FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

(2014) Pauline Rimmelé et al.   Stem Cell Reports

Stem Cells, Redox Signaling, and Stem Cell Aging

(2013) Raymond Liang et al.   ANTIOXIDANTS & REDOX SIGNALING

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells

(2013) Hyeonju Yeo et al.   EMBO JOURNAL

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

(2013) S. S. Franco et al.   HAEMATOLOGICA

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression

(2013) C Marty et al.   LEUKEMIA

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

(2013) Pedro Ramos et al.   NATURE MEDICINE

EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress

(2012) S. A. Peslak et al.   BLOOD

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

The role of ineffective erythropoiesis in non-transfusion-dependent thalassemia

(2012) Stefano Rivella   BLOOD REVIEWS

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

(2012) Marina Bayeva et al.   Cell Metabolism

Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors

(2012) Renaud Geslain et al.   CYTOKINE

Hydroxyurea responsiveness in  -thalassemic patients is determined by the stress response adaptation of erythroid progenitors and their differentiation propensity

(2012) F. Pourfarzad et al.   HAEMATOLOGICA

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

(2012) Kristan E. van der Vos et al.   NATURE CELL BIOLOGY

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Regulation and Function of FoxO Transcription Factors in Normal and Cancer Stem Cells: What Have We Learned?

(2011) Xin Zhang et al.   CURRENT DRUG TARGETS

Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

(2011) Sei Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

(2011) Xin Zhang et al.   NATURE CELL BIOLOGY

mTOR inhibition and erythropoiesis: microcytosis or anaemia?

(2011) F. Diekmann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

(2011) Jessica J. Howell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Integrating Opposing Signals Toward Forkhead Box O

(2010) Maaike C.W. van den Berg et al.   ANTIOXIDANTS & REDOX SIGNALING

During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool

(2010) A. Dev et al.   BLOOD

Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus

(2010) S. J. England et al.   BLOOD

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

(2010) Chia-Chen Chen et al.   DEVELOPMENTAL CELL

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

miR-451 protects against erythroid oxidant stress by repressing 14-3-3 

(2010) D. Yu et al.   GENES & DEVELOPMENT

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ineffective erythropoiesis and thalassemias

(2009) Stefano Rivella   CURRENT OPINION IN HEMATOLOGY

Posttransplant anemia: the role of sirolimus

(2009) Steven Fishbane et al.   KIDNEY INTERNATIONAL

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis

(2009) K. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation

(2008) G. Grech et al.   BLOOD

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in  -thalassemia

(2008) I. V. Libani et al.   BLOOD

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

(2008) Safak Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY