A critical role for mTORC1 in erythropoiesis and anemia

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis

(2013) F. Guo et al.   HAEMATOLOGICA

Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation Stabilizes ISCU Protein

(2013) Ping La et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal-Specific Iron Deficiency Dysregulates Mammalian Target of Rapamycin Signaling during Hippocampal Development in Nonanemic Genetic Mouse Models

(2013) Stephanie J. B. Fretham et al.   JOURNAL OF NUTRITION

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia

(2012) P. Jaako et al.   BLOOD

L-leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway

(2012) E. M. Payne et al.   BLOOD

Abstract 5588: A phase I, open label, dose escalation study of an oral mammalian target of rapamycin inhibitor INK128 administered once daily in patients with advanced malignancies

(2012) Jeffrey R. Infante et al.   CANCER RESEARCH

Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

(2012) Zachary A. Knight et al.   CELL

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

(2012) Marina Bayeva et al.   Cell Metabolism

Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression

(2012) Jeffrey A. Magee et al.   Cell Stem Cell

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

(2012) Demetrios Kalaitzidis et al.   Cell Stem Cell

mTORC1 is essential for leukemia propagation but not stem cell self-renewal

(2012) Takayuki Hoshii et al.   JOURNAL OF CLINICAL INVESTIGATION

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Striatal Cholinergic Interneurons Display Activity-Related Phosphorylation of Ribosomal Protein S6

(2012) Jesus Bertran-Gonzalez et al.   PLoS One

mTORC1 signaling governs hematopoietic stem cell quiescence

(2011) Boyi Gan et al.   CELL CYCLE

p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis

(2011) Simon M Schultze et al.   CELL RESEARCH

Stress erythropoiesis: new signals and new stress progenitor cells

(2011) Robert F Paulson et al.   CURRENT OPINION IN HEMATOLOGY

mTOR inhibition and erythropoiesis: microcytosis or anaemia?

(2011) F. Diekmann et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Haloperidol Regulates the State of Phosphorylation of Ribosomal Protein S6 via Activation of PKA and Phosphorylation of DARPP-32

(2011) Emmanuel Valjent et al.   NEUROPSYCHOPHARMACOLOGY

Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy

(2010) Andrew Y. Choo et al.   CELL CYCLE

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

(2010) T Gan et al.   LEUKEMIA

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1

(2009) Junko H. Ohyashiki et al.   CANCER SCIENCE

Complex Regulation of Mammalian Target of Rapamycin Complex 1 in the Basomedial Hypothalamus by Leptin and Nutritional Status

(2009) Eneida C. Villanueva et al.   ENDOCRINOLOGY

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Iron deficiency down-regulates the Akt/TSC1-TSC2/mammalian Target of Rapamycin signaling pathway in rats and in COS-1 cells

(2009) Moussa Ndong et al.   NUTRITION RESEARCH

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

(2008) B. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA