Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia

(2012) Catherine M. Sawai et al.   CANCER CELL

Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression

(2012) Jeffrey A. Magee et al.   Cell Stem Cell

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

(2012) Demetrios Kalaitzidis et al.   Cell Stem Cell

mTORC1 is essential for leukemia propagation but not stem cell self-renewal

(2012) Takayuki Hoshii et al.   JOURNAL OF CLINICAL INVESTIGATION

Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression

(2012) Sarah E. Powers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

(2012) Keunwook Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Targeting mTOR with rapamycin: One dose does not fit all

(2011) David A. Foster et al.   CELL CYCLE

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies

(2009) David T. Teachey et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Requirement for Cyclin-Dependent Kinase 6 in Thymocyte Development and Tumorigenesis

(2009) M. G. Hu et al.   CANCER RESEARCH

Oncogenic Kras Initiates Leukemia in Hematopoietic Stem Cells

(2009) Amit J Sabnis et al.   PLOS BIOLOGY

Exploiting the mammalian target of rapamycin pathway in hematologic malignancies

(2008) Jessica K Altman et al.   CURRENT OPINION IN HEMATOLOGY

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE