopathology

Formation of virus-like particles from O-type foot-and-mouth disease virus in insect cells using codon-optimized synthetic genes

(2010) Yimei Cao et al.   BIOTECHNOLOGY LETTERS

Plant-based anti-HIV-1 strategies: vaccine molecules and antiviral approaches

(2010) Nunzia Scotti et al.   Expert Review of Vaccines

Human papillomavirus vaccines in plants

(2010) Colomba Giorgi et al.   Expert Review of Vaccines

Norwalk virus-like particles as vaccines

(2010) Melissa Herbst-Kralovetz et al.   Expert Review of Vaccines

Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation

(2010) Tomasz Pniewski et al.   JOURNAL OF APPLIED GENETICS

Rotavirus Strain Types Circulating in Africa: Review of Studies Published during 1997–2006

(2010) Stacy Todd et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization and Diagnostic Potential of Foreign Epitope-Presenting Ty1 Virus-Like Particles Expressed in Escherichia coli and Pichia pastoris

(2010) Kerstin Uhde-Holzem et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Progress towards development of an HIV vaccine: report of the AIDS Vaccine 2009 Conference

(2010) Anna Laura Ross et al.   LANCET INFECTIOUS DISEASES

Production of Human Rotavirus and Salmonella Antigens in Plants and Elicitation of fljB-Specific Humoral Responses in Mice

(2010) Louis-Philippe Bergeron-Sandoval et al.   MOLECULAR BIOTECHNOLOGY

Plant-made vaccines for humans and animals

(2010) Edward P. Rybicki   PLANT BIOTECHNOLOGY JOURNAL

Development ofTobacco necrosis virus Aas a vector for efficient and stable expression of FMDV VP1 peptides

(2010) Yongliang Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Immunogenicity and virus-like particle formation of rotavirus capsid proteins produced in transgenic plants

(2010) YanMei Yang et al.   Science China-Life Sciences

Transplastomic expression of a modified human papillomavirus L1 protein leading to the assembly of capsomeres in tobacco: a step towards cost-effective second-generation vaccines

(2010) M. Tahir Waheed et al.   TRANSGENIC RESEARCH

Overview of expression of hepatitis B surface antigen in transgenic plants

(2010) Zheng-jun Guan et al.   VACCINE

HIV vaccines: lessons learned and the way forward

(2010) Jerome H Kim et al.   Current Opinion in HIV and AIDS

A DNA replicon system for rapid high-level production of virus-like particles in plants

(2009) Zhong Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Virus-like particle vaccines and adjuvants: the HPV paradigm

(2009) Franco Maria Buonaguro et al.   Expert Review of Vaccines

Chimeric L1-L2 Virus-Like Particles as Potential Broad-Spectrum Human Papillomavirus Vaccines

(2009) C. Schellenbacher et al.   JOURNAL OF VIROLOGY

The Ever-Changing Landscape of Rotavirus Serotypes

(2009) Miguel OʼRyan   PEDIATRIC INFECTIOUS DISEASE JOURNAL

High level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector

(2009) Guy L. Regnard et al.   PLANT BIOTECHNOLOGY JOURNAL

High-level expression of the HIV-1 Pr55gag polyprotein in transgenic tobacco chloroplasts

(2009) Nunzia Scotti et al.   PLANTA

Plant-based strategies aimed at expressing HIV antigens and neutralizing antibodies at high levels. Nef as a case study

(2009) Carla Marusic et al.   TRANSGENIC RESEARCH

A prime–boost immunisation regimen using recombinant BCG and Pr55gag virus-like particle vaccines based on HIV type 1 subtype C successfully elicits Gag-specific responses in baboons

(2009) Gerald K. Chege et al.   VACCINE

Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells

(2009) Anna Kostrzak et al.   VACCINE

Validation of a novel approach for the rapid production of immunogenic virus-like particles for bluetongue virus

(2009) M. Stewart et al.   VACCINE

Zoonotic aspects of rotaviruses

(2009) V. Martella et al.   VETERINARY MICROBIOLOGY

Expression of HIV-1 antigens in plants as potential subunit vaccines

(2008) Ann Meyers et al.   BMC BIOTECHNOLOGY

Plant-produced vaccines: promise and reality

(2008) Edward P. Rybicki   DRUG DISCOVERY TODAY

HIV-1 subtype C Pr55gag virus-like particle vaccine efficiently boosts baboons primed with a matched DNA vaccine

(2008) G. K. Chege et al.   JOURNAL OF GENERAL VIROLOGY

Rotavirus Architecture at Subnanometer Resolution

(2008) Z. Li et al.   JOURNAL OF VIROLOGY

Human Papillomavirus Vaccination — Reasons for Caution

(2008) Charlotte J. Haug   NEW ENGLAND JOURNAL OF MEDICINE

Human papillomavirus L1 protein expressed in tobacco chloroplasts self-assembles into virus-like particles that are highly immunogenic

(2008) Alicia Fernández-San Millán et al.   PLANT BIOTECHNOLOGY JOURNAL

High-yield rapid production of hepatitis B surface antigen in plant leaf by a viral expression system

(2008) Zhong Huang et al.   PLANT BIOTECHNOLOGY JOURNAL

Transient and stable expression of hepatitis B surface antigen in tomato (Lycopersicon esculentum L.)

(2008) L. Srinivas et al.   Plant Biotechnology Reports

Extremely High-Level and Rapid Transient Protein Production in Plants without the Use of Viral Replication

(2008) F. Sainsbury et al.   PLANT PHYSIOLOGY

Epidemiology and Natural History of Human Papillomavirus Infections and Type-Specific Implications in Cervical Neoplasia

(2008) F. Xavier Bosch et al.   VACCINE

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

(2008) Luca Santi et al.   VACCINE

Bovine papillomaviruses, papillomas and cancer in cattle

(2008) Giuseppe Borzacchiello et al.   VETERINARY RESEARCH

Vaccines against bluetongue in Europe

(2007) Giovanni Savini et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Association of bovine papillomavirus type-2 and urinary bladder tumours in cattle from Romania

(2007) L.G.F. Balcos et al.   RESEARCH IN VETERINARY SCIENCE

Foliar extracts from transgenic tomato plants expressing the structural polyprotein, P1-2A, and protease, 3C, from foot-and-mouth disease virus elicit a protective response in guinea pigs

(2007) Li Pan et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY