Toward Understanding Induction of Oxidative Stress and Apoptosis by Proteasome Inhibitors

Regulation of the Proteasome: Evaluating the Lung Proteasome as a New Therapeutic Target

(2014) Silke Meiners et al.   ANTIOXIDANTS & REDOX SIGNALING

Harnessing Proteasome Dynamics and Allostery in Drug Design

(2014) Maria Gaczynska et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting the Ubiquitin-Proteasome System in Heart Disease: The Basis for New Therapeutic Strategies

(2014) Oliver Drews et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting the Ubiquitin-Proteasome System in Atherosclerosis: Status Quo, Challenges, and Perspectives

(2014) Nicola Wilck et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy

(2014) Yongchao Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

The Ubiquitin-Proteasome System in Neurodegeneration

(2014) Chris McKinnon et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthesis and Pharmacology of Proteasome Inhibitors

(2013) Andreas Rentsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

(2013) B. E. Hast et al.   CANCER RESEARCH

Transmembrane Protein 214 (TMEM214) Mediates Endoplasmic Reticulum Stress-induced Caspase 4 Enzyme Activation and Apoptosis

(2013) Chao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

(2013) Paul P. Geurink et al.   JOURNAL OF MEDICINAL CHEMISTRY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS

(2013) Nan Li et al.   Nature Protocols

BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways

(2013) F Rapino et al.   ONCOGENE

Functions of the 19S complex in proteasomal degradation

(2013) Chang-Wei Liu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Redox Control of 20S Proteasome Gating

(2012) Gustavo M. Silva et al.   ANTIOXIDANTS & REDOX SIGNALING

The proteasome: molecular machinery and pathophysiological roles

(2012) Keiji Tanaka et al.   BIOLOGICAL CHEMISTRY

Covalent and non-covalent reversible proteasome inhibition

(2012) Philipp Beck et al.   BIOLOGICAL CHEMISTRY

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

DangER: protein ovERload. Targeting protein degradation to treat myeloma

(2012) L. I. Aronson et al.   HAEMATOLOGICA

Development of proteasome inhibitors as research tools and cancer drugs

(2012) Alfred L. Goldberg   JOURNAL OF CELL BIOLOGY

Molecular Mechanisms of Acquired Proteasome Inhibitor Resistance

(2012) Andrew J. Kale et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptido Sulfonyl Fluorides as New Powerful Proteasome Inhibitors

(2012) Arwin J. Brouwer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteasome inhibitor-based therapy for antibody-mediated rejection

(2012) R. Carlin Walsh et al.   KIDNEY INTERNATIONAL

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hydroxyureas as Noncovalent Proteasome Inhibitors

(2011) Nerea Gallastegui et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A bright approach to the immunoproteasome: Development of LMP2/β1i-specific imaging probes

(2011) Kimberly Cornish Carmony et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition

(2011) J. Hu et al.   BLOOD

High Basal Nuclear Levels of Nrf2 in Acute Myeloid Leukemia Reduces Sensitivity to Proteasome Inhibitors

(2011) S. A. Rushworth et al.   CANCER RESEARCH

Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

(2011) Robert Karisch et al.   CELL

Order of the Proteasomal ATPases and Eukaryotic Proteasome Assembly

(2011) Robert J. Tomko et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

(2011) Claudia P. Miller et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib

(2011) Anne C. Mirabella et al.   CHEMISTRY & BIOLOGY

Molecular Pathways: Targeting Proteasomal Protein Degradation in Cancer

(2011) S. M. Molineaux   CLINICAL CANCER RESEARCH

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events

(2011) S. Arastu-Kapur et al.   CLINICAL CANCER RESEARCH

Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials

(2011) B. C. Potts et al.   CURRENT CANCER DRUG TARGETS

Proteasome subtypes and the processing of tumor antigens: increasing antigenic diversity

(2011) Nathalie Vigneron et al.   CURRENT OPINION IN IMMUNOLOGY

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma

(2011) Apollina Goel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bortezomib stabilizes NOXA and triggers ROS-associated apoptosis in medulloblastoma

(2011) Sachiko Ohshima-Hosoyama et al.   JOURNAL OF NEURO-ONCOLOGY

Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress–Induced Apoptosis in SH-SY5Y Cells

(2011) Akiko Yamamuro et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Proteasome Activators

(2011) Beth M. Stadtmueller et al.   MOLECULAR CELL

Synthesis and SAR Study of Novel Peptide Aldehydes as Inhibitors of 20S Proteasome

(2011) Yuheng Ma et al.   MOLECULES

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones

(2011) Wouter A. van der Linden et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

(2011) M. H. Smith et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

BAG3: a multifaceted protein that regulates major cell pathways

(2011) A Rosati et al.   Cell Death & Disease

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S β5-subunit

(2010) Christopher Blackburn et al.   BIOCHEMICAL JOURNAL

PR-924, a selective inhibitor of the immunoproteasome subunit LMP-7, blocks multiple myeloma cell growth both in vitro and in vivo

(2010) Ajita V. Singh et al.   BRITISH JOURNAL OF HAEMATOLOGY

Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer

(2010) E. Kupperman et al.   CANCER RESEARCH

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

(2010) Bogdan I. Florea et al.   CHEMISTRY & BIOLOGY

Nature of Pharmacophore Influences Active Site Specificity of Proteasome Inhibitors

(2010) Michael Screen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites

(2010) Paul P. Geurink et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Proteasomal Degradation Is Transcriptionally Controlled by TCF11 via an ERAD-Dependent Feedback Loop

(2010) Janos Steffen et al.   MOLECULAR CELL

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

A panel of subunit-selective activity-based proteasome probes

(2010) Martijn Verdoes et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Induction of ER Stress in Macrophages of Tuberculosis Granulomas

(2010) Tracie A. Seimon et al.   PLoS One

Quantitative Phosphoproteomics of Proteasome Inhibition in Multiple Myeloma Cells

(2010) Feng Ge et al.   PLoS One

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

(2010) B. Guillaume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

The 26S proteasome: assembly and function of a destructive machine

(2010) Nerea Gallastegui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils

(2009) François Binet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exclusive expression of proteasome subunit  5t in the human thymic cortex

(2009) U. Tomaru et al.   BLOOD

The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition

(2009) G. Bianchi et al.   BLOOD

Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome

(2009) F. Parlati et al.   BLOOD

Selective Inhibitor of Proteasome's Caspase-like Sites Sensitizes Cells to Specific Inhibition of Chymotrypsin-like Sites

(2009) Matthew Britton et al.   CHEMISTRY & BIOLOGY

A Phase 1 Dose Escalation Study of the Safety and Pharmacokinetics of the Novel Proteasome Inhibitor Carfilzomib (PR-171) in Patients with Hematologic Malignancies

(2009) O. A. O'Connor et al.   CLINICAL CANCER RESEARCH

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)

(2009) Han-Jie Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of the ubiquitin–proteasome system in bortezomib-adapted cells

(2009) T Rückrich et al.   LEUKEMIA

Oncogenic transformation confers a selective susceptibility to the combined suppression of the proteasome and autophagy

(2009) W.-X. Ding et al.   MOLECULAR CANCER THERAPEUTICS

Effect of autophagy on multiple myeloma cell viability

(2009) B. Hoang et al.   MOLECULAR CANCER THERAPEUTICS

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Oxidative Stress by Targeted Agents Promotes Cytotoxicity in Hematologic Malignancies

(2008) Joya Chandra   ANTIOXIDANTS & REDOX SIGNALING

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

(2008) Deborah J. Kuhn et al.   BLOOD

Molecular basis of bortezomib resistance: proteasome subunit  5 (PSMB5) gene mutation and overexpression of PSMB5 protein

(2008) R. Oerlemans et al.   BLOOD

Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib

(2008) Silvia Nerini-Molteni et al.   BRITISH JOURNAL OF HAEMATOLOGY

Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade

(2008) R. Z. Orlowski et al.   CLINICAL CANCER RESEARCH

Discovery of a Potent, Selective, and Orally Active Proteasome Inhibitor for the Treatment of Cancer

(2008) Bruce D. Dorsey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contrasting Proteome Biology and Functional Heterogeneity of the 20 S Proteasome Complexes in Mammalian Tissues

(2008) Aldrin V. Gomes et al.   MOLECULAR & CELLULAR PROTEOMICS

Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma

(2008) Jesús F. San Miguel et al.   NEW ENGLAND JOURNAL OF MEDICINE