Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

(2012) Angelika Horn et al.   ANNALS OF THE RHEUMATIC DISEASES

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease

(2012) P. Zerr et al.   BLOOD

Innovative antifibrotic therapies in systemic sclerosis

(2012) Christian Beyer et al.   CURRENT OPINION IN RHEUMATOLOGY

Three decades of Wnts: a personal perspective on how a scientific field developed

(2012) Roel Nusse et al.   EMBO JOURNAL

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Wnt Signaling

(2012) R. Nusse   Cold Spring Harbor Perspectives in Biology

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

(2011) C. Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of glycogen synthase kinase 3  induces dermal fibrosis by activation of the canonical Wnt pathway

(2011) C. Bergmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

(2011) Jun Wei et al.   ARTHRITIS AND RHEUMATISM

Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues

(2011) Benjamin D. Simons et al.   CELL

γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

(2011) Bruno P. Imbimbo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Notch in the kidney: development and disease

(2011) Yasemin Sirin et al.   JOURNAL OF PATHOLOGY

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

Hedgehog morphogen: from secretion to reception

(2011) Armel Gallet   TRENDS IN CELL BIOLOGY

Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model

(2010) Niloufar Kavian et al.   ARTHRITIS AND RHEUMATISM

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

(2010) Zainab Jagani et al.   NATURE MEDICINE

SUMOylation by Pias1 Regulates the Activity of the Hedgehog Dependent Gli Transcription Factors

(2010) Barny Cox et al.   PLoS One

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective activation mechanisms of Wnt signaling pathways

(2009) Akira Kikuchi et al.   TRENDS IN CELL BIOLOGY

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction

(2008) Koichi Kobayashi et al.   NATURE CELL BIOLOGY

Increased Expression of Wnt2 and SFRP4 in Tsk Mouse Skin: Role of Wnt Signaling in Altered Dermal Fibrillin Deposition and Systemic Sclerosis

(2007) Julie Bayle et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY