The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

Targeting transcription factor NFκB: comparative analysis of proteasome and IKK inhibitors

(2010) Alexander V. Gasparian et al.   CELL CYCLE

A Randomized Phase 2 Study of Erlotinib Alone and in Combination with Bortezomib in Previously Treated Advanced Non-small Cell Lung Cancer

(2010) Thomas J. Lynch et al.   Journal of Thoracic Oncology

NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy

(2009) Han-Ming Shen et al.   APOPTOSIS

Biologic sequelae of I B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

(2009) T. Hideshima et al.   BLOOD

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

(2009) Denise A. Chan et al.   CANCER CELL

Suppression of NF- B activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells

(2009) A. Kim et al.   CARCINOGENESIS

PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis

(2009) P Wang et al.   CELL DEATH AND DIFFERENTIATION

Constitutive NF- B Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth

(2009) K. Sakamoto et al.   CLINICAL CANCER RESEARCH

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

IKK -mediated nuclear factor- B activation attenuates smac mimetic-induced apoptosis in cancer cells

(2009) L. Bai et al.   MOLECULAR CANCER THERAPEUTICS

Updates on p53: modulation of p53 degradation as a therapeutic approach

(2008) A Dey et al.   BRITISH JOURNAL OF CANCER

Multi-targeted prevention and therapy of cancer by proanthocyanidins

(2008) Vijayalakshmi Nandakumar et al.   CANCER LETTERS

Stromal cell-derived factor-1α (SDF-1α/CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2–NF-κB/interleukin-6 pathway

(2008) Chia-Yu Chu et al.   CARCINOGENESIS

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells

(2008) C. M. Sloss et al.   CLINICAL CANCER RESEARCH

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Nuclear Factor-κB Activation: From Bench to Bedside

(2008) Gautam Sethi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockage of NF-κB by IKKβ- or RelA-siRNA rather than the NF-κB super-suppressor IκBα mutant potentiates adriamycin-induced cytotoxicity in lung cancer cells

(2008) Wenshu Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

Is NF-κB a good target for cancer therapy? Hopes and pitfalls

(2008) Véronique Baud et al.   NATURE REVIEWS DRUG DISCOVERY

NSAIDs Downregulate Bcl-XLand Dissociate BAX and Bcl-XLto Induce Apoptosis in Colon Cancer Cells

(2008) Alexander Bank et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation

(2008) Normand Podechard et al.   TOXICOLOGY LETTERS

NF-kappaB: a potential target for cancer chemoprevention and therapy

(2007) Fazlul et al.   Frontiers in Bioscience-Landmark