Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells

Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor–kappa B activity

(2013) Tara C.K. Krosch et al.   AMERICAN JOURNAL OF SURGERY

Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim

(2013) Tom Verfaillie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Minnelide reduces tumor burden in preclinical models of osteosarcoma

(2013) Sulagna Banerjee et al.   CANCER LETTERS

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Identification of a Novel Endoplasmic Reticulum Stress Response Element Regulated by XBP1

(2013) Michael Misiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated byO-GlcNAc Modification of Transcription Factor Sp1

(2013) Sulagna Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triptolide Induces the Expression of miR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation

(2013) T. N. MacKenzie et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells

(2012) Chong Zhao et al.   Autophagy

Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells

(2012) Hongdan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

(2012) R. Chugh et al.   Science Translational Medicine

Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity

(2012) Britta Hardy et al.   CELLULAR ONCOLOGY

Overexpression of GRP78 Is Associated With Malignant Transformation in Epithelial Ovarian Tumors

(2012) Lee-Wen Huang et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

The Expression of the Endoplasmic Reticulum Stress Sensor BiP/GRP78 Predicts Response to Chemotherapy and Determines the Efficacy of Proteasome Inhibitors in Diffuse Large B-Cell Lymphoma

(2011) Ana Mozos et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms of ER Stress-Induced Apoptosis in Atherosclerosis

(2011) Christopher M. Scull et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel Mechanism of Anti-apoptotic Function of 78-kDa Glucose-regulated Protein (GRP78)

(2011) Hui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Global Patterns of Cancer Incidence and Mortality Rates and Trends

(2010) A. Jemal et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

(2010) Feras Y. Al-Rawashdeh et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways

(2010) Nameeta Mujumdar et al.   GASTROENTEROLOGY

Triptolide and TRAIL Combination Enhances Apoptosis in Cholangiocarcinoma

(2010) Kimberly A. Clawson et al.   JOURNAL OF SURGICAL RESEARCH

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy

(2009) Soledad Matus et al.   Autophagy

Glucose-regulated protein 78 expression in urothelial carcinoma of the upper urinary tract

(2009) Kenji Uematsu et al.   BJU INTERNATIONAL

Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms

(2009) Vikas Dudeja et al.   GASTROENTEROLOGY

Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3β androstene 17α diol neuro-steroid on malignant glioma cells

(2009) Martin R. Graf et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The UPR as a survival factor of cancer cells: More than folding proteins?

(2009) Claudio Hetz   LEUKEMIA RESEARCH

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo

(2009) Mara B. Antonoff et al.   SURGERY

The PERK/eIF2α signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells

(2008) Wai-Lung Lai et al.   EXPERIMENTAL CELL RESEARCH