Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer

Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

(2012) Katie Twigger et al.   BMC CANCER

Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies

(2012) E. M. Karapanagiotou et al.   CLINICAL CANCER RESEARCH

Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin–paclitaxel doublet chemotherapy

(2012) V Roulstone et al.   GENE THERAPY

REO-001: A phase I trial of percutaneous intralesional administration of reovirus type 3 dearing (Reolysin®) in patients with advanced solid tumors

(2012) Don G. Morris et al.   INVESTIGATIONAL NEW DRUGS

Reovirus: A Targeted Therapeutic--Progress And Potential

(2012) R. Maitra et al.   MOLECULAR CANCER RESEARCH

Stress management at the ER: Regulators of ER stress-induced apoptosis

(2012) Adrienne M. Gorman et al.   PHARMACOLOGY & THERAPEUTICS

RAIDDing ER Stress for Oncolytic Viral Therapy

(2011) David J. McConkey   CANCER CELL

Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death

(2011) Douglas J. Mahoney et al.   CANCER CELL

K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis

(2011) Yumin Hu et al.   CELL RESEARCH

Reovirus therapy stimulates endoplasmic reticular stress, NOXA induction and augments bortezomib-mediated apoptosis in multiple myeloma

(2011) K R Kelly et al.   ONCOGENE

Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-Mediated Potentiation of Bortezomib-Induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells

(2010) R. Rao et al.   CLINICAL CANCER RESEARCH

A Phase I Study of the Combination of Intravenous Reovirus Type 3 Dearing and Gemcitabine in Patients with Advanced Cancer

(2010) M. P. Lolkema et al.   CLINICAL CANCER RESEARCH

REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer

(2010) C. Comins et al.   CLINICAL CANCER RESEARCH

Clinical trials with oncolytic reovirus: Moving beyond phase I into combinations with standard therapeutics

(2010) K.J. Harrington et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells

(2010) Shujie Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Synergistic Effects of Oncolytic Reovirus and Cisplatin Chemotherapy in Murine Malignant Melanoma

(2009) H. S. Pandha et al.   CLINICAL CANCER RESEARCH

Targeting the endoplasmic reticulum-stress response as an anticancer strategy

(2009) Sandra J.M. Healy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reovirus-based therapy for cancer

(2009) Kevin Kelly et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cells

(2009) Shizuko Sei et al.   Molecular Cancer

A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer

(2008) L. Vidal et al.   CLINICAL CANCER RESEARCH

Cyclophosphamide Facilitates Antitumor Efficacy against Subcutaneous Tumors following Intravenous Delivery of Reovirus

(2008) J. Qiao et al.   CLINICAL CANCER RESEARCH

Enhanced In vitro and In vivo Cytotoxicity of Combined Reovirus and Radiotherapy

(2008) K. Twigger et al.   CLINICAL CANCER RESEARCH

Involvement of endoplasmic reticulum in paclitaxel‐induced apoptosis

(2008) Pei‐Chun Liao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing

(2008) A. Pataer et al.   MOLECULAR CANCER THERAPEUTICS

A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas

(2008) Peter Forsyth et al.   MOLECULAR THERAPY