The role of mTOR-mediated signals during haemopoiesis and lineage commitment

mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8

(2018) Yang Zhao et al.   BLOOD

An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion

(2018) Christian Baumgartner et al.   Cell Stem Cell

miR-9 upregulation leads to inhibition of erythropoiesis by repressing FoxO3

(2018) Yunyuan Zhang et al.   Scientific Reports

mTOR complexes differentially orchestrates eosinophil development in allergy

(2018) Chen Zhu et al.   Scientific Reports

Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice

(2018) Vladimir R. Babaev et al.   Frontiers in Immunology

Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF–mediated myelopoiesis

(2017) Peer W.F. Karmaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylation

(2017) Chien-An Yao et al.   Oncotarget

A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

(2017) Fei Tang et al.   eLife

Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids

(2016) Lee-Ann Van de Velde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR has distinct functions in generating versus sustaining humoral immunity

(2016) Derek D. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development

(2016) Hong-Xia Wang et al.   JOURNAL OF IMMUNOLOGY

Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism

(2016) Terri N. Iwata et al.   JOURNAL OF IMMUNOLOGY

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

(2016) Mulki Angela et al.   Nature Communications

Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice

(2016) Colin Selman et al.   Oncotarget

AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin

(2016) Mei Gao et al.   Oncotarget

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

(2016) Lianjun Zhang et al.   Cell Reports

Signalling to eIF4E in cancer

(2015) N. Siddiqui et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Autophagy as a Regulatory Component of Erythropoiesis

(2015) Jieying Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1

(2015) Zhipeng Zou et al.   JOURNAL OF CELL BIOLOGY

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

The S6K protein family in health and disease

(2015) Mariana R. Tavares et al.   LIFE SCIENCES

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

(2015) Jacky Chung et al.   Science Signaling

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

(2015) Jacky Chung et al.   Science Signaling

FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis

(2014) Xin Zhang et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mammalian Target of Rapamycin Complex 2 Regulates Invariant NKT Cell Development and Function Independent of Promyelocytic Leukemia Zinc-Finger

(2014) Nicolas Prevot et al.   JOURNAL OF IMMUNOLOGY

PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils

(2014) Lunhua Liu et al.   MOLECULAR BIOLOGY OF THE CELL

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

(2014) William J. Faller et al.   NATURE

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

(2014) Emily B Heikamp et al.   NATURE IMMUNOLOGY

Myeloid-Specific Rictor Deletion Induces M1 Macrophage Polarization and Potentiates In Vivo Pro-Inflammatory Response to Lipopolysaccharide

(2014) William T. Festuccia et al.   PLoS One

Rictor Is Required for Early B Cell Development in Bone Marrow

(2014) Yingchi Zhang et al.   PLoS One

Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells

(2014) T. Hoshii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical role for mTORC1 in erythropoiesis and anemia

(2014) Zachary A Knight et al.   eLife

Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy

(2013) Asako Itakura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Requirement for Rictor in homeostasis and function of mature B lymphoid cells

(2013) K. Lee et al.   BLOOD

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis

(2013) F. Guo et al.   HAEMATOLOGICA

B-cell biology and development

(2013) Kathrin Pieper et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence

(2013) Yi Luo et al.   TRANSPLANTATION

The TSC-mTOR pathway regulates macrophage polarization

(2013) Vanessa Byles et al.   Nature Communications

The Paradox of Akt-mTOR Interactions

(2013) Lakshmipathi Vadlakonda et al.   Frontiers in Oncology

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  

(2012) A. M. McInturff et al.   BLOOD

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression

(2012) Jeffrey A. Magee et al.   Cell Stem Cell

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

(2012) Demetrios Kalaitzidis et al.   Cell Stem Cell

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

mTORC1 is essential for leukemia propagation but not stem cell self-renewal

(2012) Takayuki Hoshii et al.   JOURNAL OF CLINICAL INVESTIGATION

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

(2012) Keunwook Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Critical Role for Rictor in T Lymphopoiesis

(2012) F. Tang et al.   JOURNAL OF IMMUNOLOGY

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways

(2012) Jian Huang et al.   NATURE MEDICINE

Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells

(2011) Sandrine Benhamron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

(2011) Jonathan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

(2011) E. A. Goncharova et al.   MOLECULAR AND CELLULAR BIOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells

(2011) C K M Ip et al.   ONCOGENE

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

(2010) S. Zhang et al.   BLOOD

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells

(2010) Adam S. Lazorchak et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

Pivotal role for glycogen synthase kinase–3 in hematopoietic stem cell homeostasis in mice

(2009) Jian Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Rictor is a novel target of p70 S6 kinase-1

(2009) C Treins et al.   ONCOGENE

Protein kinase Cα: disease regulator and therapeutic target

(2009) Olga Konopatskaya et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

(2008) B. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA